- Discovery of Indeno[1,2-c]quinoline Derivatives as Inhibitors of Osteoclastogenesis Induced by Receptor Activator of NF-kappa B Ligand (RANKL)
[作者:TSENG CHIHHUA; LIN RUWEI; CHEN YEHLONG; WANG GWOJAW; HO MEILING; TZENG CHERNGCHYI,期刊:Journal of Medicinal Chemistry, 页码:3103-3107 , 文章类型: Article,,卷期:2011年54-8]
- Certain indeno[1,2-c]quinolines were synthesized and evaluated for antiosteoclastogenic activities. Among them, 6,9-dimethoxy-11H-indeno[1,2-c]quinolin-11-one (8a) and 9-methoxy-6-(methylthio)-11H-indeno[1,2-c]quinolin-1...
- Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4-d]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study
[作者:RADI MARCO; DREASSI ELENA; BRULLO CHIARA; CRESPAN EMMANUELE; TINTORI CRISTINA; BERNARDO VINCENZO; VALOTI MASSIMO; ZAMPERINI CLAUDIO; DAIGL HENRY; MUSUMECI FRANCESCA; CARRARO FABIO; NALDINI ANTONELLA; FILIPPI IRENE; MAGA GIOVANNI; SCHENONE SILVIA; BOTTA MAURIZIO,期刊:Journal of Medicinal Chemistry, 页码:2610-2626 , 文章类型: Article,,卷期:2011年54-8]
- A family of dual Src/Abl inhibitors characterized by a substituted pyrazolo[3,4-d]pyrimidine scaffold was previously reported by us and proved to be active against several tumor cell lines. Among these compounds, a promi...
- Synthesis and Separation of the Enantiomers of the Neuropeptide S Receptor Antagonist (9R/S)-3-Oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic Acid 4-Fluoro-benzylamide (SHA 68)
[作者:TRAPELLA CLAUDIO; PELA MICHELA; DEL ZOPPO UISA; CALO GIROLAMO; CAMARDA VALERIA; RUZZA CHIARA; CAVAZZINI ALBERLO; COSTA VALENTINA; BERTOLASI VALERIO; REINSCHEID RAINER K; SALVADORI SEVERO; GUERRINI REMO,期刊:Journal of Medicinal Chemistry, 页码:2738-2744 , 文章类型: Article,,卷期:2011年54-8]
- This study reports the synthesis, chromatographic separation, and pharmacological evaluation of the two enantiomers of the neuropeptide S receptor (NPSR) antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyra...
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