- p63 and Epithelial Metaplasia: A Gutsy Choice
[作者：Lefort, K; Dotto, GP,期刊：Cell, 页码：1003-1005 , 文章类型： Editorial Material，,卷期：2011年145-7]
- Barrett's esophagus is an epithelial metaplasia associated with an increased risk for cancer, but its underlying mechanisms have been debated. Now Wang et al. (2011) suggest an intriguing explanation for this puzzle: a p...
- Stress Signaling Etches Heritable Marks on Chromatin
[作者：Siomi, H; Siomi, MC,期刊：Cell, 页码：1005-1007 , 文章类型： Editorial Material，,卷期：2011年145-7]
- Transgenerational inheritance of epigenetic states allows organisms to pass on adaptive responses to the environment to their offspring. Seong et al. (2011) now reveal how stress- induced signaling through dATF-2 disrupt...
- The Pessimist's and Optimist's Views of Adult Neurogenesis
[作者：Kempermann, G,期刊：Cell, 页码：1009-1011 , 文章类型： Editorial Material，,卷期：2011年145-7]
- The reports by Bonaguidi et al. (in this issue of Cell) and Encinas et al. (in Cell Stem Cell) come to differing conclusions about whether and how the proliferation of radial glia-like stem cells of the adult hippocampus...
- Life at the Leading Edge
[作者：Ridley, AJ,期刊：Cell, 页码：1012-1022 , 文章类型： Review，,卷期：2011年145-7]
- Cell migration requires sustained forward movement of the plasma membrane at the cell's front or "leading edge.'' To date, researchers have uncovered four distinct ways of extending the membrane at the leading edge. In l...
- Residual Embryonic Cells as Precursors of a Barrett's-like Metaplasia
[作者：Wang, X; Ouyang, H; Yamamoto, Y; Kumar, PA; Wei, TS; Dagher, R; Vincent, M; Lu, X; Bellizzi, AM; Ho, KY; Crum, CP; Xian, W; McKeon, F,期刊：Cell, 页码：1023-1035 , 文章类型： Article，,卷期：2011年145-7]
- Barrett's esophagus is an intestine-like metaplasia and precursor of esophageal adenocarcinoma. Triggered by gastroesophageal reflux disease, the origin of this metaplasia remains unknown. p63-deficient mice, which lack ...
- Exome Sequencing of Ion Channel Genes Reveals Complex Profiles Confounding Personal Risk Assessment in Epilepsy
[作者：Klassen, T; Davis, C; Goldman, A; Burgess, D; Chen, T; Wheeler, D; McPherson, J; Bourquin, T; Lewis, L; Villasana, D; Morgan, M; Muzny, D; Gibbs, R; Noebels, J,期刊：Cell, 页码：1036-1048 , 文章类型： Article，,卷期：2011年145-7]
- Ion channel mutations are an important cause of rare Mendelian disorders affecting brain, heart, and other tissues. We performed parallel exome sequencing of 237 channel genes in a well-characterized human sample, compar...
- Inheritance of Stress-Induced, ATF-2-Dependent Epigenetic Change
[作者：Seong, KH; Li, D; Shimizu, H; Nakamura, R; Ishii, S,期刊：Cell, 页码：1049-1061 , 文章类型： Article，,卷期：2011年145-7]
- Atf1, the fission yeast homolog of activation transcription factor-2 (ATF-2), contributes to heterochromatin formation. However, the role of ATF-2 in chromatin assembly in higher organisms remains unknown. This study rev...
- Insights into the Micromechanical Properties of the Metaphase Spindle
[作者：Shimamoto, Y; Maeda, YT; Ishiwata, S; Libchaber, AJ; Kapoor, TM,期刊：Cell, 页码：1062-1074 , 文章类型： Article，,卷期：2011年145-7]
- The microtubule-based metaphase spindle is subjected to forces that act in diverse orientations and over a wide range of timescales. Currently, we cannot explain how this dynamic structure generates and responds to force...
- An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme
[作者：Ceccarelli, DF; Tang, XJ; Pelletier, B; Orlicky, S; Xie, WL; Plantevin, V; Neculai, D; Chou, YC; Ogunjimi, A; Al-Hakim, A; Varelas, X; Koszela, J; Wasney, GA; Vedadi, M; Dhe-Paganon, S; Cox, S; Xu, SC; Lopez-Girona, A; Mercurio, F; Wrana, J; Durocher, D; ,期刊：Cell, 页码：1075-1087 , 文章类型： Article，,卷期：2011年145-7]
- In the ubiquitin-proteasome system (UPS), E2 enzymes mediate the conjugation of ubiquitin to substrates and thereby control protein stability and interactions. The E2 enzyme hCdc34 catalyzes the ubiquitination of hundred...
- The INAD Scaffold Is a Dynamic, Redox-Regulated Modulator of Signaling in the Drosophila Eye
[作者：Liu, W; Wen, WY; Wei, ZY; Yu, J; Ye, F; Liu, CH; Hardie, RC; Zhang, MJ,期刊：Cell, 页码：1088-1101 , 文章类型： Article，,卷期：2011年145-7]
- INAD is a scaffolding protein that regulates signaling in Drosophila photoreceptors. One of its PDZ domains, PDZ5, cycles between reduced and oxidized forms in response to light, but it is unclear how light affects its r...
- Golgi Export of the Kir2.1 Channel Is Driven by a Trafficking Signal Located within Its Tertiary Structure
[作者：Ma, DH; Taneja, TK; Hagen, BM; Kim, BY; Ortega, B; Lederer, WJ; Welling, PA,期刊：Cell, 页码：1102-1115 , 文章类型： Article，,卷期：2011年145-7]
- Mechanisms that are responsible for sorting newly synthesized proteins for traffic to the cell surface from the Golgi are poorly understood. Here, we show that the potassium channel Kir2.1, mutations in which are associa...
|