Importance of the field: Clostridium difficile infection (CDI) is associated with consumption of antibiotics which disrupt the normal microbial flora of the gut, allowing C. difficile to establish itself and produce dise...
Importance of the field: The rising levels of antibiotic resistance in pathogenic microorganisms create an urgent need for new antimicrobial agents that are not affected by resistance mechanisms already present in the ba...
The rapidly escalating prevalence of antimicrobial resistance is a global concern. This reduced susceptibility to currently available antimicrobial agents coupled with the progressive shortage of newly approved compounds...
Importance of the field: Nosocomial infections caused by multi-drug resistant (MDR) Gram-negative bacteria are on the increase, often with few or no therapeutic options for treatment. Historically, a successful approach ...
Importance of the field: beta-Lactam antibiotics are among the most frequently prescribed antibiotics used to treat bacterial infections. However, their utility is being threatened by the worldwide proliferation of beta-...
Importance of the field: The quinolone class of antibacterial agents has a proven track record over the past several decades for the treatment of bacterial infections. Their unique mechanism of action and bactericidal pr...
Importance of the field: Current antibiotics have classically been developed to treat infections involving planktonic bacterial populations in acute infection settings and are typically ineffective in the eradication of ...
Importance of the field: New antibiotics are needed to overcome microbial resistance and to improve on the therapeutic index and clinical effectiveness of existing agents. Area covered in this review: This review covers ...
Importance of the field: Fermentation-derived natural products have been a traditional source of antibiotics and antibiotic leads. Most of these discoveries were made about 50 years ago and continue to serve as leads for...