- Sirolimus As Primary Immunosuppressant Reduces Left Ventricular Mass and Improves Diastolic Function of the Cardiac Allograft
[作者:Raichlin, E; Chandrasekaran, K; Kremers, WK; Frantz, RP; Clavell, AL; Pereira, NL; Rodeheffer, RJ; Daly, RC; McGregor, CGA; Edwards, BS; Kushwaha, SS,期刊:Transplantation, 页码:1395-1400 , 文章类型: Article,,卷期:2008年86-10]
- Background. Left ventricular hypertrophy (LVH) and diastolic dysfunction occur after cardiac transplantation. We investigated sirolimus (SRL) as primary immunosuppression for the attenuation of LVH and diastolic dysfunct...
- Blood Group ABO Antigen Expression in Human Embryonic Stem Cells and in Differentiated Hepatocyte- and Cardiomyocyte-Like Cells
[作者:Molne, J; Bjorquist, P; Andersson, K; Diswall, M; Jeppsson, A; Strokan, V; Rydberg, L; Breimer, ME,期刊:Transplantation, 页码:1407-1413 , 文章类型: Article,,卷期:2008年86-10]
- Background. The use of stein cells in regenerative medicine and transplantation may require grafting of cells that will challenge the recipient's immune system. Our knowledge of tissue antigen expression in human embryon...
- Effects of Selective Phosphodiesterase-5-Inhibition on Myocardial Contractility and Reperfusion Injury After Heart Transplantation
[作者:Loganathan, S; Radovits, T; Hirschberg, K; Korkmaz, S; Barnucz, E; Karck, M; Szabo, G,期刊:Transplantation, 页码:1414-1418 , 文章类型: Article,,卷期:2008年86-10]
- Recently, the infarct reducing and cardioprotective effects of phosphodiesterase-5-inhibitors were described. In this Study, we investigated these effects on ischemia/reperfusion injury in a rat model of heart transplant...
- Upregulation of Molecules Associated With T-Regulatory Function by Thymoglobulin Pretreatment of Human CD4(+) Cells
[作者:Liu, ZD; Fang, YS; Wang, XP; Wang, P; Yun, P; Xu, H,期刊:Transplantation, 页码:1419-1426 , 文章类型: Article,,卷期:2008年86-10]
- Background. This study evaluated the immunologic effects of thymoglobulin in modulating human CD4(+) cells.Methods. Human CD4+ cells were purified from peripheral blood mononuclear cells by negative selection method. CD4...
- Selective Depletion of Alloreactive T Lymphocytes Using Patient-Derived Nonhematopoietic Stimulator Cells in Allograft Engineering
[作者:Nonn, M; Herr, W; Khan, S; Todorova, M; Link, I; Thies, J; Distler, E; Kaltwasser, M; Hoffmann, J; Huber, C; Hartwig, UF,期刊:Transplantation, 页码:1427-1435 , 文章类型: Article,,卷期:2008年86-10]
- Background. Selective depletion of alloreactive T cells in vitro results in efficient graft-versus-host disease prophylaxis in allogeneic hematopoietic stem-cell transplantation, but it is accompanied by increased recurr...
- Inducible Costimulator Blockade Prolongs Airway Luminal Patency in a Mouse Model of Obliterative Bronchiolitis
[作者:KleinJan, A; Willart, MAM; Kuipers, H; Coyle, AJ; Hoogsteden, HC; Lambrecht, BN,期刊:Transplantation, 页码:1436-1444 , 文章类型: Article,,卷期:2008年86-10]
- Background. In human lung transplantation, chronic rejection is accompanied by obliterative bronchiolitis (013), a fibrosing inflammatory condition that leads to occlusion of the bronchial lumen and graft failure. The pa...
- Posttransplant Ischemia-Reperfusion Injury In Transplanted Heart Is Prevented By A Minibody to the Fifth Component of Complement
[作者:Ferraresso, M; Macor, P; Valente, M; Della Barbera, M; D'Amelio, F; Borghi, O; Raschi, E; Durigutto, P; Meroni, P; Tedesco, F,期刊:Transplantation, 页码:1445-1451 , 文章类型: Article,,卷期:2008年86-10]
- Background. Complement activation has been implicated in the development of posttransplant ischemia-reperfusion (I/R) which is responsible for the delayed function of 20% to 30% of grafts. C5a and the terminal complement...
- Pancreatic Islets Induce CD4(+)CD25(-Foxp3+) T-Cell Regulated Tolerance to HY-Mismatched Skin Grafts
[作者:Yoon, IH; Choi, SE; Kim, YH; Yang, SH; Park, JH; Park, CS; Kim, Y; Kim, JS; Kim, SJ; Simpson, E; Park, CG,期刊:Transplantation, 页码:1352-1360 , 文章类型: Article,,卷期:2008年86-10]
- Background. The ability to induce and maintain antigen-specific immunologic tolerance is the ultimate goal in allotransplantation. Here, we report that the transplantation of unmanipulated murine pancreatic islets across...
- The Role of Macrophage Migration Inhibitory Factor in Mouse Islet Transplantation
[作者:Toso, C; Serre-Beinier, V; Emamaullee, J; Merani, S; Armanet, M; Wojtusciszyn, A; Bosco, D; Calandra, T; Roger, T; Morel, P; Shapiro, AMJ; Berney, T,期刊:Transplantation, 页码:1361-1369 , 文章类型: Article,,卷期:2008年86-10]
- Background. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine produced by many tissues including pancreatic beta-cells.Methods. This study investigates the impact of MIF on islet transplantation ...
- FoxP3 in Peripheral Blood Is Associated With Operational Tolerance in Liver Transplant Patients During Immunosuppression Withdrawal
[作者:Pons, JA; Revilla-Nuin, B; Baroja-Mazo, A; Ramirez, P; Martinez-Alarcon, L; Sanchez-Bueno, F; Robles, R; Rios, A; Aparicio, P; Parrilla, P,期刊:Transplantation, 页码:1370-1378 , 文章类型: Article,,卷期:2008年86-10]
- Background. Human liver allografts do sometimes Survive in a recipient after withdrawal of immunosuppression (IS), commonly referred to as "operational tolerance. "Preliminary clinical data have suggested an increase in ...
- Reduced Elimination of Cyclosporine A in Elderly (> 65 Years) Kidney Transplant Recipients
[作者:Falck, P; Asberg, A; Byberg, KT; Bremer, S; Bergan, S; Reubsaet, JLE; Midtvedt, K,期刊:Transplantation, 页码:1379-1383 , 文章类型: Article,,卷期:2008年86-10]
- Background. Physiologic functions that may affect pharmacokinetics of drugs are altered in elderly patients. The current study was performed to elucidate the effect of age on cyclosporine A (CsA) pharmacokinetics in rena...
- Pulmonary Hypertension Is Associated With Reduced Patient Survival After Kidney Transplantation
[作者:Issa, N; Krowka, MJ; Griffin, MD; Hickson, LJ; Stegall, MD; Cosio, FG,期刊:Transplantation, 页码:1384-1388 , 文章类型: Article,,卷期:2008年86-10]
- Introduction. Pulmonary hypertension (PH) is common in patients on dialysis where it is associated with reduced Survival. The possible association between PH and kidney transplant recipient survival has not been previous...
- Quantitative Detection of Epstein-Barr Virus in Bronchoalveolar Lavage From Transplant and Nontransplant Patients
[作者:Costa, C; Elia, M; Astegiano, S; Sidoti, F; Terlizzi, ME; Solidoro, P; Botto, S; Libertucci, D; Bergallo, M; Cavallo, R,期刊:Transplantation, 页码:1389-1394 , 文章类型: Article,,卷期:2008年86-10]
- Background. The lower respiratory tract is a latency site of Epstein-Barr virus (EBV); however, its pathogenic role is poorly known, particularly in transplant patients. The aim of this Study was to evaluate the prevalen...
- Suppressive Efficacy and Proliferative Capacity of Human Regulatory T Cells in Allogeneic and Xenogeneic Responses
[作者:Lin, YJ; Hara, H; Tai, HC; Long, C; Tokita, D; Yeh, P; Ayares, D; Morelli, AE; Cooper, DKC,期刊:Transplantation, 页码:1452-1462 , 文章类型: Article,,卷期:2008年86-10]
- Background. An understanding of the mechanisms that suppress the human anti-pig cellular response is key for xenotransplantation. We have compared the ability of human regulatory T cells (Tregs) to suppress xenogeneic an...
- Perfusion of Renal Allografts With Verapamil Improves Graft Function
[作者:Nguan, CY; Sener, A; Karnik, V; Caumartin, Y; House, AA; McAlister, VC; Luke, PPW,期刊:Transplantation, 页码:1463-1467 , 文章类型: Article,,卷期:2008年86-10]
- The effect of adding a calcium channel antagonist to kidney allograft perfusate solution was assessed. All renal transplants in which both kidneys from the same donor used for transplantation were studied between Novembe...
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