When T Cells Run Out of Breath: The HIF-1 alpha Story

[摘要]：In this issue, Dang et al. (2011) report a role for the hypoxia-induced transcription factor HIF-1 alpha in regulating the differentiation of T cell subsets that impact both inflammation and its resolution. Their findings illustrate how metabolic signals can alter the balance between inflammation and tolerance and present a potential therapeutic opportunity for the treatment of diseases associated with chronic inflammation.

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