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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共14条记录   The Use of 3,5,4 '-Tri-O-acetylresveratrol as a Potential Prodrug for Resveratrol Protects Mice from gamma-Irradiation-Induced Death [作者：KOIDE KAZUNORI; OSMAN SAMI; GARNER AMANDA L; SONG FENGLING; DIXON TRACY; GREENBERGER JOEL S; EPPERLY MICHAEL W,期刊：ACS Medicinal Chemistry Letters, 页码：270-274 , 文章类型： Article，,卷期：2011年2-4] Currently, no drugs are available to protect humans from gamma-irradiation-induced death. Because reactive oxygen species are produced upon exposure to gamma-irradiation and directly responsible for the resulting death, ... Membrane-Targeted Nanotherapy with Hybrid Liposomes for Tumor Cells Leading to Apoptosis [作者：KOMIZU YUJI; NAKATA SAYURI; GOTO KOICHI; MATSUMOTO YOKO; UEOKA RYUICHI,期刊：ACS Medicinal Chemistry Letters, 页码：275-279 , 文章类型： Article，,卷期：2011年2-4] Hybrid liposomes are nanosized liposomal particles and can be prepared by sonication of vesicular and micellar molecules in a buffer solution. In this study, we obtained the first successful experiment resulting in a goo... Hydrophobic Binding Hot Spots of Bcl-xL Protein-Protein Interfaces by Cosolvent Molecular Dynamics Simulation [作者：YANG CHAOYIE; WANG SHAOMENG,期刊：ACS Medicinal Chemistry Letters, 页码：280-284 , 文章类型： Article，,卷期：2011年2-4] Identifying binding hot spots in protein protein interfaces is important for understanding the binding specificity and for the design of nonpeptide, small molecule inhibitors. Molecular dynamics: simulation in the isopro... PET Imaging and Biodistribution of Silicon Quantum Dots in Mice [作者：TU CHUQIAO; MA XUCHU; HOUSE ADRIAN; KAUZLARICH SUSAN M; LOUIE ANGELIQUE Y,期刊：ACS Medicinal Chemistry Letters, 页码：285-288 , 文章类型： Article，,卷期：2011年2-4] Investigation of nanomaterial disposition and fate in the body is critical before such material can be translated into clinical application. Herein a new macrocyclic ligand Cu-64(2+) complex was synthesized and used to l... N-Benzyl-3-sulfonamidopyrrolidines Are a New Class of Bacterial DNA Gyrase Inhibitors [作者：FOSS MARIE H; HURLEY KATHERINE A; SORTO NOHEMY A; LACKNER LAURA L; THORNTON KELSEY M; SHAW JARED T; WEIBEL DOUGLAS B,期刊：ACS Medicinal Chemistry Letters, 页码：289-292 , 文章类型： Article，,卷期：2011年2-4] This paper characterizes N-benzyl-3-sulfonamidopyrrolidines (gyramides) as DNA gyrase inhibitors. Gyramide A was previously shown to exhibit antimicrobial activity, which suggested it inhibited bacterial cell division. I... Homology Model Versus X-ray Structure in Receptor-based Drug Design: A Retrospective Analysis with the Dopamine D3 Receptor [作者：LEVOIN NICOLAS; CALMELS THIERRY; KRIEF STEPHANE; DANVY DENIS; BERREBIBERTRAND ISABELLE; LECORNTE JEANNEMARIE; SCHWARTZ JEANCHARLES; CAPET MARC,期刊：ACS Medicinal Chemistry Letters, 页码：293-297 , 文章类型： Article，,卷期：2011年2-4] Structure-based design methods commonly used in medicinal chemistry rely on a three-dimensional representation of the receptor. However, few crystal structures are solved in comparison with the huge number of pharmaceuti... Design, Synthesis, and X-ray Structure of Substituted Bis-tetrahydrofuran (Bis-THF)-Derived Potent HIV-1 Protease Inhibitors [作者：GHOSH ARUN K; MARTYR CUTHBERT D; STEFFEY MELINDA; WANG YUANFANG; AGNISWAMY JOHNSON; AMANO MASAYUKI; WEBER IRENE T; MITSUYA HIROAKI,期刊：ACS Medicinal Chemistry Letters, 页码：298-302 , 文章类型： Article，,卷期：2011年2-4] We investigated substituted bis-THF-derived HIV-1 protease inhibitors in order to enhance liga:nd-binding site interactions in the HIV-1 protease active site. In this context:, we have carried out convenient syntheses of... Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139 [作者：SHI FENG; SHEN JING KANG; CHEN DANQI; FOG KARINA; THIRSTRUP KENNETH; HENTZER MORTEN; KARLSSON JENSJAKOB; MENON VEENA; JONES KENNETH A; SMITH KELLI E; SMITH GARRICK,期刊：ACS Medicinal Chemistry Letters, 页码：303-306 , 文章类型： Article，,卷期：2011年2-4] GPR139 is an orphan G-protein coupled receptor (GPCR) Which is primarily expressed in the central nervous system (CNS). In order to explore the biological function of this receptor, selective tool compounds are required.... Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in Inhibitors of M2 from Influenza A Virus [作者：WANG JUN; MA CHUNLONG; BALANNIK VICTORIA; PINTO LAWRENCE H; LAMB ROBERT A; DEGRADO WILLIAM F,期刊：ACS Medicinal Chemistry Letters, 页码：307-312 , 文章类型： Article，,卷期：2011年2-4] Inhibitors targeting the influenza A virus M2 (A/M2) proton channel have lost their effectiveness due to widespread resistance. As a first step in the development of new inhibitors that address this problem, we have scre... Total Syntheses and Cytotoxicity of (R)- and (S)-Boehmeriasin A [作者：LEIGHTY MATTHEW W; GEORG GUNDA I,期刊：ACS Medicinal Chemistry Letters, 页码：313-315 , 文章类型： Article，,卷期：2011年2-4] Both enantiomers of boehmeriasin A were synthesized in seven steps each using a chiral pool approach. Key steps in the syntheses are a one-flask, two-step protocol to generate the quinolizine core and a C H functionaliza... 3-Alkoxy-1,2-Dioxolanes: Synthesis and Evaluation as Potential Antimalarial Agents [作者：SCHIAFFO CHARLES E; ROTTMAN MATTHIAS; WITTLIN SERGIO; DUSSAULT PATRICK H,期刊：ACS Medicinal Chemistry Letters, 页码：316-319 , 文章类型： Article，,卷期：2011年2-4] A number of 3-alkoxy-1,2-dioxolanes exhibit promising levels of antimalarial activity against Plasmodium falciparum. A new route to the 1,2-dioxolane core is reported based on tandem peroxidation/cyclization of enones. Discovery of a Highly Potent and Selective MEK Inhibitor: GSK1120212 (JTP-74057 DMSO Solvate) [作者：ABE HIROYUKI; KIKUCHI SHINICHI; HAYAKAWA KAZUHIDE; IIDA TETSUYA; NAGAHASHI NOBORU; MAEDA KATSUYA; SAKAMOTO JOHEI; MATSUMOTO NORIAKI; MIURA TOMOYA; MATSUMURA KOJI; SEKI NORIYOSHI; INABA TAKASHI; KAWASAKI HISASHI; YAMAGUCHI TAKAYUKI; KAKEFUDA REINA; NANAYAMA TOYOMICHI; KURACHI HIRONORI; HORI YOSHIKAZU; YOSHIDA TAKAYUKI; KAKEGAWA JUNYA; WATANABE YOSHIHIRO; GILMARTIN AIDAN G; RICHTER MARK C; MOSS KATHERINE G; LAQUERRE SYLVIE G,期刊：ACS Medicinal Chemistry Letters, 页码：320-324 , 文章类型： Article，,卷期：2011年2-4] Inhibition of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) represents a promising strategy for the discovery of a new generation of anticancer chemotherapeutics. Our synthetic effor... C5 '-Alkyl Substitution Effects on Digitoxigenin alpha-L-Glycoside Cancer Cytatoxicity [作者：WANG HUAYU LEO; WU BULAN; ZHANG QI; KANG SANGWOO; ROJANASAKUL YON; ODOHERTY GEORGE A,期刊：ACS Medicinal Chemistry Letters, 页码：259-263 , 文章类型： Article，,卷期：2011年2-4] A highly regio- and stereoselective asymmetric synthesis of various CS'-alkyl side chains of rhamnosyl- and amicetosyl-digitoxigenin analogues has been established via palladium-catalyzed glycosylation with postglycosyla... Synthesis and Evaluation of the alpha-D-/alpha-L-Rhamnosyl and Amicetosyl Digitoxigenin Oligomers as Antitumor Agents [作者：WANG HUAYU LEO; ROJANASAKUL YON; ODOHERTY GEORGE A,期刊：ACS Medicinal Chemistry Letters, 页码：264-269 , 文章类型： Article，,卷期：2011年2-4] A highly regio- and stereoselective asymmetric synthesis of rhamnosyl- and amicetpsyl-digitoxigenin analogues has been established via palladium catalyzed glycosylation followed by big-/tris-dihydroxylation or bis-/tris-...