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Disruption of Hexokinase II-Mitochondrial Binding Blocks Ischemic Preconditioning and Causes Rapid Cardiac Necrosis

  作者 Smeele, KMA; Southworth, R; Wu, RX; Xie, CQ; Nederlof, R; Warley, A; Nelson, JK; van Horssen, P; van den Wijngaard, JP; Heikkinen, S; Laakso, M; Koeman, A; Siebes, M; Eerbeek, O; Akar, FG; Ardehali, H; Hollmann, MW; Zuurbier, CJ  
  选自 期刊  Circulation Research;  卷期  2011年108-10;  页码  1165-U34  
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[摘要]Rationale: Isoforms I and II of the glycolytic enzyme hexokinase (HKI and HKII) are known to associate with mitochondria. It is unknown whether mitochondria-bound hexokinase is mandatory for ischemic preconditioning and normal functioning of the intact, b

 
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