Pfizer's dual-acting beta(2) agonists/muscarinic M-3 antagonists

[摘要]：

Bifunctional aromatic compounds that contain both beta(2) agonist and muscarinic antagonist pharmacophores linked by a flexible lipophilic spacer are claimed. The compounds display nanomolar potency with respect to both activities and appear designed to provide a long duration of action. The compounds are claimed to be useful in the treatment of both asthma and chronic obstructive pulmonary disease.

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