- An ER-resident membrane protein complex regulates nicotinic acetylcholine receptor subunit composition at the synapse
[作者：Almedom, RB; Liewald, JF; Hernando, G; Schultheis, C; Rayes, D; Pan, J; Schedletzky, T; Hutter, H; Bouzat, C; Gottschalk, A,期刊：EMBO journal, 页码：2636-2649 , 文章类型： Article，,卷期：2009年28-17]
- Nicotinic acetylcholine receptors (nAChRs) are homo- or heteropentameric ligand-gated ion channels mediating excitatory neurotransmission and muscle activation. Regulation of nAChR subunit assembly and transfer of correc...
- Distinct donor and acceptor specificities of Trypanosoma brucei oligosaccharyltransferases
[作者：Izquierdo, L; Schulz, BL; Rodrigues, JA; Guther, MLS; Procter, JB; Barton, GJ; Aebi, M; Ferguson, MAJ,期刊：EMBO journal, 页码：2650-2661 , 文章类型： Article，,卷期：2009年28-17]
- Asparagine-linked glycosylation is catalysed by oligosaccharyltransferase (OTase). In Trypanosoma brucei OTase activity is catalysed by single-subunit enzymes encoded by three paralogous genes of which TbSTT3B and TbSTT3...
- The structure of myostatin: follistatin 288: insights into receptor utilization and heparin binding
[作者：Cash, JN; Rejon, CA; McPherron, AC; Bernard, DJ; Thompson, TB,期刊：EMBO journal, 页码：2662-2676 , 文章类型： Article，,卷期：2009年28-17]
- Myostatin is a member of the transforming growth factor-beta (TGF-beta) family and a strong negative regulator of muscle growth. Here, we present the crystal structure of myostatin in complex with the antagonist follista...
- Structural basis of GDP release and gating in G protein coupled Fe2+ transport
[作者：Guilfoyle, A; Maher, MJ; Rapp, M; Clarke, R; Harrop, S; Jormakka, M,期刊：EMBO journal, 页码：2677-2685 , 文章类型： Article，,卷期：2009年28-17]
- G proteins are key molecular switches in the regulation of membrane protein function and signal transduction. The prokaryotic membrane protein FeoB is involved in G protein coupled Fe2+ transport, and is unique in that t...
- The Neandertal genome and ancient DNA authenticity
[作者：Green, RE; Briggs, AW; Krause, J; Prufer, K; Burbano, HA; Siebauer, M; Lachmann, M; Paabo, S,期刊：EMBO journal, 页码：2494-2502 , 文章类型： Review，,卷期：2009年28-17]
- Recent advances in high-throughput DNA sequencing have made genome-scale analyses of genomes of extinct organisms possible. With these new opportunities come new difficulties in assessing the authenticity of the DNA sequ...
- TERRA: telomeric repeat-containing RNA
[作者：Luke, B; Lingner, J,期刊：EMBO journal, 页码：2503-2510 , 文章类型： Review，,卷期：2009年28-17]
- Telomeres, the physical ends of eukaryotic chromosomes, consist of tandem arrays of short DNA repeats and a large set of specialized proteins. A recent analysis has identified telomeric repeat-containing RNA ( TERRA), a ...
- The life and miracles of kinetochores
[作者：Santaguida, S; Musacchio, A,期刊：EMBO journal, 页码：2511-2531 , 文章类型： Review，,卷期：2009年28-17]
- Kinetochores are large protein assemblies built on chromosomal loci named centromeres. The main functions of kinetochores can be grouped under four modules. The first module, in the inner kinetochore, contributes a sturd...
- Telomeres and disease
[作者：Lansdorp, PM,期刊：EMBO journal, 页码：2532-2540 , 文章类型： Review，,卷期：2009年28-17]
- The telomeres of most eukaryotes are characterized by guanine-rich repeats synthesized by the reverse transcriptase telomerase. Complete loss of telomerase is tolerated for several generations in most species, but modest...
- Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2
[作者：Luo, SW; Zhang, C; Zhang, B; Kim, CH; Qiu, YZ; Du, QS; Mei, L; Xiong, WC,期刊：EMBO journal, 页码：2568-2582 , 文章类型： Article，,卷期：2009年28-17]
- Focal adhesion kinase (FAK), a major cell adhesion-activated tyrosine kinase, has an important function in cell adhesion and migration. Here, we report a new signalling of FAK in regulating chromatin remodelling by its i...
- DNA polymerase epsilon, acetylases and remodellers cooperate to form a specialized chromatin structure at a tRNA insulator
[作者：Dhillon, N; Raab, J; Guzzo, J; Szyjka, SJ; Gangadharan, S; Aparicio, OM; Andrews, B; Kamakaka, RT,期刊：EMBO journal, 页码：2583-2600 , 文章类型： Article，,卷期：2009年28-17]
- Insulators bind transcription factors and use chromatin remodellers and modifiers to mediate insulation. In this report, we identified proteins required for the efficient formation and maintenance of a specialized chroma...
- PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination
[作者：Bryant, HE; Petermann, E; Schultz, N; Jemth, AS; Loseva, O; Issaeva, N; Johansson, F; Fernandez, S; McGlynn, P; Helleday, T,期刊：EMBO journal, 页码：2601-2615 , 文章类型： Article，,卷期：2009年28-17]
- If replication forks are perturbed, a multifaceted response including several DNA repair and cell cycle checkpoint pathways is activated to ensure faithful DNA replication. Here, we show that poly(ADP-ribose) polymerase ...
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