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A new era of GPCR structural and chemical biology

  作者 GRANIER SEBASTIEN; KOBILKA BRIAN  
  选自 期刊  NATURE CHEMICAL BIOLOGY;  卷期  2012年8-8;  页码  670-673  
  关联知识点  
 

[摘要]G protein-coupled receptors (GPCRs) are versatile molecular machines that regulate the majority of physiological responses to chemically diverse hormones and neurotransmitters. Recent breakthroughs in structural studies have advanced our understanding of GPCR signaling, particularly the selectivity of ligand recognition and receptor activation of G proteins.

 
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