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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共18条记录   Raising the bar [作者：ANONYMOUS,期刊：NATURE CHEMICAL BIOLOGY, 页码：669-669 , 文章类型： Editorial Material，,卷期：2012年8-8] A new era of GPCR structural and chemical biology [作者：GRANIER SEBASTIEN; KOBILKA BRIAN,期刊：NATURE CHEMICAL BIOLOGY, 页码：670-673 , 文章类型： Article，,卷期：2012年8-8] G protein-coupled receptors (GPCRs) are versatile molecular machines that regulate the majority of physiological responses to chemically diverse hormones and neurotransmitters. Recent breakthroughs in structural studies ... Where have all the active receptor states gone? [作者：ONARAN H ONGUN; COSTA TOMMASO,期刊：NATURE CHEMICAL BIOLOGY, 页码：674-677 , 文章类型： Article，,卷期：2012年8-8] Defining G protein-coupled receptor ligand efficacy and biased agonism in precise chemical terms is one challenge posed by the current structural data that exists for this receptor family. Concepts classically used for u... METALS Ironing out copper toxicity [作者：GARENAUX AMELIE; DOZOIS CHARLES M,期刊：NATURE CHEMICAL BIOLOGY, 页码：680-681 , 文章类型： News Item，,卷期：2012年8-8] MICROBIOLOGY Sensing stability [作者：NEVES DAVID; DESSEN ANDREA,期刊：NATURE CHEMICAL BIOLOGY, 页码：681-682 , 文章类型： News Item，,卷期：2012年8-8] Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology [作者：GLOSTER TRACEY M; VOCADLO DAVID J,期刊：NATURE CHEMICAL BIOLOGY, 页码：683-694 , 文章类型： Review，,卷期：2012年8-8] Glycoconjugates are ubiquitous biomolecules found in all kingdoms of life. These diverse structures are metabolically responsive and occur in a cell line-and protein-specific manner, conferring tissue type-specific prope... Lys34 of translation elongation factor EF-P is hydroxylated by YfcM [作者：PEIL LAURI; STAROSTA AGATA L; VIRUMAEE KAI; ATKINSON GEMMA C; TENSON TANEL; REMME JAANUS; WILSON DANIEL N,期刊：NATURE CHEMICAL BIOLOGY, 页码：695-697 , 文章类型： Article，,卷期：2012年8-8] Lys34 of the conserved translation elongation factor P (EF-P) is post-translationally lysinylated by YjeK and YjeA-a modification that is critical for bacterial virulence. Here we show that the currently accepted Escheri... Metallo-beta-lactamases withstand low Zn(II) conditions by tuning metal-ligand interactions [作者：GONZALEZ JAVIER M; MEINI MARIAROCIO; TOMATIS PABLO E; MEDRANO MARTIN FRANCISCO J; CRICCO JULIA A; VILA ALEJANDRO J,期刊：NATURE CHEMICAL BIOLOGY, 页码：698-700 , 文章类型： Article，,卷期：2012年8-8] A number of multiresistant bacterial pathogens inactivate antibiotics by producing Zn(II)-dependent beta-lactamases. We show that metal uptake leading to an active dinuclear enzyme in the periplasmic space of Gram-negati... Phenylalanine assembly into toxic fibrils suggests amyloid etiology in phenylketonuria [作者：ADLERABRAMOVICH LIHI; VAKS LILACH; CARNY OHAD; TRUDLER DORIT; MAGNO ANDREA; CAFLISCH AMEDEO; FRENKEL DAN; GAZIT EHUD,期刊：NATURE CHEMICAL BIOLOGY, 页码：701-706 , 文章类型： Article，,卷期：2012年8-8] Phenylketonuria (PKU) is characterized by phenylalanine accumulation and progressive mental retardation caused by an unknown mechanism. We demonstrate that at pathological concentrations, phenylalanine self-assembles int... Quality control of disulfide bond formation in pilus subunits by the chaperone FimC [作者：CRESPO MARIA D; PUORGER CHASPER; SCHAERER MARTIN A; EIDAM OLIV; GRUETTER MARKUS G; CAPITANI GUIDO; GLOCKSHUBER RUDI,期刊：NATURE CHEMICAL BIOLOGY, 页码：707-713 , 文章类型： Article，,卷期：2012年8-8] Type 1 pili from uropathogenic Escherichia coli are filamentous, noncovalent protein complexes mediating bacterial adhesion to the host tissue. All structural pilus subunits are homologous proteins sharing an invariant d... Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration [作者：NISHIDA MOTOHIRO; SAWA TOMOHIRO; KITAJIMA NAOYUKI; ONO KATSUHIKO; INOUE HIROFUMI; IHARA HIDESHI; MOTOHASHI HOZUMI; YAMAMOTO MASAYUKI; SUEMATSU MAKOTO; KUROSE HITOSHI; VAN DER VLIET ALBERT; FREEMAN BRUCE A; SHIBATA TAKAHIRO; UCHIDA KOJI; KUMAGAI YOSHITO; AKAIKE TAKAAKI,期刊：NATURE CHEMICAL BIOLOGY, 页码：714-724 , 文章类型： Article，,卷期：2012年8-8] An emerging aspect of redox signaling is the pathway mediated by electrophilic byproducts, such as nitrated cyclic nucleotide (for example, 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP)) and nitro or keto de... Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR [作者：ERSOY BARAN A; PARDO LEONARDO; ZHANG SUMEI; THOMPSON DARREN A; MILLHAUSER GLENN; GOVAERTS CEDRIC; VAISSE CHRISTIAN,期刊：NATURE CHEMICAL BIOLOGY, 页码：725-730 , 文章类型： Article，,卷期：2012年8-8] Most of our understanding of G protein-coupled receptor (GPCR) activation has been focused on the direct interaction between diffusible ligands and their seven-transmembrane domains. However, a number of these receptors ... The siderophore yersiniabactin binds copper to protect pathogens during infection [作者：CHATURVEDI KAVERI S; HUNG CHIA S; CROWLEY JAN R; STAPLETON ANN E; HENDERSON JEFFREY P,期刊：NATURE CHEMICAL BIOLOGY, 页码：731-736 , 文章类型： Article，,卷期：2012年8-8] Bacterial pathogens secrete chemically diverse iron chelators called siderophores, which may exert additional distinctive functions in vivo. Among these, uropathogenic Escherichia coli often coexpress the virulence-assoc... A biosensor generated via high-throughput screening quantifies cell edge Src dynamics (vol 7, pg 437, 2011) [作者：GULYANI AKASH; VITRIOL ERIC; ALLEN RICHARD; WU JIANRONG; GREMYACHINSKIY DMITRIY; LEWIS STEVEN; DEWAR BRIAN; GRAVES LEE M; KAY BRIAN K; KUHLMAN BRIAN; ELSTON TIM; HAHN KLAUS M,期刊：NATURE CHEMICAL BIOLOGY, 页码：737-737 , 文章类型： Correction，,卷期：2012年8-8] Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site (vol 8, pg 78, 2012) [作者：NIETOPOSADAS ANDRES; PICAZOJUAREZ GIOVANNI; LLORENTE ITZEL; JARAOSEGUERA ANDRES; MORALESLAZARO SARA; ESCALANTEALCALDE DIANA; ISLAS LEON D; ROSENBAUM TAMARA,期刊：NATURE CHEMICAL BIOLOGY, 页码：737-737 , 文章类型： Correction，,卷期：2012年8-8] A selective inhibitor reveals PI3K gamma dependence of T(H)17 cell differentiation (vol 8, pg 576, 2012) [作者：BERGAMINI GIOVANNA; BELL KATHRYN; SHIMAMURA SATOKO; WERNER THILO; CANSFIELD ANDREW; MUELLER KATRIN; PERRIN JESSICA; RAU CHRISTINA; ELLARD KATIE; HOPF CARSTEN; DOCE CAROLA; LEGGATE DANIEL; MANGANO RAFFAELLA; MATHIESON TOBY; OMAHONY ALISON; PLAVEC IVAN; RHARBAOUI FAIZA; REINHARD FRIEDRICH; SAVITSKI MIKHAIL M; RAMSDEN NIGEL; HIRSCH EMILIO; DREWES GERARD; RAUSCH OLIVER; BANTSCHEFF MARCUS; NEUBAUER GITTE,期刊：NATURE CHEMICAL BIOLOGY, 页码：737-737 , 文章类型： Correction，,卷期：2012年8-8]