- Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L
[作者：Huber, A; French, SL; Tekotte, H; Yerlikaya, S; Stahl, M; Perepelkina, MP; Tyers, M; Rougemont, J; Beyer, AL; Loewith, R,期刊：EMBO journal, 页码：3052-3064 , 文章类型： Article，,卷期：2011年30-15]
- TORC1 is a conserved multisubunit kinase complex that regulates many aspects of eukaryotic growth including the biosynthesis of ribosomes. The TOR protein kinase resident in TORC1 is responsive to environmental cues and ...
- Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry
[作者：Deriziotis, P; Andre, R; Smith, DM; Goold, R; Kinghorn, KJ; Kristiansen, M; Nathan, JA; Rosenzweig, R; Krutauz, D; Glickman, MH; Collinge, J; Goldberg, AL; Tabrizi, SJ,期刊：EMBO journal, 页码：3065-3077 , 文章类型： Article，,卷期：2011年30-15]
- Prion diseases are associated with the conversion of cellular prion protein (PrPC) to toxic beta-sheet isoforms (PrPSc), which are reported to inhibit the ubiquitin-proteasome system (UPS). Accordingly, UPS substrates ac...
- The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins
[作者：Dekker, C; Roe, SM; McCormack, EA; Beuron, F; Pearl, LH; Willison, KR,期刊：EMBO journal, 页码：3078-3090 , 文章类型： Article，,卷期：2011年30-15]
- The cytosolic chaperonin CCT is a 1-MDa protein-folding machine essential for eukaryotic life. The CCT interactome shows involvement in folding and assembly of a small range of proteins linked to essential cellular proce...
- The cohesin subunit RAD21L functions in meiotic synapsis and exhibits sexual dimorphism in fertility
[作者：Herran, Y; Gutierrez-Caballero, C; Sanchez-Martin, M; Hernandez, T; Viera, A; Barbero, JL; de Alava, E; de Rooij, DG; Suja, JA; Llano, E; Pendas, AM,期刊：EMBO journal, 页码：3091-3105 , 文章类型： Article，,卷期：2011年30-15]
- The cohesin complex is a ring-shaped proteinaceous structure that entraps the two sister chromatids after replication until the onset of anaphase when the ring is opened by proteolytic cleavage of its alpha-kleisin subun...
- Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells
[作者：Sela, M; Bogin, Y; Beach, D; Oellerich, T; Lehne, J; Smith-Garvin, JE; Okumura, M; Starosvetsky, E; Kosoff, R; Libman, E; Koretzky, G; Kambayashi, T; Urlaub, H; Wienands, J; Chernoff, J; Yablonski, D,期刊：EMBO journal, 页码：3160-3172 , 文章类型： Article，,卷期：2011年30-15]
- Cooperatively assembled signalling complexes, nucleated by adaptor proteins, integrate information from surface receptors to determine cellular outcomes. In T and mast cells, antigen receptor signalling is nucleated by t...
- A novel strategy for evasion of NK cell immunity by tumours expressing core2 O-glycans
[作者：Tsuboi, S; Sutoh, M; Hatakeyama, S; Hiraoka, N; Habuchi, T; Horikawa, Y; Hashimoto, Y; Yoneyama, T; Mori, K; Koie, T; Nakamura, T; Saitoh, H; Yamaya, K; Funyu, T; Fukuda, M; Ohyama, C,期刊：EMBO journal, 页码：3173-3185 , 文章类型： Article，,卷期：2011年30-15]
- The O-glycan branching enzyme, core2 beta-1,6-N-acetylglucosaminyltransferase (C2GnT), forms O-glycans containing an N-acetylglucosamine branch connected to N-acetylgalactosamine (core2 O-glycans) on cell-surface glycopr...
- Direct reprogramming of stem cell properties in colon cancer cells by CD44
[作者：Su, YJ; Lai, HM; Chang, YW; Chen, GY; Lee, JL,期刊：EMBO journal, 页码：3186-3199 , 文章类型： Article，,卷期：2011年30-15]
- Cancer progression is commonly segregated into processes of primary tumour growth and secondary metastasis. Recent evidence suggests that a subpopulation of cancer cells, cancer stem cells (CSCs), is responsible for tumo...
- Activation of Src and transformation by an RPTP alpha splice mutant found in human tumours
[作者：Huang, J; Yao, L; Xu, RT; Wu, HC; Wang, M; White, BS; Shalloway, D; Zheng, XM,期刊：EMBO journal, 页码：3200-3211 , 文章类型： Article，,卷期：2011年30-15]
- Receptor protein tyrosine phosphatase alpha (RPTP alpha)-mediated Src activation is required for survival of tested human colon and oestrogen receptor-negative breast cancer cell lines. To explore whether mutated RPTP al...
- Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles
[作者：Gomez-Gonzalez, B; Garcia-Rubio, M; Bermejo, R; Gaillard, H; Shirahige, K; Marin, A; Foiani, M; Aguilera, A,期刊：EMBO journal, 页码：3106-3119 , 文章类型： Article，,卷期：2011年30-15]
- THO/TREX is a conserved nuclear complex that functions in mRNP biogenesis and prevents transcription-associated recombination. Whether or not it has a ubiquitous role in the genome is unknown. Chromatin immunoprecipitati...
- Insensitive is a corepressor for Suppressor of Hairless and regulates Notch signalling during neural development
[作者：Duan, H; Dai, Q; Kavaler, J; Bejarano, F; Medranda, G; Negre, N; Lai, EC,期刊：EMBO journal, 页码：3120-3133 , 文章类型： Article，,卷期：2011年30-15]
- The Notch intracellular domain functions as a co-activator for the DNA-binding protein Suppressor of Hairless (Su(H)) to mediate myriad cell fate decisions. Notch pathway activity is balanced by transcriptional repressio...
- The functions of the actin nucleator Cobl in cellular morphogenesis critically depend on syndapin I
[作者：Schwintzer, L; Koch, N; Ahuja, R; Grimm, J; Kessels, MM; Qualmann, B,期刊：EMBO journal, 页码：3147-3159 , 文章类型： Article，,卷期：2011年30-15]
- Spatial control of cortical actin nucleation is indispensable for proper establishment and plasticity of cell morphology. Cobl is a novel WH2 domain-based actin nucleator. The cellular coordination of Cobl's nucleation a...
- Healthy ageing through regulated proteostasis
[作者：Rajalingam, K; Dikic, I,期刊：EMBO journal, 页码：2983-2985 , 文章类型： Editorial Material，,卷期：2011年30-15]
- During metazoan life, protein homeostasis (proteostasis) declines with age due to impaired proteasome activity. The signalling pathways activated by growth factors that regulate proteostasis and their importance to agein...
- Upward bound: follicular stem cell fate decisions
[作者：Horsley, V,期刊：EMBO journal, 页码：2986-2987 , 文章类型： Editorial Material，,卷期：2011年30-15]
- Recent data suggest that heterogeneous compartments of the bulge display differential gene expression, and supply cells to different lineages within the pilosebaceous unit (Jaks et al, 2008; Jensen et al, 2009; Snippert ...
- Signalling gets sorted by retromer
[作者：Spang, A,期刊：EMBO journal, 页码：2988-2989 , 文章类型： Editorial Material，,卷期：2011年30-15]
- Wnt proteins are secreted glycoproteins required for intercellular communication and important for development and tissue homoeostasis. Wnts are secreted through association to the sorting receptor Wntless, which promote...
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