- Finding a Target for Resveratrol
[作者：Tennen, RI; Michishita-Kioi, E; Chua, KF,期刊：Cell, 页码：387-389 , 文章类型： Article，,卷期：2012年148-3]
- Despite resveratrol's well-documented health benefits, its mechanism of action remains controversial. In particular, the direct molecular target of resveratrol has been elusive. Park et al. now show that resveratrol dire...
- Innate Immunity to TB: A Druggable Balancing Act
[作者：Lalvani, A; Behr, MA; Sridhar, S,期刊：Cell, 页码：389-391 , 文章类型： Article，,卷期：2012年148-3]
- Tobin and colleagues show that both inhibition and excessive production of the inflammatory mediator TNFa impact the pathogenesis of tuberculosis (TB) and the response to therapy. Identifying a critical role for the gene...
- Immune Cells Exploit a Neural Circuit to Enter the CNS
[作者：Tracey, KJ,期刊：Cell, 页码：392-394 , 文章类型： Article，,卷期：2012年148-3]
- Multiple sclerosis (MS) is associated with the appearance of autoreactive T cells in the central nervous system. Using a mouse model of MS, Arima et al. now show that this attack begins at a specific spinal cord location...
- A New Histone at the Centromere?
[作者：Foltz, DR; Stukenberg, PT,期刊：Cell, 页码：394-396 , 文章类型： Article，,卷期：2012年148-3]
- The centromere is a classic system to study epigenetic specification, and most research has focused on a specialized histone variant, CENP-A, that is required for kinetochore assembly. Now Nishino et al. reveal a new lev...
- FGF21 and the Second Coming of PPAR gamma
[作者：Qiang, L; Accili, D,期刊：Cell, 页码：397-398 , 文章类型： Article，,卷期：2012年148-3]
- Peptide hormone fibroblast growth factor-21 (FGF21) has insulin-mimetic properties. Dutchak et al. now suggest that FGF21 also acts in an autocrine fashion in adipocytes and is required to mediate effects of the PPAR gam...
- Hypoxia-Inducible Factors in Physiology and Medicine
[作者：Semenza, GL,期刊：Cell, 页码：399-408 , 文章类型： Review，,卷期：2012年148-3]
- Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) are transcriptional activators that function as ...
- The Genetic Basis for Cancer Treatment Decisions
[作者：Dancey, JE; Bedard, PL; Onetto, N; Hudson, TJ,期刊：Cell, 页码：409-420 , 文章类型： Review，,卷期：2012年148-3]
- Personalized cancer medicine is based on increased knowledge of the cancer mutation repertoire and availability of agents that target altered genes or pathways. Given advances in cancer genetics, technology, and therapeu...
- Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases
[作者：Park, SJ; Ahmad, F; Philp, A; Baar, K; Williams, T; Luo, HB; Ke, HM; Rehmann, H; Taussig, R; Brown, AL; Kim, MK; Beaven, MA; Burgin, AB; Manganiello, V; Chung, JH,期刊：Cell, 页码：421-433 , 文章类型： Article，,卷期：2012年148-3]
- Resveratrol, a polyphenol in red wine, has been reported as a calorie restriction mimetic with potential antiaging and antidiabetogenic properties. It is widely consumed as a nutritional supplement, but its mechanism of ...
- Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections
[作者：Tobin, DM; Roca, FJ; Oh, SF; McFarland, R; Vickery, TW; Ray, JP; Ko, DC; Zou, YX; Bang, ND; Chau, TTH; Vary, JC; Hawn, TR; Dunstan, SJ; Farrar, JJ; Thwaites, GE; King, MC; Serhan, CN; Ramakrishnan, L,期刊：Cell, 页码：434-446 , 文章类型： Article，,卷期：2012年148-3]
- Susceptibility to tuberculosis is historically ascribed to an inadequate immune response that fails to control infecting mycobacteria. In zebrafish, we find that susceptibility to Mycobacterium marinum can result from ei...
- Regional Neural Activation Defines a Gateway for Autoreactive T Cells to Cross the Blood-Brain Barrier
[作者：Arima, Y; Harada, M; Kamimura, D; Park, JH; Kawano, F; Yull, FE; Kawamoto, T; Iwakura, Y; Betz, UAK; Marquez, G; Blackwell, TS; Ohira, Y; Hirano, T; Murakami, M,期刊：Cell, 页码：447-457 , 文章类型： Article，,卷期：2012年148-3]
- Although it is believed that neural activation can affect immune responses, very little is known about the neuroimmune interactions involved, especially the regulators of immune traffic across the blood-brain barrier whi...
- Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome
[作者：Sexton, T; Yaffe, E; Kenigsberg, E; Bantignies, F; Leblanc, B; Hoichman, M; Parrinello, H; Tanay, A; Cavalli, G,期刊：Cell, 页码：458-472 , 文章类型： Article，,卷期：2012年148-3]
- Chromosomes are the physical realization of genetic information and thus form the basis for its readout and propagation. Here we present a high-resolution chromosomal contact map derived from a modified genome-wide chrom...
- A Transcription Factor Collective Defines Cardiac Cell Fate and Reflects Lineage History
[作者：Junion, G; Spivakov, M; Girardot, C; Braun, M; Gustafson, EH; Birney, E; Furlong, EEM,期刊：Cell, 页码：473-486 , 文章类型： Article，,卷期：2012年148-3]
- Cell fate decisions are driven through the integration of inductive signals and tissue-specific transcription factors (TFs), although the details on how this information converges in cis remain unclear. Here, we demonstr...
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