- Disruption of Hexokinase II-Mitochondrial Binding Blocks Ischemic Preconditioning and Causes Rapid Cardiac Necrosis
[作者:Smeele, KMA; Southworth, R; Wu, RX; Xie, CQ; Nederlof, R; Warley, A; Nelson, JK; van Horssen, P; van den Wijngaard, JP; Heikkinen, S; Laakso, M; Koeman, A; Siebes, M; Eerbeek, O; Akar, FG; Ardehali, H; Hollmann, MW; Zuurbier, CJ,期刊:Circulation Research, 页码:1165-U34 , 文章类型: Article,,卷期:2011年108-10]
- Rationale: Isoforms I and II of the glycolytic enzyme hexokinase (HKI and HKII) are known to associate with mitochondria. It is unknown whether mitochondria-bound hexokinase is mandatory for ischemic preconditioning and ...
- The Actin-Binding Protein Girdin and Its Akt-Mediated Phosphorylation Regulate Neointima Formation After Vascular Injury
[作者:Miyake, H; Maeda, K; Asai, N; Shibata, R; Ichimiya, H; Isotani-Sakakibara, M; Yamamura, Y; Kato, K; Enomoto, A; Takahashi, M; Murohara, T,期刊:Circulation Research, 页码:1170-U65 , 文章类型: Article,,卷期:2011年108-10]
- Rationale: It is well established that the migration and proliferation of vascular smooth muscle cells (VSMCs) have major roles in the vascular remodeling process. Our previous study showed that the Akt substrate Girdin,...
- SIRT1 Acts as a Modulator of Neointima Formation Following Vascular Injury in Mice
[作者:Li, L; Zhang, HN; Chen, HZ; Gao, P; Zhu, LH; Li, HL; Lv, X; Zhang, QJ; Zhang, R; Wang, Z; She, ZG; Zhang, R; Wei, YS; Du, GH; Liu, DP; Liang, CC,期刊:Circulation Research, 页码:1180-U95 , 文章类型: Article,,卷期:2011年108-10]
- Rationale: Vascular smooth muscle cell (VSMC) proliferation and migration are crucial events involved in the pathophysiology of vascular diseases. Sirtuin 1 (SIRT1), a class III histone deacetylase (HDAC), has been repor...
- Orai1 and CRAC Channel Dependence of VEGF-Activated Ca2+ Entry and Endothelial Tube Formation
[作者:Li, J; Cubbon, RM; Wilson, LA; Amer, MS; McKeown, L; Hou, B; Majeed, Y; Tumova, S; Seymour, VAL; Taylor, H; Stacey, M; O'Regan, D; Foster, R; Porter, KE; Kearney, MT; Beech, DJ,期刊:Circulation Research, 页码:1190-U131 , 文章类型: Article,,卷期:2011年108-10]
- Rationale: Orai1 and the associated calcium release-activated calcium (CRAC) channel were discovered in the immune system. Existence also in endothelial cells has been suggested, but the relevance to endothelial biology ...
- The Ras Activator RasGRP3 Mediates Diabetes-Induced Embryonic Defects and Affects Endothelial Cell Migration
[作者:Randhawa, PK; Rylova, S; Heinz, JY; Kiser, S; Fried, JH; Dunworth, WP; Anderson, AL; Barber, AT; Chappell, JC; Roberts, DM; Bautch, VL,期刊:Circulation Research, 页码:1199-U156 , 文章类型: Article,,卷期:2011年108-10]
- Rationale: Fetuses that develop in diabetic mothers have a higher incidence of birth defects that include cardiovascular defects, but the signaling pathways that mediate these developmental effects are poorly understood....
- Chronic Electrical Neuronal Stimulation Increases Cardiac Parasympathetic Tone by Eliciting Neurotrophic Effects
[作者:Rana, OR; Saygili, E; Gemein, C; Zink, MDH; Buhr, A; Saygili, E; Mischke, K; Nolte, KW; Weis, J; Weber, C; Marx, N; Schauerte, P,期刊:Circulation Research, 页码:1209-U172 , 文章类型: Article,,卷期:2011年108-10]
- Rationale: Recently, we provided a technique of chronic high-frequency electric stimulation (HFES) of the right inferior ganglionated plexus for ventricular rate control during atrial fibrillation in dogs and humans. In ...
- Repeated Remote Ischemic Postconditioning Protects Against Adverse Left Ventricular Remodeling and Improves Survival in a Rat Model of Myocardial Infarction
[作者:Wei, M; Xin, P; Li, SA; Tao, JP; Li, YP; Li, J; Liu, MY; Li, JB; Zhu, W; Redington, AN,期刊:Circulation Research, 页码:1220-U199 , 文章类型: Article,,卷期:2011年108-10]
- Rationale: Remote ischemic conditioning induced by repeated episodes of transient limb ischemia is a clinically applicable method for protecting the heart against injury at the time of reperfusion. Objective: To assess t...
- Repair of the Injured Adult Heart Involves New Myocytes Potentially Derived From Resident Cardiac Stem Cells
[作者:Angert, D; Berretta, RM; Kubo, H; Zhang, HY; Chen, XW; Wang, W; Ogorek, B; Barbe, M; Houser, SR,期刊:Circulation Research, 页码:1226-U230 , 文章类型: Article,,卷期:2011年108-10]
- Rationale: The ability of the adult heart to generate new myocytes after injury is not established. Objective: Our purpose was to determine whether the adult heart has the capacity to generate new myocytes after injury, ...
- Intravenous Gene Therapy With PIM-1 Via a Cardiotropic Viral Vector Halts the Progression of Diabetic Cardiomyopathy Through Promotion of Prosurvival Signaling
[作者:Katare, R; Caporali, A; Zentilin, L; Avolio, E; Sala-Newby, G; Oikawa, A; Cesselli, D; Beltrami, AP; Giacca, M; Emanueli, C; Madeddu, P,期刊:Circulation Research, 页码:1238-U265 , 文章类型: Article,,卷期:2011年108-10]
- Rationale: Studies in transgenic mice showed the key role of (Pim-1) (proviral integration site for Moloney murine leukemia virus-1) in the control of cardiomyocyte function and viability. Objective: We investigated whet...
- Microparticles in Hemostasis and Thrombosis
[作者:Owens, AP; Mackman, N,期刊:Circulation Research, 页码:1284-1297 , 文章类型: Review,,卷期:2011年108-10]
- Blood contains microparticles (MPs) derived from a variety of cell types, including platelets, monocytes, and endothelial cells. In addition, tumors release MPs into the circulation. MPs are formed from membrane blebs th...
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