Vibrio cholerae Autoinducer CAI-1 Interferes with Pseudomonas aeruginosa Quorum Sensing and Inhibits its Growth

[摘要]：The human,patliogen. Vibrio cholerae uses several small molecules to coordinate gene expression in a process termed quorum sensing (QS), and its main auto-inducer is CAI-1 We have examined the activity of this signaling molecule in three other species of bacteria. Interestingly, while showing an inhibitory effect on QS, in the opportunistic pathogen P. aeruginosa at low micromolar concentrations, it caused also growth inhibition at higher concentrations. In contrast, the two other bacteria were Unaffected and we suggest a possible mechanism for these effects, based on membrane perturbation studies.

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