- An alignment independent 3D QSAR study of the antiproliferative activity of 1,2,4,5-tetraoxanes
[作者:Cvijetic, IN; Zizak, ZP; Stanojkovic, TP; Juranic, ZD; Terzic, N; Opsenica, IM; Opsenica, DM; Juranic, IO; Drakulic, BJ,期刊:European Journal of Medicinal Chemistry, 页码:4570-4577 , 文章类型: Article,,卷期:2010年45-10]
- An alignment-free 3D QSAR study on antiproliferative activity of the thirty-three 1,2,4,5-tetraoxane derivatives toward two human dedifferentiated cell lines was reported. GRIND methodology, where descriptors are derived...
- Schiff bases of indoline-2,3-dione (isatin) derivatives and nalidixic acid carbohydrazide, synthesis, antitubercular activity and pharmacophoric model building
[作者:Aboul-Fadl, T; Bin-Jubair, FAS; Aboul-Wafa, O,期刊:European Journal of Medicinal Chemistry, 页码:4578-4586 , 文章类型: Article,,卷期:2010年45-10]
- Tuberculosis (TB) remains among the world's great public health challenges. Worldwide resurgence of TB is due to two major problems. the AIDS epidemic, which started in the mid-1980s, and the outbreak of multidrug resist...
- Synthesis and biological property of some novel 1,3,4-oxadiazoles
[作者:Ramaprasad, GC; Kalluraya, B; Kumar, BS; Hunnur, RK,期刊:European Journal of Medicinal Chemistry, 页码:4587-4593 , 文章类型: Article,,卷期:2010年45-10]
- A series of biphenyl-1,3,4-oxadiazoles namely 5-[substituted-(1,1'-biphenyl)-3-yl]-1,3,4-oxadiazole-2 (3H)-thiones and its S-alkyl derivatives have been synthesized by multi step organic synthesis involving Suzuki-Miyaur...
- Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2
[作者:Giordano, C; Sansone, A; Masi, A; Lucente, G; Punzi, P; Mollica, A; Pinnen, F; Feliciani, F; Cacciatore, I; Davis, P; Lai, J; Ma, SW; Porreca, F; Hruby, V,期刊:European Journal of Medicinal Chemistry, 页码:4594-4600 , 文章类型: Article,,卷期:2010年45-10]
- The opioid agonists endomorphins (Tyr-Pro-Trp-Phe-NH2; EM1 and Tyr-Pro-Phe-Phe-NH2; EM2) and morphiceptin (Tyr-Pro-Phe-Pro-NH2) exhibit an extremely high selectivity for mu-opioid receptor. Here a series of novel EM2 and...
- Synthesis and antimycobacterial activity of new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives
[作者:Moreno, E; Ancizu, S; Perez-Silanes, S; Torres, E; Aldana, I; Monge, A,期刊:European Journal of Medicinal Chemistry, 页码:4418-4426 , 文章类型: Article,,卷期:2010年45-10]
- As a continuation of our research and with the aim of obtaining new anti-tuberculosis agents which can improve the current chemotherapeutic anti-tuberculosis treatments, forty-three new quinoxaline-2-carboxamide 1,4-di-N...
- Synthesis and CYP24A1 inhibitory activity of (E)-2-(2-substituted benzylidene)- and 2-(2-substituted benzyl)-6-methoxy-tetralones
[作者:Aboraia, AS; Makowski, B; Bahja, A; Prosser, D; Brancale, A; Jones, G; Simons, C,期刊:European Journal of Medicinal Chemistry, 页码:4427-4434 , 文章类型: Article,,卷期:2010年45-10]
- A series of (E)-2-(2-substituted benzylidene)- and 2-(2-substituted benzyl)-6-methoxy-tetralones were prepared, using an efficient synthetic scheme, and evaluated for their inhibitory activity against cytochrome P450C24A...
- Synthesis and antifungal evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14 alpha-demethylase
[作者:Yu, SC; Chai, XY; Hu, HG; Yan, YZ; Guan, ZJ; Zou, Y; Sun, QY; Wu, QY,期刊:European Journal of Medicinal Chemistry, 页码:4435-4445 , 文章类型: Article,,卷期:2010年45-10]
- A series of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols (1a-v, 2a-w), which are analogues of fluconazole. have been designed and synthesized as the potential antifungal agents by the click ...
- Isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity
[作者:Changtam, C; Hongmanee, P; Suksamrarn, A,期刊:European Journal of Medicinal Chemistry, 页码:4446-4457 , 文章类型: Article,,卷期:2010年45-10]
- Curcumin (1), demethoxycurcumin (2) and bisdemethoxycurcumin (3), the curcuminoid constituents of the medicinal plant Curcuma longa L, have been structurally modified to 55 analogs and antimycobacterial activity against ...
- Synthesis, molecular docking and biological evaluation of Schiff base transition metal complexes as potential urease inhibitors
[作者:Chen, W; Li, YG; Cui, YM; Zhang, XA; Zhu, HL; Zeng, QF,期刊:European Journal of Medicinal Chemistry, 页码:4473-4478 , 文章类型: Article,,卷期:2010年45-10]
- Six transition metal compounds of Schiff base ligands were evaluated for the inhibitory activity on jack bean urease, of which compounds 2-6 were determined by single crystal X-ray analysis. It was found that copper(II) ...
- Synthesis of new series of quinoxaline based MAO-inhibitors and docking studies
[作者:Khattab, SN; Hassan, SY; Bekhit, AA; El Massry, AM; Langer, V; Amer, A,期刊:European Journal of Medicinal Chemistry, 页码:4479-4489 , 文章类型: Article,,卷期:2010年45-10]
- A series of 2-benzy1-3-(2-arylidenehydrazinyl)quinoxalines 3, 4-benzyl-1-aryl-(1,2,4]triazolo[4,3-a]quinoxalines 4 and phenyl(1-aryl-[1,2,4]triazolo[4,3-a]quinoxalin-4-yl)methanones 5 analogues were synthesized and inves...
- Synthesis of new 3-aryl-4,5-dihydropyrazole-1-carbothioamide derivatives. An investigation on their ability to inhibit monoamine oxidase
[作者:Maccioni, E; Alcaro, S; Orallo, F; Cardia, MC; Distinto, S; Costa, G; Yanez, M; Sanna, ML; Vigo, S; Meleddu, R; Secci, D,期刊:European Journal of Medicinal Chemistry, 页码:4490-4498 , 文章类型: Article,,卷期:2010年45-10]
- Some differently substituted 3-aryl-4,5-dihydropyrazoles-1-carbothioamides have been synthesised with the aim to investigate their monoamine oxidase inhibitory activity. The chemical structures of the compounds have been...
- QSAR study of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2 using LS-SVM and GRNN based on principal components
[作者:Shahlaei, M; Sabet, R; Ziari, MB; Moeinifard, B; Fassihi, A; Karbakhsh, R,期刊:European Journal of Medicinal Chemistry, 页码:4499-4508 , 文章类型: Article,,卷期:2010年45-10]
- Quantitative relationships between molecular structure and methionine aminopeptidase-2 inhibitory activity of a series of cytotoxic anthranilic acid sulfonamide derivatives were discovered. We have demonstrated the detai...
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