- Exenatide once weekly for the treatment of type 2 diabetes
[作者:Malone, J; Trautmann, M; Wilhelm, K; Taylor, K; Kendall, DM,期刊:Expert opinion on investigational drugs, 页码:359-367 , 文章类型: Article,,卷期:2009年18-3]
- Exenatide is the first glucagon-like peptide-1 (GLP-1) receptor agonist approved for the treatment of type 2 diabetes mellitus (T2DM). Exenatide lowers blood glucose through multiple mechanisms, including enhancement of ...
- Highlights of regional meeting of Italian Southern Oncological Group (GOIM): focus on hepatocellular carcinoma: biological and clinical background, therapeutic guide-lines and perspectives
[作者:Addeo, R; Caraglia, M; Del Prete, S,期刊:Expert opinion on investigational drugs, 页码:373-378 , 文章类型: Article,,卷期:2009年18-3]
- This Italian meeting, co-sponsored by the Italian Southern Oncological Group (GOIM), focused on different aspects of hepatocellular carcinoma (HCC). Topics included epidemiological studies, identification of environmenta...
- Opioid formulations in development designed to curtail abuse: who is the target?
[作者:Webster, LR; Bath, B; Medve, RA,期刊:Expert opinion on investigational drugs, 页码:255-263 , 文章类型: Review,,卷期:2009年18-3]
- Background: Opioids are increasingly prescribed for chronic cancer and noncancer pain, and misuse, abuse, and diversion have risen dramatically. Formulations are being developed with the intent to curtail abuse through p...
- Caprospinol: moving from a neuroactive steroid to a neurotropic drug
[作者:Lecanu, L; Tillement, L; Rammouz, G; Tillement, JP; Grecson, J; Papadopoulos, V,期刊:Expert opinion on investigational drugs, 页码:265-276 , 文章类型: Review,,卷期:2009年18-3]
- In search of new drugs for Alzheimer's disease, we departed from the classic concepts and investigated the ability of normal and Alzheimer's disease brain to convert cholesterol to steroids, otherwise known as neurostero...
- Targeting multiple kinases in glioblastoma multiforme
[作者:Sathornsumetee, S; Reardon, DA,期刊:Expert opinion on investigational drugs, 页码:277-292 , 文章类型: Review,,卷期:2009年18-3]
- Glioblastoma multiforme (GBM), the most common primary malignant brain tumor in adults, is associated with high mortality. Current standard-of-care treatments, including surgery, radiation and chemotherapy, offer only pa...
- S-1: a promising new oral fluoropyrimidine derivative
[作者:Saif, MW; Syrigos, KN; Katirtzoglou, NA,期刊:Expert opinion on investigational drugs, 页码:335-348 , 文章类型: Review,,卷期:2009年18-3]
- The fluoropyrimidine anticancer agent 5-fluorouracil (5-FU) is active in a wide range of solid tumors, particularly gastric, colorectal, and head and neck cancers. Whilst infusional 5-FU is associated with higher respons...
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