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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共20条记录   Two Days of Experiments in Vietnam: Asian Chemical Biology Initiative, Hanoi Meeting [作者：MORII TAKASHII; UESUGI MOTONARI,期刊：ACS CHEMICAL BIOLOGY, 页码：623-625 , 文章类型： Editorial Material，,卷期：2012年7-4] Importance of the Cell Membrane on the Mechanism of Action of Cyclotides [作者：HENRIQUES SONIA TROEIRA; CRAIK DAVID J,期刊：ACS CHEMICAL BIOLOGY, 页码：626-636 , 文章类型： Review，,卷期：2012年7-4] Their distinctive structures, diverse range of bioactivities, and potential for pharmaceutical or agricultural applications make cyclotides an intriguing family of cyclic peptides. Together with teh physiological role in... Template-Assisted and Self-Activating Clicked Peptide as a Synthetic Mimic of the SH2 Domain [作者：TANAKA KATSUNORI; SHIROTSUKI SANAE; IWATA TAKAYUKI; KAGEYAMA CHIKA; TAHARA TSUYOSHI; NOZAKI SATOSHI; SIWU ERIC R O; TAMURA SATORU; DOUKE SHUNSUKE; MURAKAM NOBUTOSHI; ONOE HIROTAKA; WATANABE YASUYOSHI; FUKASE KOICHI,期刊：ACS CHEMICAL BIOLOGY, 页码：637-645 , 文章类型： Article，,卷期：2012年7-4] A new synthetic strategy for obtaining artificial receptors that selectively regulate and/or control specific protein/protein interactions was developed based on the template-assisted and the self-activating click reacti... Analysis of YM-216391 Biosynthetic Gene Cluster and Improvement of the Cyclopeptide Production in a Heterologous Host [作者：JIAN XIAOHONG; PAN HAIXUE; NIN TINGTING; SHI YUANYUAN; CHEN YONGSHENG; LI YAN; ZENG XIAOWEI; XU JIAN; TANG GONGLI,期刊：ACS CHEMICAL BIOLOGY, 页码：646-651 , 文章类型： Article，,卷期：2012年7-4] YM-216391, an autitumor natural product, represents a new class of cyclic peptides containing a polyoxazolethiazole moiety, Herein we describe its gene cluster encoding the biosynthetic paradigm featuring a ribosomally s... Wild Type, Mutant Protein Unfolding and Phase Transition Detected by Single-Nanopore Recording [作者：MERSTORF CELINE; CRESSIOT BENJAMIN; PASTORIZAGALLEGO MANUELA; OUKHALED ABDELGHANI; BETTON JEANMICHEL; AUVRAY LOIC; PELTA JUAN,期刊：ACS CHEMICAL BIOLOGY, 页码：652-658 , 文章类型： Article，,卷期：2012年7-4] Understanding protein folding remains a challenge. A difficulty is to investigate experimentally all the conformations in the energy landscape. Only single molecule methods, fluorescence and force spectroscopy, allow obs... Vibrio cholerae Autoinducer CAI-1 Interferes with Pseudomonas aeruginosa Quorum Sensing and Inhibits its Growth [作者：GANIN HADAS; DANINPOLEG YAEL; KASHI YECHEZKEL; MEIJLER MICHAEL M,期刊：ACS CHEMICAL BIOLOGY, 页码：659-665 , 文章类型： Article，,卷期：2012年7-4] The human,patliogen. Vibrio cholerae uses several small molecules to coordinate gene expression in a process termed quorum sensing (QS), and its main auto-inducer is CAI-1 We have examined the activity of this signaling ... Iron(III) Protoporphyrin IX Complexes of the Antimalarial Cinchona Alkaloids Quinine and Quinidine [作者：DE VILLIERS KATHERINE A; GILDENHUYS JOHANDIE; LE ROEX TANYA,期刊：ACS CHEMICAL BIOLOGY, 页码：666-671 , 文章类型： Article，,卷期：2012年7-4] The antimalarial properties of the Cinchona alkaloids quinine and quinidine have been known for decades. Surprisingly, 9-epiquinine and 9-epiquinidine are almost inactive. A lack of definitive structural information has ... Identification of SR2211: A Potent Synthetic ROR gamma-Selective Modulator [作者：KUMAR NARESH; LYDA BRENT; CHANG MI RA; LAUER JANELLE L; SOLT LAURA A; BURRIS THOMAS P; KAMENECKA THEODORE M; GRIFFIN PATRICK R,期刊：ACS CHEMICAL BIOLOGY, 页码：672-677 , 文章类型： Article，,卷期：2012年7-4] Nuclear receptors (NRs) are ligand-regulated transcription factors that display canonical domain structure with highly conserved DNA binding and ligand binding domains. The identification of the endogenous ligands for se... Mechanism of Cell Cycle. Entry Mediated by the Intrinsically Disordered Protein p27(Kip1) [作者：OU LI; WADDELL M BRETT; KRIWACKI RICHARD W,期刊：ACS CHEMICAL BIOLOGY, 页码：678-682 , 文章类型： Article，,卷期：2012年7-4] p27(Kip1) (p27), a prototypical intrinsically disordered protein (IDP), regulates eukaryotic cell division through interactions with cyclin-dependent kinase (Cdk)/cyclin complexes. The activity, stability and subcellular... Surface Labeling of Enveloped Viruses Assisted by Host Cells [作者：HUANG BIHAI; LIN YI; ZHANG ZHILING; ZHUAN FANGFANG; LIU ANAN; XIE MIN; TIAN ZHIQUAN; ZHANG ZHENFENG; WANG HANZHONG; PANG DAIWEN,期刊：ACS CHEMICAL BIOLOGY, 页码：683-688 , 文章类型： Article，,卷期：2012年7-4] Labeling of virus opens new pathways for the understanding of viruses themselves and facilitates the utilization of viruses in modern biology, medicine, and materials. Based on the characteristic that viruses hijack thei... A Synthetic Recursive "+1" Pathway for Carbon Chain Elongation [作者：MARCHESCHI RYAN J; LI HAN; ZHANG KECHUN; NOEY ELIZABETH L; KIM SEONAH; CHAUBEY ASHA; HOUK K N; LIAO JAMES C,期刊：ACS CHEMICAL BIOLOGY, 页码：689-697 , 文章类型： Article，,卷期：2012年7-4] Nature uses four methods of carbon chain elongation for the production of 2-ketoacid, fatty acids, polyketides, and isoprenoids. Using a combination of quantum mechanical (QM) modeling protein-substrate modeling, and pro... A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A [作者：MARTIN MATHEW P; ZHU JINYI; LAWRENCE HARSHANI R; PIREDDU ROBERTA; LUO YUNTING; ALAM RIAZUL; OZCAN SEVIL; SEBTI SAID M; LAWRENCE NICHOLAS J; SCHOENBRUNN ERNST,期刊：ACS CHEMICAL BIOLOGY, 页码：698-706 , 文章类型： Article，,卷期：2012年7-4] Most protein kinases share a DFG (Asp-Phe-Gly) motif in the ATP site that can assume two distinct conformations, the active DFG-in and the inactive DFG-out states. Small molecule inhibitors able to induce the DFG-out sta... Targeting and Maturation of Erv1/ALR in the Mitochondrial Intermembrane Space [作者：KALLERGI EMMANOUELA; ANDREADAKI MARIA; KRITSILIGKOU PARASKEVI; KATRAKILI NITSA; POZIDIS CHARALAMBOS; TOKATLIDIS KOSTAS; BANCI LUCIA; BERTINI IVANO; CEFARO CHIARA; CIOFIBAFFONI SIMONE; GAJDA KAROLINA; PERUZZINI RICCARDO,期刊：ACS CHEMICAL BIOLOGY, 页码：707-714 , 文章类型： Article，,卷期：2012年7-4] The interaction of Mia40 with Erv1/ALR is central to the oxidative:, protein folding in the intermembrane space of mitochondria (IMS) as Erv1/ALR oxidizes reduced Mia40 to restore its functional state. Here we address th... Identification of a Small Molecule Yeast TORC1 Inhibitor with a Multiplex Screen Based on Flow Cytometry [作者：CHEN JUN; YOUNG SUSAN M; ALLEN CHRIS; SEEBER ANDREW; PELIGULLI MARIEPIERRE; PANCHAUD NICOLAS; WALLER ANNA; URSU OLEG; YAO TUANLI; GOLDEN JENNIFER E; STROUSE J JACOB; CARTER MARK B; KANG HUINING; BOLOGA CRISTIAN G; FOUTZ TERRY D; EDWARDS BRUCE S; PETERSON BLAKE R; AUBE JEFFREY; WERNERWASHBURNE MARGARET; LOEWITH ROBBIE J; DE VIRGILIO CLAUDIO; SKLAR LARRY A,期刊：ACS CHEMICAL BIOLOGY, 页码：715-722 , 文章类型： Article，,卷期：2012年7-4] TOR (target of rapamycin) is a serine/threonine kinase, evolutionarily conserved from yeast to human, which functions as a fundamental controller of cell growth. The moderate clinical benefit of rapamycin in mTOR-based: ... A Chemical Genetic Approach for Covalent Inhibition of Analogue-Sensitive Aurora Kinase [作者：KOCH ANDRE; RODE HARIDAS B; RICHTERS ANDRE; RAUH DANIEL; HAUF SILKE,期刊：ACS CHEMICAL BIOLOGY, 页码：723-731 , 文章类型： Article，,卷期：2012年7-4] The perturbation of protein kinases with small organic molecules is a powerful approach to dissect kinase function in complex biological systems. Covalent kinase inhibitors that target thiols in the ATP binding pocket of... Small Molecules That Recapitulate the Early Steps of Urodele Amphibian Limb Regeneration and Confer Multipotency [作者：KIM WOONGHEE; JUNG DAWOON; KIM JINMI; IM SINHYEOG; HWANG SEUNG YONG; WILLIAMS DARREN R,期刊：ACS CHEMICAL BIOLOGY, 页码：732-743 , 文章类型： Article，,卷期：2012年7-4] In urodele amphibians, an early step in limb regeneration is skeletal muscle fiber dedifferentiation into a cellulate that proliferates to contribute new limb tissue. However, Mammalian muscle cannot dedifferentiate afte...