Cohesin's dual role in the DNA damage response: repair and checkpoint activation

[摘要]：Using cohesion to keep a broken chromatid in close proximity to its intact sister chromatid, thereby supporting efficient repair, is a straightforward concept. The responsible protein complex, cohesin, has at least one additional role in the DNA damage response. As Watrin and Peters show in this issue, cohesin, but not cohesion, is required for G1, intra-S and G2-M DNA damage checkpoints. As our knowledge of the distinct functions and properties of cohesin and related complexes expands, it becomes every fundamental reaction that concerns chromosomes. Not surprisingly, the questions do not become fewer.

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