Genetic and biological studies provide evidence that the deposition of amyloid-beta peptide contributes to the etiology of Alzheimer's disease (AD). Amyloid-beta peptides are generated from amyloid-beta precursor prot...
The basic claims of this application involve methods that use a polymer to deliver therapeutic molecules in a targeted fashion using a polymeric carrier, drug and a biologically degradable linker. The release of thera...
Bifunctional aromatic compounds that contain both beta(2) agonist and muscarinic antagonist pharmacophores linked by a flexible lipophilic spacer are claimed. The compounds display nanomolar potency with respect to bo...
Nowadays fixed-dose combinations and me-too drugs are important strategies in the fight against multi-drug resistant microorganisms and other kind of diseases and have been studied by several pharmaceutical companies....
Background: Ghrelin is an endogenous ligand of the growth hormone secretagogue receptor (GHS-R) that functions as a short-term meal initiator and a long-term energy balance regulator. Antagonizing GHS-R could be a met...
Background: The clinical success of the tyrosine kinase inhibitor imatinib (Gleevec; STI-571) in the treatment of several leukemias has emphasized the proof-of-concept that molecularly targeted drug design is a viable...
Background: Tetrapyrrole photosensitisers are the main drugs used in the various photodynamic therapies. They are based on light-induced reactive oxygen species whose lifetimes are very short, limiting their diffusion...
Background: Modulation of synaptic functions holds great potential as therapeutic strategies to manage neurodegenerative disorders in which cognitive functions are usually impaired as a core symptom of the disorders. ...
Background: Chronic pain conditions, whether inflammatory or neuropathic in origin remain a significant unmet medical need. Existing treatments exhibit insufficient efficacy and also produce dose-limiting side effects...