- Sperm are promiscuous and CatSper is to blame ...
[作者：Barratt, CLR; Publicover, SJ,期刊：EMBO journal, 页码：1624-1626 , 文章类型： Editorial Material，,卷期：2012年31-7]
- A sperm-specific cation channel (CatSper) facilitates the entry of calcium necessary for rapid changes in sperm motility allowing the cell to navigate the hurdles of the female reproductive tract and successfully to loca...
- Protease signalling: the cutting edge
[作者：Turk, B; Turk, D; Turk, V,期刊：EMBO journal, 页码：1630-1643 , 文章类型： Review，,卷期：2012年31-7]
- Protease research has undergone a major expansion in the last decade, largely due to the extremely rapid development of new technologies, such as quantitative proteomics and in-vivo imaging, as well as an extensive use o...
- Human mitotic chromosomes consist predominantly of irregularly folded nucleosome fibres without a 30-nm chromatin structure
[作者：Nishino, Y; Eltsov, M; Joti, Y; Ito, K; Takata, H; Takahashi, Y; Hihara, S; Frangakis, AS; Imamoto, N; Ishikawa, T; Maeshima, K,期刊：EMBO journal, 页码：1644-1653 , 文章类型： Article，,卷期：2012年31-7]
- How a long strand of genomic DNA is compacted into a mitotic chromosome remains one of the basic questions in biology. The nucleosome fibre, in which DNA is wrapped around core histones, has long been assumed to be folde...
- The CatSper channel: a polymodal chemosensor in human sperm
[作者：Brenker, C; Goodwin, N; Weyand, I; Kashikar, ND; Naruse, M; Krahling, M; Muller, A; Kaupp, UB; Strunker, T,期刊：EMBO journal, 页码：1654-1665 , 文章类型： Article，,卷期：2012年31-7]
- The sperm-specific CatSper channel controls the intracellular Ca2+ concentration ([Ca2+](i)) and, thereby, the swimming behaviour of sperm. In humans, CatSper is directly activated by progesterone and prostaglandins-fema...
- Highly diverse TCR alpha chain repertoire of pre-immune CD8(+) T cells reveals new insights in gene recombination
[作者：Genolet, R; Stevenson, BJ; Farinelli, L; Osteras, M; Luescher, IF,期刊：EMBO journal, 页码：1666-1678 , 文章类型： Article，,卷期：2012年31-7]
- Although the T-cell receptor alpha delta (TCR alpha delta) locus harbours large libraries of variable (TRAV) and junctional (TRAJ) gene segments, according to previous studies the TCR alpha chain repertoire is of limited...
- IAPs limit activation of RIP kinases by TNF receptor 1 during development
[作者：Moulin, M; Anderton, H; Voss, AK; Thomas, T; Wong, WWL; Bankovacki, A; Feltham, R; Chau, D; Cook, WD; Silke, J; Vaux, DL,期刊：EMBO journal, 页码：1679-1691 , 文章类型： Article，,卷期：2012年31-7]
- Inhibitor of apoptosis (IAP) proteins cIAP1, cIAP2, and XIAP (X-linked IAP) regulate apoptosis and cytokine receptor signalling, but their overlapping functions make it difficult to distinguish their individual roles. To...
- Cytoplasmic Arabidopsis AGO7 accumulates in membrane-associated siRNA bodies and is required for ta-siRNA biogenesis
[作者：Jouannet, V; Moreno, AB; Elmayan, T; Vaucheret, H; Crespi, MD; Maizel, A,期刊：EMBO journal, 页码：1704-1713 , 文章类型： Article，,卷期：2012年31-7]
- Formation of trans-acting small interfering RNAs (ta-siRNAs) from the TAS3 precursor is triggered by the AGO7/miR390 complex, which primes TAS3 for conversion into double-stranded RNA by the RNA-dependent RNA polymerase ...
- A pRNA-induced structural rearrangement triggers 6S-1 RNA release from RNA polymerase in Bacillus subtilis
[作者：Beckmann, BM; Hoch, PG; Marz, M; Willkomm, DK; Salas, M; Hartmann, RK,期刊：EMBO journal, 页码：1727-1738 , 文章类型： Article，,卷期：2012年31-7]
- Bacillus subtilis 6S-1 RNA binds to the housekeeping RNA polymerase (sigma(A)-RNAP) and directs transcription of short 'product' RNAs (pRNAs). Here, we demonstrate that once newly synthesized pRNAs form a sufficiently st...
- Epigenetic silencing of myogenic gene program by Myb-binding protein 1a suppresses myogenesis
[作者：Yang, CC; Liu, H; Chen, SL; Wang, TH; Hsieh, CL; Huang, Y; Chen, SJ; Chen, HC; Yung, BYM; Tan, BCM,期刊：EMBO journal, 页码：1739-1751 , 文章类型： Article，,卷期：2012年31-7]
- Skeletal myogenesis involves highly coordinated steps that integrate developmental cues at the chromatin of muscle progenitors. Here, we identify Myb-binding protein 1a (Mybbp1a) as a novel negative regulator of muscle-s...
- miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver
[作者：Okamoto, K; Ishiguro, T; Midorikawa, Y; Ohata, H; Izumiya, M; Tsuchiya, N; Sato, A; Sakai, H; Nakagama, H,期刊：EMBO journal, 页码：1752-1763 , 文章类型： Article，,卷期：2012年31-7]
- Liver metastasis is a major lethal complication associated with colon cancer, and post-intravasation steps of the metastasis are important for its clinical intervention. In order to identify inhibitory microRNAs (miRNAs)...
- Cholesterol loss during glutamate-mediated excitotoxicity
[作者：Sodero, AO; Vriens, J; Ghosh, D; Stegner, D; Brachet, A; Pallotto, M; Sassoe-Pognetto, M; Brouwers, JF; Helms, JB; Nieswandt, B; Voets, T; Dotti, CG,期刊：EMBO journal, 页码：1764-1773 , 文章类型： Article，,卷期：2012年31-7]
- The deregulation of brain cholesterol metabolism is typical in acute neuronal injury (such as stroke, brain trauma and epileptic seizures) and chronic neurodegenerative diseases (Alzheimer's disease). Since both conditio...
- Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteins
[作者：Goody, PR; Heller, K; Oesterlin, LK; Muller, MP; Itzen, A; Goody, RS,期刊：EMBO journal, 页码：1774-1784 , 文章类型： Article，,卷期：2012年31-7]
- The Legionella pneumophila protein AnkX that is injected into infected cells by a Type IV secretion system transfers a phosphocholine group from CDP-choline to a serine in the Rab1 and Rab35 GTPase Switch II regions. We ...
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