- Synthesis, structure and structure-activity relationship analysis of 3-tert-butoxycarbonyl-2-arylthiazolidine-4-carboxylic acid derivatives as potential antibacterial agents
[作者:Song, ZC; Ma, GY; Lv, PC; Li, HQ; Xiao, ZP; Zhu, HL,期刊:European Journal of Medicinal Chemistry, 页码:3903-3908 , 文章类型: Article,,卷期:2009年44-10]
- Nine 2-arylthiazolidine-4-carboxylic acid derivatives and nine 3-tert-butoxycarbonyl-2-arylthiazolidine-4-carboxylic acid derivatives were synthesized to screen for their antibacterial activities. Compounds S, 14-18 were...
- 5-Nitro-2-furyl derivative actives against Trypanosoma cruzi: Preliminary in vivo studies
[作者:Cabrera, E; Murguiondo, MG; Arias, MG; Arredondo, C; Pintos, C; Aguirre, G; Fernandez, M; Basmadjian, Y; Rosa, R; Pacheco, JP; Raymondo, S; Di Maio, R; Gonzalez, M; Cerecetto, H,期刊:European Journal of Medicinal Chemistry, 页码:3909-3914 , 文章类型: Article,,卷期:2009年44-10]
- Ten 5-nitro-2-furyl derivatives, with good to excellent in vitro anti-Trypanosoma cruzi activity, and nifurtimox were tested oral and intraperitoneally on healthy animals for its acute toxicity on murine models. Accordin...
- Novel 2,4,5-trisubstituted oxazole derivatives: Synthesis and antiproliferative activity
[作者:Liu, XH; Lv, PC; Xue, JY; Song, BA; Zhu, HL,期刊:European Journal of Medicinal Chemistry, 页码:3930-3935 , 文章类型: Article,,卷期:2009年44-10]
- Microwave irradiation promotes the rapid O,N-acylation-cyclodehydration cascade reaction of oximes and acid chloride. Twenty novel 2,4,5-trisubstituted oxazole derivatives containing heterocycle moiety were synthesized a...
- Novel modified steroid derivatives of androstanolone as chemotherapeutic anti-cancer agents
[作者:El-Far, M; Elmegeed, GA; Eskander, EF; Rady, HM; Tantawy, MA,期刊:European Journal of Medicinal Chemistry, 页码:3936-3946 , 文章类型: Article,,卷期:2009年44-10]
The aim of the present study is to synthesize and evaluate new potential chemotherapeutic anti-tumor agents. Several thiazolo-, pyrido-, pyrano- and lactam steroid derivatives were obtained using 17 beta-hydroxy-5 alp...
- Novel 4-(morpholin-4-yl)-N '-(arylidene)benzohydrazides: Synthesis, antimycobacterial activity and QSAR investigations
[作者:Raparti, V; Chitre, T; Bothara, K; Kumar, V; Dangre, S; Khachane, C; Gore, S; Deshmane, B,期刊:European Journal of Medicinal Chemistry, 页码:3954-3960 , 文章类型: Article,,卷期:2009年44-10]
- A series of 4-(morpholin-4-yl)-N'-(arylidene)benzohydrazides were synthesized using appropriate synthetic route. Anti mycobacterial activity of the synthesized compounds (5a-5j) was carried out and percentage reduction i...
- Chiral gossypol derivatives: Evaluation of their anticancer activity and molecular modeling
[作者:Zhang, L; Jiang, HX; Cao, XX; Zhao, HY; Wang, F; Cui, YX; Jiang, B,期刊:European Journal of Medicinal Chemistry, 页码:3961-3972 , 文章类型: Article,,卷期:2009年44-10]
- To better use gossypol to find promising anticancer compounds, a series of new and known bis-Schiff base analogs of chiral gossypol were synthesized, and their anticancer activity on HeLa, U87 and M85 cells was tested. T...
- Synthesis, characterization, antimicrobial and antitumor screening of some diorganotin(IV) complexes of 2-[(9H-Purin-6-ylimino)]-phenol
[作者:Rehman, W; Badshah, A; Khan, S; Tuyet, LTA,期刊:European Journal of Medicinal Chemistry, 页码:3981-3985 , 文章类型: Article,,卷期:2009年44-10]
- A new series of diorganotin(IV) complexes of the type R2SnL2 (R = Me, Et, Bu, Ph, Bz and L=2-[(9H-Purin-6-ylimino)]-phenol) have been synthesized, characterized by elemental analyses and their solid state configuration h...
- Synthesis, spectroscopic characterization, X-ray structure and evaluation of binding parameters of new triorganotin(IV) dithiocarboxylates with DNA
[作者:Rehman, ZU; Shah, A; Muhammad, N; Ali, S; Qureshi, R; Meetsma, A; Butler, IS,期刊:European Journal of Medicinal Chemistry, 页码:3986-3993 , 文章类型: Article,,卷期:2009年44-10]
- Three new triorganotin(IV) dithiocarboxylates (1-3) with general formula R3SnL, where R=C4H9 (1), C6H11 (2), C6H5 (3) and L=4-(4-nitrophenyl)piperazine-1-carbodithioate, have been synthesized and characterized by element...
- Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives
[作者:Kummerle, AE; Raimundo, JM; Leal, CM; da Silva, GS; Balliano, TL; Pereira, MA; de Simone, CA; Sudo, RT; Zapata-Sudo, G; Fraga, CAM; Barreiro, EJ,期刊:European Journal of Medicinal Chemistry, 页码:4004-4009 , 文章类型: Article,,卷期:2009年44-10]
- In this report we disclose the synthesis, vasodilatory activity, and identification of bioactive conformation of new N-acylhydrazone and N-methyl-N-acylhydrazone derivatives, structurally designed by bioisosteric replace...
- Synthesis and antibacterial activity of novel 15-membered macrolide derivatives: 4 ''-Carbamate, 11,12-cyclic carbonate-4 ''-carbamate and 11,4 ''-di-O-arylcarbamoyl analogs of azithromycin
[作者:Ma, ST; Ma, RX; Liu, ZP; Ma, CC; Shen, XC,期刊:European Journal of Medicinal Chemistry, 页码:4010-4020 , 文章类型: Article,,卷期:2009年44-10]
- 4 ''-Carbamate. 11,12-cyclic carbonate-4 ''-carbamate and 11,4 ''-di-O-arylcarbamoyl analogs of azithromycin were designed, synthesized and evaluated. The 4 ''-carbamate analogs retained excellent activity against erythr...
- Synthesis and characterization of rhenium and technetium-99m tricarbonyl complexes bearing the 4-[3-bromophenyl]quinazoline moiety as a biomarker for EGFR-TK imaging
[作者:Bourkoula, A; Paravatou-Petsotas, M; Papadopoulos, A; Santos, I; Pietzsch, HJ; Livaniou, E; Pelecanou, M; Papadopoulos, M; Pirmettis, I,期刊:European Journal of Medicinal Chemistry, 页码:4021-4027 , 文章类型: Article,,卷期:2009年44-10]
- Aiming at the development of technetium-99m (Tc-99m) complexes for early detection and staging of EGFR positive tumors, the tyrosine kinase inhibitor 6-amino-4-[(3-bromophenyl)amino]quinazoline was derivatized with pyrid...
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