- Peoniflorin Prevents the Adhesion Between Inflammatory Endothelial Cells and Leukocytes Through Inhibiting the Activation of MAPKs and NF-kappa B
[作者:Xu, HA; Gao, XH; Song, L; Wang, FY; Xu, Z; Lu, D; Xu, XX; Xia, YF; Dai, Y,期刊:Drug Development Research, 页码:275-284 , 文章类型: Article,,卷期:2010年71-5]
- The vascular endothelium can be activated by multiple factors, including lipopolysaccharide (LPS) functioning as a key component of the inflammatory response. Activated endothelium promotes the recruitment of leukocytes ...
- Structure Activity Relationships of lsoeugenol-Based Chlorophenylpiperazine Derivatives on Serotonergic/Adrenergic Receptor, Platelet Aggregation, and Lipid Peroxidation
[作者:Shen, KP; Chang, WT; Lin, HL; Chu, LW; Chen, IJ; Wu, BN,期刊:Drug Development Research, 页码:285-293 , 文章类型: Article,,卷期:2010年71-5]
- Three isoeugenol-based eugenosedin chlorphenylpiperazine derivatives, Eu-A, Eu-B, and Eu-C, were synthesized and tested for their serotonergic, adrenergic antagonist, antioxidant, and antiaggregation activities. In radio...
- Synthesis and In Vitro Cytotoxic Activity on Human Anaplastic Thyroid Cancer Cells of Lipoamino Acid Conjugates of Gemcitabine
[作者:Pignatello, R; Vicari, L; Pistara, V; Musumeci, T; Gulisano, M; Puglisi, G,期刊:Drug Development Research, 页码:294-302 , 文章类型: Article,,卷期:2010年71-5]
- Lipophilic derivatives of the antitumor drug gemcitabine (GEM) with the potential for improving drug loading in lipid-based colloidal carriers, like liposomes or lipid nanoparticles, are described. GEM free base was conj...
- Effects of a Novel Class III Antiarrhythmic Agent, CPUY11018, on Rat Atrial Fibrillation
[作者:Guo, XA; Chen, CL; Yang, QA; Yin, YM; You, QD; Tang, YQ,期刊:Drug Development Research, 页码:303-312 , 文章类型: Article,,卷期:2010年71-5]
- CPUY11018 has anti-atrial fibrillation (AF) effects in rats. The effects of CPUY11018 on the transient outward K+ current (I-to) and ultra-rapid delayed rectifier K+ current (I-Kur) were studied using whole-cell patch cl...
- Effect of Nortriptyline on Cytosolic Ca2+ Regulation and Viability in PC3 Human Prostate Cancer Cells
[作者:Pan, CC; Shaw, CF; Huang, JK; Kuo, CC; Kuo, DH; Shieh, P; Lu, T; Chen, WC; Ho, CM; Jan, CR,期刊:Drug Development Research, 页码:323-330 , 文章类型: Article,,卷期:2010年71-5]
- The effect of nortriptyline, a tricyclic antidepressant, on Ca2+ regulation and viability in human prostate cancer cells (PC3) is unclear. The present study examined whether nortriptyline altered basal [ca(2+]); levels i...
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