- Selective expression of Kras(G12D) in granulosa cells of the mouse ovary causes defects in follicle development and ovulation
[作者:Fan, HY; Shimada, M; Liu, Z; Cahill, N; Noma, N; Wu, Y; Gossen, J; Richards, JS,期刊:Development, 页码:2127-2137 , 文章类型: Article,,卷期:2008年135-12]
- Activation of the RAS family of small G-proteins is essential for follicle stimulating hormone-induced signaling events and the regulation of target genes in cultured granulosa cells. To analyze the functions of RAS prot...
- C3G regulates cortical neuron migration, preplate splitting and radial glial cell attachment
[作者:Voss, AK; Britto, JM; Dixon, MP; Sheikh, BN; Collin, C; Tan, SS; Thomas, T,期刊:Development, 页码:2139-2149 , 文章类型: Article,,卷期:2008年135-12]
- Neuronal migration is integral to the development of the cerebral cortex and higher brain function. Cortical neuron migration defects lead to mental disorders such as lissencephaly and epilepsy. Interaction of neurons wi...
- Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate
[作者:Zhang, Y; Andl, T; Yang, SH; Teta, M; Liu, F; Seykora, JT; Tobias, JW; Piccolo, S; Schmidt-Ullrich, R; Nagy, A; Taketo, MM; Dlugosz, AA; Millar, SE,期刊:Development, 页码:2161-2172 , 文章类型: Article,,卷期:2008年135-12]
- beta-Catenin signaling is required for hair follicle development, but it is unknown whether its activation is sufficient to globally program embryonic epidermis to hair follicle fate. To address this, we mutated endogeno...
- Multiple modular promoter elements drive graded brinker expression in response to the Dpp morphogen gradient
[作者:Yao, LC; Phin, S; Cho, J; Rushlow, C; Arora, K; Warrior, R,期刊:Development, 页码:2183-2192 , 文章类型: Article,,卷期:2008年135-12]
- Morphogen gradients play fundamental roles in patterning and cell specification during development by eliciting differential transcriptional responses in target cells. In Drosophila, Decapentaplegic (Dpp), the BMP2/4 hom...
- Cell-autonomous requirement for beta 1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice
[作者:Carlson, TR; Hu, HQ; Braren, R; Kim, YH; Wang, RA,期刊:Development, 页码:2193-2202 , 文章类型: Article,,卷期:2008年135-12]
- beta 1 integrin (encoded by Itgb1) is established as a regulator of angiogenesis based upon the phenotypes of complete knockouts of beta 1 heterodimer partners or ligands and upon antibody inhibition studies in mice. Its...
- Cell cycle progression is required for zebrafish somite morphogenesis but not segmentation clock function
[作者:Zhang, LX; Kendrick, C; Julich, D; Holley, SA,期刊:Development, 页码:2065-2070 , 文章类型: Article,,卷期:2008年135-12]
- Cell division, differentiation and morphogenesis are coordinated during embryonic development, and frequently are in disarray in pathologies such as cancer. Here, we present a zebrafish mutant that ceases mitosis at the ...
- Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth
[作者:Simmons, DG; Natale, DRC; Begay, V; Hughes, M; Leutz, A; Cross, JC,期刊:Development, 页码:2083-2091 , 文章类型: Article,,卷期:2008年135-12]
- The labyrinth of the rodent placenta contains villi that are the site of nutrient exchange between mother and fetus. They are covered by three trophoblast cell types that separate the maternal blood sinusoids from fetal ...
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