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[摘要]：Importance of the field: New antibiotics are needed to overcome microbial resistance and to improve on the therapeutic index and clinical effectiveness of existing agents. Area covered in this review: This review covers the journal and patent literature published from about the mid-2000s to 2010 to provide an overview of the large diversity of new chemical entities in the macrolide, lincosaminide and streptogramin B (MLSB) class. What the reader will gain: The review identifies areas of the greatest effort and recent results in pursuing structure-activity relationships among MLSB antibiotics and highlights preclinical and clinical candidates that have arisen from these diverse discovery programs. Take home message: Research on the MLSB class appears promising for the eventual registration and commercialization of several new antibiotics that improve the clinical effectiveness of existing agents and combat antibiotic-resistant pathogens. |
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