- A New FOXO Pathway Required for Leukemogenesis
[作者：Downing, JR,期刊：Cell, 页码：669-670 , 文章类型： Editorial Material，,卷期：2011年146-5]
- In cancer, the FOXO family of transcription factors functions as tumor suppressors and is directly inactivated by oncogenic signaling through the PI3K/AKT pathway. Now, Skykes et al. (2011) identify a paradoxical require...
- When T Cells Run Out of Breath: The HIF-1 alpha Story
[作者：Nutsch, K; Hsieh, C,期刊：Cell, 页码：673-674 , 文章类型： Editorial Material，,卷期：2011年146-5]
- In this issue, Dang et al. (2011) report a role for the hypoxia-induced transcription factor HIF-1 alpha in regulating the differentiation of T cell subsets that impact both inflammation and its resolution. Their finding...
- Basal Synaptic Transmission: Astrocytes Rule!
[作者：Navarrete, M; Araque, A,期刊：Cell, 页码：675-677 , 文章类型： Editorial Material，,卷期：2011年146-5]
- In this issue, Panatier et al. (2011) show that astrocytes detect synaptic activity induced by single action potentials and upregulate basal synaptic transmission through calcium-dependent mechanisms and purinergic signa...
- Niche Crosstalk: Intercellular Signals at the Hair Follicle
[作者：Jahoda, CAB; Christiano, AM,期刊：Cell, 页码：678-681 , 文章类型： Review，,卷期：2011年146-5]
- A recent series of papers, including Festa et al. (2011) in this issue, has revealed unexpected interdependent relationships among cell populations residing in and around the hair follicle. These interactions between dif...
- Autophagy and Aging
[作者：Rubinsztein, DC; Marino, G; Kroemer, G,期刊：Cell, 页码：682-695 , 文章类型： Review，,卷期：2011年146-5]
- Genetic inhibition of autophagy induces degenerative changes in mammalian tissues that resemble those associated with aging, and normal and pathological aging are often associated with a reduced autophagic potential. Pha...
- AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias
[作者：Sykes, SM; Lane, SW; Bullinger, L; Kalaitzidis, D; Yusuf, R; Saez, B; Ferraro, F; Mercier, F; Singh, H; Brumme, KM; Acharya, SS; Scholl, C; Tothova, Z; Attar, EC; Frohling, S; DePinho, RA; Armstrong, SA; Gilliland, DG; Scadden, DT,期刊：Cell, 页码：697-708 , 文章类型： Article，,卷期：2011年146-5]
- AKT activation is associated with many malignancies, where AKT acts, in part, by inhibiting FOXO tumor suppressors. We show a converse role for AKT/FOXOs in acute myeloid leukemia (AML). Rather than decreased FOXO activi...
- Control of Embryonic Stem Cell Lineage Commitment by Core Promoter Factor, TAF3
[作者：Liu, Z; Scannell, DR; Eisen, MB; Tjian, R,期刊：Cell, 页码：720-731 , 文章类型： Article，,卷期：2011年146-5]
- Deciphering the molecular basis of pluripotency is fundamental to our understanding of development and embryonic stem cell function. Here, we report that TAF3, a TBP-associated core promoter factor, is highly enriched in...
- A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca(2+)/Calmodulin-Dependent Kinase II Holoenzyme
[作者：Chao, LH; Stratton, MM; Lee, IH; Rosenberg, OS; Levitz, J; Mandell, DJ; Kortemme, T; Groves, JT; Schulman, H; Kuriyan, J,期刊：Cell, 页码：732-745 , 文章类型： Article，,卷期：2011年146-5]
- Calcium/calmodulin-dependent kinase II (CaMKII) forms a highly conserved dodecameric assembly that is sensitive to the frequency of calcium pulse trains. Neither the structure of the dodecameric assembly nor how it regul...
- Rescue of Delta F508-CFTR Trafficking via a GRASP-Dependent Unconventional Secretion Pathway
[作者：Gee, HY; Noh, SH; Tang, BL; Kim, KH; Lee, MG,期刊：Cell, 页码：746-760 , 文章类型： Article，,卷期：2011年146-5]
- The most prevalent disease-causing mutation of CFTR is the deletion of Phe508 (Delta F508), which leads to defects in conventional Golgi-mediated exocytosis and cell surface expression. We report that Delta F508-CFTR sur...
- Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling
[作者：Festa, E; Fretz, J; Berry, R; Schmidt, B; Rodeheffer, M; Horowitz, M; Horsley, V,期刊：Cell, 页码：761-771 , 文章类型： Article，,卷期：2011年146-5]
- In mammalian skin, multiple types of resident cells are required to create a functional tissue and support tissue homeostasis and regeneration. The cells that compose the epithelial stem cell niche for skin homeostasis a...
- Control of T(H)17/T(reg) Balance by Hypoxia-Inducible Factor 1
[作者：Dang, EV; Barbi, J; Yang, HY; Jinasena, D; Yu, H; Zheng, Y; Bordman, Z; Fu, J; Kim, Y; Yen, HR; Luo, WB; Zeller, K; Shimoda, L; Topalian, SL; Semenza, GL; Dang, CV; Pardoll, DM; Pan, F,期刊：Cell, 页码：772-784 , 文章类型： Article，,卷期：2011年146-5]
- T cell differentiation into distinct functional effector and inhibitory subsets is regulated, in part, by the cytokine environment present at the time of antigen recognition. Here, we show that hypoxia-inducible factor 1...
- Astrocytes Are Endogenous Regulators of Basal Transmission at Central Synapses
[作者：Panatier, A; Vallee, J; Haber, M; Murai, KK; Lacaille, JC; Robitaille, R,期刊：Cell, 页码：785-798 , 文章类型： Article，,卷期：2011年146-5]
- Basal synaptic transmission involves the release of neurotransmitters at individual synapses in response to a single action potential. Recent discoveries show that astrocytes modulate the activity of neuronal networks up...
- Peptidoglycan Remodeling and Conversion of an Inner Membrane into an Outer Membrane during Sporulation
[作者：Tocheva, EI; Matson, EG; Morris, DM; Moussavi, F; Leadbetter, JR; Jensen, GJ,期刊：Cell, 页码：799-812 , 文章类型： Article，,卷期：2011年146-5]
- Two hallmarks of the Firmicute phylum, which includes the Bacilli and Clostridia classes, are their ability to form endospores and their "Gram-positive'' single-membraned, thick-cell-wall envelope structure. Acetonema lo...
- Photoconversion and Nuclear Trafficking Cycles Determine Phytochrome A's Response Profile to Far-Red Light
[作者：Rausenberger, J; Tscheuschler, A; Nordmeier, W; Wust, F; Timmer, J; Schafer, E; Fleck, C; Hiltbrunner, A,期刊：Cell, 页码：813-825 , 文章类型： Article，,卷期：2011年146-5]
- Phytochrome A (phyA) is the only photoreceptor in plants, initiating responses in far-red light and, as such, essential for survival in canopy shade. Although the absorption and the ratio of active versus total phyA are ...
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