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[摘要]：Wnt/beta-catenin signalling is initiated by binding of secreted Wnt ligands to Frizzled and LRP5/6/Arrow co-receptors. A new study in this issue of The EMBO Journal provides compelling evidence that the level of cell surface Frizzled is controlled by a cycle of mono-ubiquitylation-deubiquitylation, the latter being mediated by the deubiquitylating enzyme UBPY/USP8. The amount of Frizzled on the plasma membrane appears to be a major rate-limiting factor in determining a cell's Wnt responsiveness. |
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