- Impact of the Nature of the Substituent at the 3-Position of 4H-1,2,4-Benzothiadiazine 1,1-Dioxides on Their Opening Activity toward ATP-Sensitive Potassium Channels
[作者:PIROTTE BERNARD; DE TULLIO PASCAL; BOVERIE STEPHANE; MICHAUX CATHERINE; LEBRUN PHILIPPE,期刊:Journal of Medicinal Chemistry, 页码:3188-3199 , 文章类型: Article,,卷期:2011年54-9]
- The synthesis of diversely substituted 3-isopropoxy-, 3-isopropylsulfanyl-, 3-isopropylsulfinyl-, and 3-isobutyl-4H-1,2,4-benzothiadiazine 1,1-dioxides is described. Their activity on pancreatic beta-cells (inhibitory ef...
- Discovery of 2-Arylbenzoxazoles as Upregulators of Utrophin Production for the Treatment of Duchenne Muscular Dystrophy
[作者:CHANCELLOR DANIEL R; DAVIES KAY E; DE MOOR OLIVIER; DORGAN COLIN R; JOHNSON PETER D; LAMBERT ADAM G; LAWRENCE DANIEL; LECCI CRISTINA; MAILLOL CAROLE; MIDDLETON PENNY J; NUGENT GARY; POIGNANT SEVERINE D; POTTER ALLYSON C; PRICE PAUL D; PYE RICHARD J; STORER RICHARD; TINSLEY JONATHON M; VAN WELL RENATE; VICKERS RICHARD; VILE JULIA; WILKES FRASER J; WILSON FRANCIS X; WREN STEPHEN P; WYNNE GRAHAM M,期刊:Journal of Medicinal Chemistry, 页码:3241-3250 , 文章类型: Article,,卷期:2011年54-9]
- A series of novel 2-arylbenzoxazoles that upregulate the production of utrophin in murine H2K cells, as assessed using a luciferase reporter linked assay, have been identified. This compound class appears to hold conside...
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