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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共11条记录   Cancer cells display intra- and interline variation profound following prolonged exposure to antimitotic drugs [作者：Gascoigne, KE; Taylor, SS,期刊：Cancer Cell, 页码：111-122 , 文章类型： Article，,卷期：2008年14-2] Drugs targeting the mitotic spindle are used extensively during chemotherapy, but surprisingly, little is known about how they kill tumor cells. This is largely because many of the population-based approaches are indirec... Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma [作者：Schuller, U; Heine, VM; Mao, J; Kho, AT; Dillon, AK; Han, YG; Huillard, E; Sun, T; Ligon, AH; Qian, Y; Ma, Q; Alvarez-Buylla, A; McMahon, AP; Rowitch, DH; Ligon, KL,期刊：Cancer Cell, 页码：123-134 , 文章类型： Article，,卷期：2008年14-2] Whether the brain tumor medulloblastoma originates from stem cells or restricted progenitor cells is unclear. To investigate this, we activated oncogenic Hedgehog (Hh) signaling in multipotent and lineage-restricted cent... Medulloblastoma can be initiated by deletion of patched in lineage-restricted progenitors or stem cells [作者：Yang, ZJ; Ellis, T; Markant, SL; Read, TA; Kessler, JD; Bourboulas, M; Schuller, U; Machold, R; Fishell, G; Rowitch, DH; Wainwright, BJ; Wechsler-Reya, RJ,期刊：Cancer Cell, 页码：135-145 , 文章类型： Article，,卷期：2008年14-2] Medulloblastoma is the most common malignant brain tumor in children, but the cells from which it arises remain unclear. Here we examine the origin of medulloblastoma resulting from mutations in the Sonic hedgehog (Shh) ... A prostatic intraepithelial neoplasia-dependent p27(Kip1) checkpoint induces senescence and inhibits cell proliferation and cancer progression [作者：Majumder, PK; Grisanzio, C; O'Connell, F; Barry, M; Brito, JM; Xu, Q; Guney, I; Berger, R; Herman, P; Bikoff, R; Fedele, G; Baek, WK; Wang, S; Ellwood-Yen, K; Wu, H; Sawyers, CL; Signoretti, S; Hahn, WC; Loda, M; Sellers, WR,期刊：Cancer Cell, 页码：146-155 , 文章类型： Article，,卷期：2008年14-2] Transgenic expression of activated AKT1 in the murine prostate induces prostatic intraepithelial neoplasia (PIN) that does not progress to invasive prostate cancer (CaP). In luminal epithelial cells of Akt-driven PIN, we... Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis [作者：Sakurai, T; He, G; Matsuzawa, A; Yu, GY; Maeda, S; Hardiman, G; Karin, M,期刊：Cancer Cell, 页码：156-165 , 文章类型： Article，,卷期：2008年14-2] Hepatocyte 1 kappa B kinase beta (IKK beta) inhibits hepatocarcinogenesis by suppressing accumulation of reactive oxygen species (ROS) and liver damage, whereas JNK1 activation promotes ROS accumulation, liver damage, an... DNA replication stalling attenuates tyrosine kinase signaling to suppress S phase progression [作者：Shields, BJ; Hauser, C; Bukczynska, PE; Court, NW; Tiganis, T,期刊：Cancer Cell, 页码：166-179 , 文章类型： Article，,卷期：2008年14-2] Here we report that T cell protein tyrosine phosphatase (TCPTP)-dependent and -independent pathways attenuate the JAK and Src protein tyrosine kinases (PTKs) and STAT3 phosphorylation to suppress cyclin D1 expression and... Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha [作者：Zunder, ER; Knight, ZA; Houseman, BT; Apsel, B; Shokat, KM,期刊：Cancer Cell, 页码：180-192 , 文章类型： Article，,卷期：2008年14-2] p110 alpha (PIK3CA) is the most frequently mutated kinase in human cancer, and numerous drugs targeting this kinase are currently in preclinical development or early-stage clinical trials. Clinical resistance to protein ... Beyond genetics: Surprising determinants of cell fate in antitumor drugs [作者：Holland, AJ; Cleveland, DW,期刊：Cancer Cell, 页码：103-105 , 文章类型： Editorial Material，,卷期：2008年14-2] In this issue of Cancer Cell, Gascoigne and Taylor (2008) report their findings of following 10,000 single cells incubated with three classes of antimitotic drugs, including paclitaxel (taxol). This extensive analysis re... Even cancers want commitment: Lineage identity and medulloblastoma formation [作者：Eberhart, CG,期刊：Cancer Cell, 页码：105-107 , 文章类型： Editorial Material，,卷期：2008年14-2] In this issue of Cancer Cell, Yang et al. (2008) and Schuller et al. (2008) show that Hedgehog activation in either multipotent neural stem cells or developmentally restricted progenitors causes only medulloblastomas to ... Drug-resistant phosphatidylinositol 3-kinase: Guidance for the preemptive strike [作者：Vogt, PK,期刊：Cancer Cell, 页码：107-108 , 文章类型： Editorial Material，,卷期：2008年14-2] In this issue of Cancer Cell, Zunder et al. (2008) describe surprising findings from investigating inhibitor-resistant mutations in the affinity pocket of p110 alpha of phosphatidylinositol 3-kinase (PI3K). Information o... The ever-lengthening arm of p53 [作者：Evan, GI,期刊：Cancer Cell, 页码：108-110 , 文章类型： Editorial Material，,卷期：2008年14-2] p53 is a pivotal bulwark against cancer, but exactly how it suppresses tumors remains elusive, in part because it modulates such diverse biological processes via so many downstream pathways. In a recent issue of Cell, Go...