- A Novel Monocarbonyl Analogue of Curcumin, (1E,4E)-1,5-Bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one, Induced Cancer Cell H460 Apoptosis via Activation of Endoplasmic Reticulum Stress Signaling Pathway
[作者:WANG YI; XIAO JIAN; ZHOU HUIPING; YANG SHULIN; WU XIAOPING; JIANG CHENGXI; ZHAO YUNJIE; LIANG DONGLOU; LI XIAOKUN; LIANG GUANG,期刊:Journal of Medicinal Chemistry, 页码:3768-3778 , 文章类型: Article,,卷期:2011年54-11]
- Endoplasmic reticulum (ER) stress-induced cancer cell apoptosis has become a novel signaling target for development of cancer therapeutic drugs. Curcumin exhibits growth-suppressive activity against a variety of cancer c...
- Discovery and Characterizatlion of Small Molecule Inhibitors of the BET Family Bromodomains
[作者:CHUNG CHUNWA; COSTE HERVE; WHITE JULIA H; MIRGUET OLIVIER; WILDE JONATHAN; GOSMINI ROMAIN L; DELVES CHRIS; MAGNY SYLVIE M; WOODWARD ROBERT; HUGHES STEPHEN A; BOURSIER ERIC V; FLYNN HELEN; BOUILLOT ANNE M; BAMBOROUGH PAUL; BRUSQ JEANMARIE G; GELLIBERT FRANCOISE J; JONES EMMA J; RIOU ALIZON M; HOMES PAUL; MARTIN SANDRINE L; UINGS IAIN J; TOUM JEROME; CLEMENT CATHERINE A; BOULLAY ANNEBENEDICTE; GRIMLEY RACHEL L; BLANDE FLORENCE M; PRINJHA RAB K; LEE KEVIN; KIRILOVSKY JORGE; NICODEME EDWIGE,期刊:Journal of Medicinal Chemistry, 页码:3827-3838 , 文章类型: Article,,卷期:2011年54-11]
- Epigenetic mechanisms of gene regulation have a profound role in normal development and disease processes. An integral part of this mechanism occurs through lysine acetylation of histone tails which are recognized by bro...
- Highly Potent Activity of (1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol in Animal Models of Parkinson's Disease
[作者:ARDASHOV OLEG V; PAVLOVA ALLA V; ILINA IRINA V; MOROZOVA EKATERINA A; KORCHAGINA DINA V; KARPOVA ELENA V; VOLCHO KONSTANTIN P; TOLSTIKOVA TATYANA G; SALAKHUTDINOV NARIMAN F,期刊:Journal of Medicinal Chemistry, 页码:3866-3874 , 文章类型: Article,,卷期:2011年54-11]
- (1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol 1 possesses potent antiparkinsonian activity in both MPTP and haloperidol animal models. The use of compound 1 resulted in nearly full recovery of the locomot...
- Development of the Fluorescent Biosensor hCalmodulin (hCaM)L39C-monobromobimane(mBBr)/V91C-mBBr, a Novel Tool for Discovering New Calmodulin Inhibitors and Detecting Calcium
[作者:GONZALEZANDRADE MARTIN; RIVERACHAVEZ JOSE; SOSAPEINADO ALEJANDRO; FIGUEROA MARIO; RODRIGUEZSOTRES ROGELIO; MATA RACHEL,期刊:Journal of Medicinal Chemistry, 页码:3875-3884 , 文章类型: Article,,卷期:2011年54-11]
- A novel, sensible, and specific fluorescent biosensor of human calmodulin (hCaM), namely hCaM L39C-mBBr/V91C-mBBr, was constructed. The biosensor was useful for detecting ligands with opposing fluorescent signals, calciu...
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