The ever-lengthening arm of p53

[摘要]：p53 is a pivotal bulwark against cancer, but exactly how it suppresses tumors remains elusive, in part because it modulates such diverse biological processes via so many downstream pathways. In a recent issue of Cell, Godar et al. (2008) now identify another string to p53's anticancer bow-repression of the CD44 cell-surface glycoproteins that coordinate many attributes of tumor progression.

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