- Induction of human microsomal prostaglandin E synthase 1 by activated oncogene RhoA GTPase in A549 human epithelial cancer cells
[作者:Choi, HJ; Lee, DH; Park, SH; Kim, J; Do, KH; An, TJ; Ahn, YS; Park, CB; Moon, Y,期刊:Biochemical and Biophysical Research Communications, 页码:448-453 , 文章类型: Article,,卷期:2011年413-3]
- Oncogenic RhoA GTPase has been investigated as a mediator of pro-inflammatory responses and aggressive carcinogenesis. Among the various targets of RhoA-linked signals, pro-inflammatory prostaglandin E(2) (PGE(2)), a maj...
- Voluntary exercise attenuates obesity-associated inflammation through ghrelin expressed in macrophages
[作者:Kizaki, T; Maegawa, T; Sakurai, T; Ogasawara, JE; Ookawara, T; Oh-ishi, S; Izawa, T; Haga, S; Ohno, H,期刊:Biochemical and Biophysical Research Communications, 页码:454-459 , 文章类型: Article,,卷期:2011年413-3]
- Chronic low-level inflammation is associated with obesity and a sedentary lifestyle, causing metabolic disturbances such as insulin resistance. Exercise training has been shown to decrease chronic low-level systemic infl...
- Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction
[作者:Gomez-Bougie, P; Menoret, E; Juin, P; Dousset, C; Pellat-Deceunynck, C; Amiot, M,期刊:Biochemical and Biophysical Research Communications, 页码:460-464 , 文章类型: Article,,卷期:2011年413-3]
- The level of the Mcl-1 pro-survival protein is highly regulated, and the down-regulation of Mcl-1 expression favors the apoptotic process. Mcl-1 physically interacts with different BH3-only proteins: particularly, Noxa i...
- High fat diet induced insulin resistance and glucose intolerance are gender-specific in IGF-1R heterozygous mice
[作者:Garg, N; Thakur, S; McMahan, CA; Adamo, ML,期刊:Biochemical and Biophysical Research Communications, 页码:476-480 , 文章类型: Article,,卷期:2011年413-3]
- Interactions between genes and environment play a critical role in the pathogenesis of type 2 diabetes. Low birth weight, due to genetic and environmental variables affecting fetal growth, is associated with increased su...
- Alternative splicings on p53, BRCA1 and PTEN genes involved in breast cancer
[作者:Okumura, N; Yoshida, H; Kitagishi, Y; Nishimura, Y; Matsuda, S,期刊:Biochemical and Biophysical Research Communications, 页码:395-399 , 文章类型: Review,,卷期:2011年413-3]
- Alternative splicing is a major contributor to transcriptome and proteome diversity, which can lead to the deregulation of crucial cellular processes and have been associated with a variety of human diseases including ca...
- Npc1 deficiency in the C57BL/6J genetic background enhances Niemann-Pick disease type C spleen pathology
[作者:Parra, J; Klein, AD; Castro, J; Morales, MG; Mosqueira, M; Valencia, I; Cortes, V; Rigotti, A; Zanlungo, S,期刊:Biochemical and Biophysical Research Communications, 页码:400-406 , 文章类型: Article,,卷期:2011年413-3]
- Niemann-Pick type C (NPC) disease is an autosomal recessive neurovisceral lipid storage disorder. The affected genes are NPC1 and NPC2. Mutations in either gene lead to intracellular cholesterol accumulation. There are t...
- Palmitate alters the rhythmic expression of molecular clock genes and orexigenic neuropeptide Y mRNA levels within immortalized, hypothalamic neurons
[作者:Fick, LJ; Fick, GH; Belsham, DD,期刊:Biochemical and Biophysical Research Communications, 页码:414-419 , 文章类型: Article,,卷期:2011年413-3]
- The control of energy homeostasis within the hypothalamus is under the regulated control of homeostatic hormones, nutrients and the expression of neuropeptides that alter feeding behavior. Elevated levels of palmitate, a...
- Irregular electrical activation of intrinsic cardiac adrenergic cells increases catecholamine-synthesizing enzymes
[作者:Saygili, E; Gunzel, C; Saygili, E; Noor-Ebad, F; Schwinger, RHG; Mischke, K; Marx, N; Schauerte, P; Rana, OR,期刊:Biochemical and Biophysical Research Communications, 页码:432-435 , 文章类型: Article,,卷期:2011年413-3]
- Background: Recently, increased cardiac norepinephrine levels were observed in patients who were exposed to irregular stimulation during electrophysiological testing. The molecular mechanisms remain unclear. Intrinsic ca...
- Bone morphogenetic protein-2 activates NADPH oxidase to increase endoplasmic reticulum stress and human coronary artery smooth muscle cell calcification
[作者:Liberman, M; Johnson, RC; Handy, DE; Loscalzo, J; Leopold, JA,期刊:Biochemical and Biophysical Research Communications, 页码:436-441 , 文章类型: Article,,卷期:2011年413-3]
- Bone morphogenetic protein-2 (BMP-2) increases oxidant stress and endoplasmic reticulum (ER) stress to stimulate differentiation of osteoblasts; however, the role of these signaling pathways in the transition of smooth m...
- Development of a fluorescently labeled thermostable DHFR for studying conformational changes associated with inhibitor binding
[作者:Goodey, NM; Alapa, MT; Hagmann, DF; Korunow, SG; Mauro, AK; Kwon, KS; Hall, SM,期刊:Biochemical and Biophysical Research Communications, 页码:442-447 , 文章类型: Article,,卷期:2011年413-3]
- A fluorescently-labeled, conformationally-sensitive Bacillus stearothermophilus (Bs) dihydrofolate reductase (DHFR) (C73A/S131C(MDCC) DHFR) was developed and used to investigate kinetics and protein conformational motion...
- Mutation of calcineurin subunit B M118 influences the activities of NF-AT and p53, but not calcineurin expression level
[作者:Cheng, JB; Tang, W; Su, ZY; Wei, Q,期刊:Biochemical and Biophysical Research Communications, 页码:481-486 , 文章类型: Article,,卷期:2011年413-3]
- Calcineurin (CN) is a Ca(2+)/calmodulin-dependent phosphatase, which consists of a catalytic A-subunit (CnA) and a regulatory B-subunit (CnB). Endogenous CnA and CnB have a strong corelationship in cancer cell lines. Thr...
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