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  • Channel-Mediated Tonic GABA Release from Glia
    [作者:Lee, S; Yoon, BE; Berglund, K; Oh, SJ; Park, H; Shin, HS; Augustine, GJ; Lee, CJ,期刊:Science, 页码:790-796 , 文章类型: 期刊论文,,卷期:2010年330-6005]
  • Synaptic inhibition is based on both tonic and phasic release of the inhibitory transmitter gamma-aminobutyric acid (GABA). Although phasic GABA release arises from Ca2+-dependent exocytosis from neurons, the mechanism o...
  • Collaborative Non-Self Recognition System in S-RNase-Based Self-Incompatibility
    [作者:Kubo, K; Entani, T; Takara, A; Wang, N; Fields, AM; Hua, ZH; Toyoda, M; Kawashima, S; Ando, T; Isogai, A; Kao, T; Takayama, S,期刊:Science, 页码:796-799 , 文章类型: 期刊论文,,卷期:2010年330-6005]
  • Self-incompatibility in flowering plants prevents inbreeding and promotes outcrossing to generate genetic diversity. In Solanaceae, a multiallelic gene, S-locus F-box (SLF), was previously shown to encode the pollen dete...
  • The Detection of a Population of Submillimeter-Bright, Strongly Lensed Galaxies
    [作者:Negrello, M; Hopwood, R; De Zotti, G; Cooray, A; Verma, A; Bock, J; Frayer, DT; Gurwell, MA; Omont, A; Neri, R; Dannerbauer, H; Leeuw, LL; Barton, E; Cooke, J; Kim, S; da Cunha, E; Rodighiero, G; Cox, P; Bonfield, DG; Jarvis, MJ; Serjeant, S; Ivison, RJ; ,期刊:Science, 页码:800-804 , 文章类型: 期刊论文,,卷期:2010年330-6005]
  • Gravitational lensing is a powerful astrophysical and cosmological probe and is particularly valuable at submillimeter wavelengths for the study of the statistical and individual properties of dusty star-forming galaxies...
  • Broken-Symmetry States in Doubly Gated Suspended Bilayer Graphene
    [作者:Weitz, RT; Allen, MT; Feldman, BE; Martin, J; Yacoby, A,期刊:Science, 页码:812-816 , 文章类型: 期刊论文,,卷期:2010年330-6005]
  • The single-particle energy spectra of graphene and its bilayer counterpart exhibit multiple degeneracies that arise through inherent symmetries. Interactions among charge carriers should spontaneously break these symmetr...
  • Efficient Atmospheric Cleansing of Oxidized Organic Trace Gases by Vegetation
    [作者:Karl, T; Harley, P; Emmons, L; Thornton, B; Guenther, A; Basu, C; Turnipseed, A; Jardine, K,期刊:Science, 页码:816-819 , 文章类型: 期刊论文,,卷期:2010年330-6005]
  • The biosphere is the major source and sink of nonmethane volatile organic compounds (VOCs) in the atmosphere. Gas-phase chemical reactions initiate the removal of these compounds from the atmosphere, which ultimately pro...
  • Transient Middle Eocene Atmospheric CO2 and Temperature Variations
    [作者:Bijl, PK; Houben, AJP; Schouten, S; Bohaty, SM; Sluijs, A; Reichart, GJ; Damste, JSS; Brinkhuis, H,期刊:Science, 页码:819-821 , 文章类型: 期刊论文,,卷期:2010年330-6005]
  • The long-term warmth of the Eocene (similar to 56 to 34 million years ago) is commonly associated with elevated partial pressure of atmospheric carbon dioxide (pCO(2)). However, a direct relationship between the two has ...
  • Intestinal Stem Cell Replacement Follows a Pattern of Neutral Drift
    [作者:Lopez-Garcia, C; Klein, AM; Simons, BD; Winton, DJ,期刊:Science, 页码:822-825 , 文章类型: 期刊论文,,卷期:2010年330-6005]
  • With the capacity for rapid self-renewal and regeneration, the intestinal epithelium is stereotypical of stem cell-supported tissues. Yet the pattern of stem cell turnover remains in question. Applying analytical methods...
  • Mutational Robustness of Ribosomal Protein Genes
    [作者:Lind, PA; Berg, OG; Andersson, DI,期刊:Science, 页码:825-827 , 文章类型: 期刊论文,,卷期:2010年330-6005]
  • The distribution of fitness effects (DFE) of mutations is of fundamental importance for understanding evolutionary dynamics and complex diseases and for conserving threatened species. DFEs estimated from DNA sequences ha...
  • Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme
    [作者:Wallace, BD; Wang, HW; Lane, KT; Scott, JE; Orans, J; Koo, JS; Venkatesh, M; Jobin, C; Yeh, LA; Mani, S; Redinbo, MR,期刊:Science, 页码:831-835 , 文章类型: 期刊论文,,卷期:2010年330-6005]
  • The dose-limiting side effect of the common colon cancer chemotherapeutic CPT-11 is severe diarrhea caused by symbiotic bacterial beta-glucuronidases that reactivate the drug in the gut. We sought to target these enzymes...
  • The Mechanism for Activation of GTP Hydrolysis on the Ribosome
    [作者:Voorhees, RM; Schmeing, TM; Kelley, AC; Ramakrishnan, V,期刊:Science, 页码:835-838 , 文章类型: 期刊论文,,卷期:2010年330-6005]
  • Protein synthesis requires several guanosine triphosphatase (GTPase) factors, including elongation factor Tu (EF-Tu), which delivers aminoacyl-transfer RNAs (tRNAs) to the ribosome. To understand how the ribosome trigger...
  • Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
    [作者:Ginhoux, F; Greter, M; Leboeuf, M; Nandi, S; See, P; Gokhan, S; Mehler, MF; Conway, SJ; Ng, LG; Stanley, ER; Samokhvalov, IM; Merad, M,期刊:Science, 页码:841-845 , 文章类型: 期刊论文,,卷期:2010年330-6005]
  • Microglia are the resident macrophages of the central nervous system and are associated with the pathogenesis of many neurodegenerative and brain inflammatory diseases; however, the origin of adult microglia remains cont...
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