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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共10条记录   Targeted anticancer therapies: Mouse models help uncover the mechanisms of tumor escape [作者：van Amerongen, R; Berns, A,期刊：Cancer Cell, 页码：5-7 , 文章类型： Editorial Material，,卷期：2008年13-1] In contrast to conventional chemotherapeutic agents, modern anticancer therapies are aimed at attacking specific targets in a tumor. While these therapies show promising clinical effects, their success is limited by the ... Autocrine IL-6 signaling: A key event in tumorigenesis? [作者：Grivennikov, S; Karin, M,期刊：Cancer Cell, 页码：7-9 , 文章类型： Editorial Material，,卷期：2008年13-1] Tumorigenesis is a multistep process that requires constitutive cell division, growth, and survival. One strategy used by cancer cells to upregulate growth and survival pathways is through autocrine production of growth ... An E2F1-dependent gene expression program that determines the balance between proliferation and cell death [作者：Hallstrom, TC; Mori, S; Nevins, JR,期刊：Cancer Cell, 页码：11-22 , 文章类型： Article，,卷期：2008年13-1] The Rb/E2F pathway regulates the expression of genes essential for cell proliferation but that also trigger apoptosis. During normal proliferation, PI3K/Akt signaling blocks E2F1-induced apoptosis, thus serving to balanc... Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis [作者：Yang, L; Huang, JH; Ren, XB; Gorska, AE; Chytil, A; Aakre, M; Carbone, DP; Matrisian, LM; Richmond, A; Lin, PC; Mosesl, HL,期刊：Cancer Cell, 页码：23-35 , 文章类型： Article，,卷期：2008年13-1] Aberrant TGF beta signaling is common in human cancers and contributes to tumor metastasis. Here, we demonstrate that Gr-1+CD11b+ myeloid cells are recruited into mammary carcinomas with type II TGF beta receptor gene (T... GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers [作者：Kang, T; Wei, Y; Honaker, Y; Yamaguchi, H; Appella, E; Hung, MC; Piwnica-Worms, H,期刊：Cancer Cell, 页码：36-47 , 文章类型： Article，,卷期：2008年13-1] The Cdc25A phosphatase positively regulates cell-cycle transitions, is degraded by the proteosome throughout interphase and in response to stress, and is overproduced in human cancers. The kinases targeting Cdc25A for pr... MicroRNA signature predicts survival and relapse in lung cancer [作者：Yu, SL; Chen, HY; Chang, GC; Chen, CY; Chen, HW; Singh, S; Cheng, CL; Yu, CJ; Lee, YC; Chen, HS; Su, TJ; Chiang, CC; Li, HN; Hong, QS; Su, HY; Chen, CC; Chen, WJ; Liu, CC; Chan, WK; Chen, WJ; Li, KC; Chen, JJW; Yang, PC,期刊：Cancer Cell, 页码：48-57 , 文章类型： Article，,卷期：2008年13-1] We investigated whether microRNA expression profiles can predict clinical outcome of NSCLC patients. Using real-time RT-PCR, we obtained microRNA expressions in 112 NSCLC patients, which were divided into the training an... Systemic spread is an early step in breast cancer [作者：Husemann, Y; Geigl, JB; Schubert, F; Musiani, P; Meyer, M; Burghart, E; Forni, G; Eils, R; Fehm, T; RiethmUller, G; Klein, CA,期刊：Cancer Cell, 页码：58-68 , 文章类型： Article，,卷期：2008年13-1] It is widely accepted that metastasis is a late event in cancer progression. Here, however, we show that tumor cells can disseminate systemically from earliest epithelial alterations in HER-2 and PyMT transgenic mice and... Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells [作者：Lee, J; Son, MJ; Woolard, K; Donin, NM; Li, A; Cheng, CH; Kotliarova, S; Kotliarov, Y; Walling, J; Ahn, S; Kim, M; Totonchy, M; Cusack, T; Ene, C; Ma, H; Su, Q; Zenklusen, JC; Zhang, W; Maric, D; Fine, HA,期刊：Cancer Cell, 页码：69-80 , 文章类型： Article，,卷期：2008年13-1] Despite similarities between tumor-initiating cells with stem-like properties (TICs) and normal neural stem cells, we hypothesized that there may be differences in their differentiation potentials. We now demonstrate tha... Live or let die: E2F1 and PI3K pathways intersect to make life or death decisions [作者：Dyniacht, BD,期刊：Cancer Cell, 页码：1-2 , 文章类型： Editorial Material，,卷期：2008年13-1] In the current issue of Cancer Cell, Hallstrom et al. show that a subset of targets of the growth regulatory transcription factor E2F1 are repressed by a serum-induced PI3K activation, explaining how apoptosis can be sup... BMPing off glioma stem cells [作者：Nakano, I; Saigusa, K; Kornblum, HI,期刊：Cancer Cell, 页码：3-4 , 文章类型： Editorial Material，,卷期：2008年13-1] Brain tumor stem cells (BTSC) bear some similarities to neural stem cells (NSC). Bone morphogenetic proteins (BMPs) have a proproliferative effect on early embryonic NSC, and a prodifferentiative effect on postnatal NSC....