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[摘要]：Wnt proteins are secreted glycoproteins required for intercellular communication and important for development and tissue homoeostasis. Wnts are secreted through association to the sorting receptor Wntless, which promotes transport of Wnt from the trans-Golgi network (TGN) to the plasma membrane. Harterink et al (2011) and Silhankova et al (2010) have investigated the intracellular recycling of the Wnt-sorting receptor and identified a novel retromer-dependent traffic route from early endosomes to the TGN that is dependent on the sorting nexin SNX3 and is regulated by PI3P levels on early endosomes. |
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