- RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channels
[作者：Decher, N; Streit, AK; Rapedius, M; Netter, MF; Marzian, S; Ehling, P; Schlichthorl, G; Craan, T; Renigunta, V; Kohler, A; Dodel, RC; Navarro-Polanco, RA; Preisig-Muller, R; Klebe, G; Budde, T; Baukrowitz, T; Daut, J,期刊：EMBO journal, 页码：2101-2113 , 文章类型： Article，,卷期：2010年29-13]
- The time course of inactivation of voltage-activated potassium (Kv) channels is an important determinant of the firing rate of neurons. In many Kv channels highly unsaturated lipids as arachidonic acid, docosahexaenoic a...
- Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt
[作者：Mukai, A; Yamamoto-Hino, M; Awano, W; Watanabe, W; Komada, M; Goto, S,期刊：EMBO journal, 页码：2114-2125 , 文章类型： Article，,卷期：2010年29-13]
- Wingless (Wg)/Wnt has been proposed to exert various functions as a morphogen depending on the levels of its signalling. Therefore, not just the concentration of Wg/Wnt, but also the responsiveness of Wg/Wnt-target cells...
- Topoisomerase I regulates open chromatin and controls gene expression in vivo
[作者：Durand-Dubief, M; Persson, J; Norman, U; Hartsuiker, E; Ekwall, K,期刊：EMBO journal, 页码：2126-2134 , 文章类型： Article，,卷期：2010年29-13]
- DNA topoisomerases regulate the topological state of the DNA double helix and are key enzymes in the processes of DNA replication, transcription and genome stability. Using the fission yeast model Schizosaccharomyces pom...
- The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats
[作者：Guetg, C; Lienemann, P; Sirri, V; Grummt, I; Hernandez-Verdun, D; Hottiger, MO; Fussenegger, M; Santoro, R,期刊：EMBO journal, 页码：2135-2146 , 文章类型： Article，,卷期：2010年29-13]
- Maintenance of specific heterochromatic domains is crucial for genome stability. In eukaryotic cells, a fraction of the tandem-repeated ribosomal RNA (rRNA) genes is organized in the heterochromatic structures. The princ...
- Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo
[作者：Wei, GH; Badis, G; Berger, MF; Kivioja, T; Palin, K; Enge, M; Bonke, M; Jolma, A; Varjosalo, M; Gehrke, AR; Yan, JA; Talukder, S; Turunen, M; Taipale, M; Stunnenberg, HG; Ukkonen, E; Hughes, TR; Bulyk, ML; Taipale, J,期刊：EMBO journal, 页码：2147-2160 , 文章类型： Article，,卷期：2010年29-13]
- Members of the large ETS family of transcription factors (TFs) have highly similar DNA-binding domains (DBDs)-yet they have diverse functions and activities in physiology and oncogenesis. Some differences in DNA-binding ...
- Stoichiometry of a regulatory splicing complex revealed by single-molecule analyses
[作者：Cherny, D; Gooding, C; Eperon, GE; Coelho, MB; Bagshaw, CR; Smith, CWJ; Eperon, IC,期刊：EMBO journal, 页码：2161-2172 , 文章类型： Article，,卷期：2010年29-13]
- Splicing is regulated by complex interactions of numerous RNA-binding proteins. The molecular mechanisms involved remain elusive, in large part because of ignorance regarding the numbers of proteins in regulatory complex...
- Importance of polyadenylation in the selective elimination of meiotic mRNAs in growing S. pombe cells
[作者：Yamanaka, S; Yamashita, A; Harigaya, Y; Iwata, R; Yamamoto, M,期刊：EMBO journal, 页码：2173-2181 , 文章类型： Article，,卷期：2010年29-13]
- A number of meiosis-specific mRNAs are initially weakly transcribed, but then selectively removed during fission yeast mitotic growth. These mRNAs harbour a region termed DSR (determinant of selective removal), which is ...
- Prp43p contains a processive helicase structural architecture with a specific regulatory domain
[作者：Walbott, H; Mouffok, S; Capeyrou, R; Lebaron, S; Humbert, O; van Tilbeurgh, H; Henry, Y; Leulliot, N,期刊：EMBO journal, 页码：2194-2204 , 文章类型： Article，,卷期：2010年29-13]
- The DEAH/RNA helicase A (RHA) helicase family comprises proteins involved in splicing, ribosome biogenesis and transcription regulation. We report the structure of yeast Prp43p, a DEAH/RHA helicase remarkable in that it ...
- The crystal structure of Mtr4 reveals a novel arch domain required for rRNA processing
[作者：Jackson, RN; Klauer, AA; Hintze, BJ; Robinson, H; van Hoof, A; Johnson, SJ,期刊：EMBO journal, 页码：2205-2216 , 文章类型： Article，,卷期：2010年29-13]
The essential RNA helicase, Mtr4, performs a critical role in RNA processing and degradation as an activator of the nuclear exosome. The molecular basis for this vital function is not understood and detailed analysis ...
- A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants
[作者：Tang, WK; Li, DY; Li, CC; Esser, L; Dai, RM; Guo, LA; Xia, D,期刊：EMBO journal, 页码：2217-2229 , 文章类型： Article，,卷期：2010年29-13]
Mutations in p97, a major cytosolic AAA (ATPases associated with a variety of cellular activities) chaperone, cause inclusion body myopathy associated with Paget's disease of the bone and frontotemporal dementia (IBMP...
- SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair
[作者：Lam, YC; Akhter, S; Gu, PL; Ye, J; Poulet, A; Giraud-Panis, MJ; Bailey, SM; Gilson, E; Legerski, RJ; Chang, S,期刊：EMBO journal, 页码：2230-2241 , 文章类型： Article，,卷期：2010年29-13]
- Progressive telomere attrition or deficiency of the protective shelterin complex elicits a DNA damage response as a result of a cell's inability to distinguish dysfunctional telomeric ends from DNA double-strand breaks. ...
- TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells
[作者：Mittal, D; Saccheri, F; Venereau, E; Pusterla, T; Bianchi, ME; Rescigno, M,期刊：EMBO journal, 页码：2242-2252 , 文章类型： Article，,卷期：2010年29-13]
- Skin cancers are the most commonly diagnosed cancers. Understanding what are the factors contributing to skin tumour development can be instrumental to identify preventive therapies. The myeloid differentiation primary r...
- The NoRC complex mediates heterochromatin formation and stability of silent rRNA genes and centromeric repeats (vol 29, pg 2135, 2010)
[作者：Guetg, C; Lienemann, P; Sirri, V; Grummt, I; Hernandez-Verdun, D; Hottiger, MO; Fussenegger, M; Santoro, R,期刊：EMBO journal, 页码：2253-2253 , 文章类型： Correction，,卷期：2010年29-13]
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