[摘要]：CPUY11018 has anti-atrial fibrillation (AF) effects in rats. The effects of CPUY11018 on the transient outward K+ current (I-to) and ultra-rapid delayed rectifier K+ current (I-Kur) were studied using whole-cell patch clamp techniques and an acetylcholine (ACh)-CaCl2 induced AF model. CPUY11018 inhibited I-to and I-kur in a concentration-dependent manner with IC50 values of 18.5 and 1.7 mu M, respectively. Inhibition was independent of the depolarizing voltage. In the AF ACh-CaCl2 model, AF duration was effectively shortened after treatment with 5 mg/kg CPUY11018 for 4 days. These results indicate that CPUY11018 is effective in treating AF partly by blocking I-to and I-kur. Drug Dev Res 71:303-312, 2010. (C) 2010 Wiley-Liss, Inc.
