- Escherichia coil SlyD, More Than a Ni(II) Reservoir
[作者:Kaluarachchi, H; Zhang, JW; Zamble, DB,期刊:Biochemistry, 页码:10761-10763 , 文章类型: Article,,卷期:2011年50-50]
- SlyD interacts with HypB and contributes to nickel insertion during [NiFe]-hydrogenase biogenesis. Herein, we provide evidence of SlyD acting as a nickel storage determinant in Escherichia coli and show that this Ni(II) ...
- Full-Length Human Glutaminase in Complex with an Allosteric Inhibitor
[作者:DeLaBarre, B; Gross, S; Fang, C; Gao, Y; Jha, A; Jiang, F; Song, JJ; Wei, WT; Hurov, JB,期刊:Biochemistry, 页码:10764-10770 , 文章类型: Article,,卷期:2011年50-50]
- Glutaminase (GLS1/2) catalyzes the conversion of L-glutamine to L-glutamate and ammonia. The level of a splice variant of GLS1 (GAC) is elevated in certain cancers, and GAC is specifically inhibited by bis-2-(5-phenylace...
- Heme Ligand Identification and Redox Properties of the Cytochrome c Synthetase, CcmF
[作者:Francisco, BS; Bretsnyder, EC; Rodgers, KR; Kranz, RG,期刊:Biochemistry, 页码:10974-10985 , 文章类型: Article,,卷期:2011年50-50]
- Cytochrome c maturation in many bacteria, archaea, and plant mitochondria involves the integral membrane protein CcmF, which is thought to function as a cytochrome c synthetase by facilitating the final covalent attachme...
- Osteogenesis Imperfecta Missense Mutations in Collagen: Structural Consequences of a Glycine to Alanine Replacement at a Highly Charged Site
[作者:Xiao, JX; Cheng, HM; Silva, T; Baum, J; Brodsky, B,期刊:Biochemistry, 页码:10771-10780 , 文章类型: Article,,卷期:2011年50-50]
- Glycine is required as every third residue in the collagen triple helix, and a missense mutation leading to the replacement of even one Gly in the repeating (Gly-Xaa-Yaa)(n) sequence with a larger residue leads to a path...
- The Structural Basis for Homotropic and Heterotropic Cooperativity of Midazolam Metabolism by Human Cytochrome P450 3A4
[作者:Roberts, AG; Yang, J; Halpert, JR; Nelson, SD; Thummel, KT; Atkins, WM,期刊:Biochemistry, 页码:10804-10818 , 文章类型: Article,,卷期:2011年50-50]
- Human cytochrome P450 3A4 (CYP3A4) metabolizes a significant portion of clinically relevant drugs and often exhibits complex steady-state kinetics that can involve homotropic and heterotropic cooperativity between bound ...
- A Trimeric Supercomplex of the Oxygen-Tolerant Membrane-Bound [NiFe]-Hydrogenase from Ralstonia eutropha H16
[作者:Frielingsdorf, S; Schubert, T; Pohlmann, A; Lenz, O; Friedrich, B,期刊:Biochemistry, 页码:10836-10843 , 文章类型: Article,,卷期:2011年50-50]
- The oxygen-tolerant membrane-bound [NiFe]-hydrogenase (MBH) from Ralstonia eutropha H16 consists of three subunits. The large subunit HoxG carries the [NiFe] active site, and the small subunit HoxK contains three [FeS] c...
- Suppression of EGFR Autophosphorylation by FKBP12
[作者:Mathea, S; Li, S; Schierhorn, A; Jahreis, G; Schiene-Fischer, C,期刊:Biochemistry, 页码:10844-10850 , 文章类型: Article,,卷期:2011年50-50]
- FK506 binding proteins (FKBPs) represent a subfamily of peptidyl prolyl cis/trans isomerases that can control receptor-mediated intracellular signaling. The prototypic PPIase FKBP12 functionally interacts with EGFR. FKBP...
- Reconstitution of KCNE1 into Lipid Bilayers: Comparing the Structural, Dynamic, and Activity Differences in Micelle and Vesicle Environments
[作者:Coey, AT; Sahu, ID; Gunasekera, TS; Troxel, KR; Hawn, JM; Swartz, MS; Wickenheiser, MR; Reid, RJ; Welch, RC; Vanoye, CG; Kang, CB; Sanders, CR; Lorigan, GA,期刊:Biochemistry, 页码:10851-10859 , 文章类型: Article,,卷期:2011年50-50]
- KCNE1 (minK), found in the human heart and cochlea, is a transmembrane protein that modulates the voltage-gated potassium KCNQ1 channel. While KCNE1 has previously been the subject of extensive structural studies in lyso...
- Differential Roles of Cysteine Residues in the Cellular Trafficking, Dimerization, and Function of the High-Density Lipoprotein Receptor, SR-BI
[作者:Hu, J; Zhang, ZH; Shen, WJ; Nomoto, A; Azhar, S,期刊:Biochemistry, 页码:10860-10875 , 文章类型: Article,,卷期:2011年50-50]
- The scavenger receptor, class B, type I (SR-BI) binds high-density lipoprotein (HDL) and mediates selective delivery of cholesteryl esters (CEs) to the liver and steroidogenic cells of the adrenal glands and gonads. Alth...
- Secondary Nucleating Sequences Affect Kinetics and Thermodynamics of Tau Aggregation
[作者:Moore, CL; Huang, MH; Robbennolt, SA; Voss, KR; Combs, B; Gamblin, TC; Goux, WJ,期刊:Biochemistry, 页码:10876-10886 , 文章类型: Article,,卷期:2011年50-50]
- Tau protein was scanned for highly amyloidogenic sequences in amphiphilic motifs (X)(n)Z, Z(X)(n)Z (n >= 2), or (XZ)(n) (n >= 2), where X is a hydrophobic residue and Z is a charged or polar residue. N-Acetyl peptides ho...
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