The Use of 3,5,4 '-Tri-O-acetylresveratrol as a Potential Prodrug for Resveratrol Protects Mice from gamma-Irradiation-Induced Death

[摘要]：Currently, no drugs are available to protect humans from gamma-irradiation-induced death. Because reactive oxygen species are produced upon exposure to gamma-irradiation and directly responsible for the resulting death, we hypothesized that antioxidants found in foodstuffs may provide a safe and potent means of antioxidant-dependent radioprotection. Here, we describe our studies investigating the radioprotective properties of resveratrol and 3,5,4'-tri-O-acetylresveratrol. Each of these natural antioxidants was found to protect live cells after gamma-irradiation. In mice, the use of 3,5,4'-tri-O-acetylresveratrol with Cremophor EL was particularly effective, indicating that this natural antioxidant may be a leading candidate for radioprotective drug development.

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