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An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme

作者	Ceccarelli, DF; Tang, XJ; Pelletier, B; Orlicky, S; Xie, WL; Plantevin, V; Neculai, D; Chou, YC; Ogunjimi, A; Al-Hakim, A; Varelas, X; Koszela, J; Wasney, GA; Vedadi, M; Dhe-Paganon, S; Cox, S; Xu, SC; Lopez-Girona, A; Mercurio, F; Wrana, J; Durocher, D;

选自	期刊 Cell; 卷期 2011年145-7; 页码 1075-1087

关联知识点

[摘要]：In the ubiquitin-proteasome system (UPS), E2 enzymes mediate the conjugation of ubiquitin to substrates and thereby control protein stability and interactions. The E2 enzyme hCdc34 catalyzes the ubiquitination of hundreds of proteins in conjunction with t
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