- Hypoxia-inducible Factor 1 alpha Induces Corticosteroid-insensitive Inflammation via Reduction of Histone Deacetylase-2 Transcription
[作者:Charron, CE; Chou, PC; Coutts, DJC; Kumar, V; To, M; Akashi, K; Pinhu, L; Griffiths, M; Adcock, IM; Barnes, PJ; Ito, K,期刊:Journal of Biological Chemistry, 页码:36047-36054 , 文章类型: Article,,卷期:2009年284-52]
- Corticosteroids are potent anti-inflammatory agents, but corticosteroid insensitivity is a major barrier for the treatment of some chronic inflammatory diseases. Here, we show that hypoxia induces corticosteroid-insensit...
- Lack of Oxygen Deactivates Mitochondrial Complex I IMPLICATIONS FOR ISCHEMIC INJURY?
[作者:Galkin, A; Abramov, AY; Frakich, N; Duchen, MR; Moncada, S,期刊:Journal of Biological Chemistry, 页码:36055-36061 , 文章类型: Article,,卷期:2009年284-52]
- For S-nitrosothiols and peroxynitrite to interfere with the activity of mitochondrial complex I, prior transition of the enzyme from its active (A) to its deactive, dormant (D) state is necessary. We now demonstrate accu...
- SHIP2 (SH2 Domain-containing Inositol Phosphatase 2) SH2 Domain Negatively Controls SHIP2 Monoubiquitination in Response to Epidermal Growth Factor
[作者:De Schutter, J; Guillabert, A; Imbault, V; Degraef, C; Erneux, C; Communi, D; Pirson, I,期刊:Journal of Biological Chemistry, 页码:36062-36076 , 文章类型: Article,,卷期:2009年284-52]
- The SH2 domain containing inositol 5-phosphatase SHIP2 contains several interacting domains that are important for scaffolding properties. We and others have previously reported that SHIP2 interacts with the E3 ubiquitin...
- Probing Nuclear Localization Signal-Importin alpha Binding Equilibria in Living Cells
[作者:Cardarelli, F; Bizzarri, R; Serresi, M; Albertazzi, L; Beltram, F,期刊:Journal of Biological Chemistry, 页码:36638-36646 , 文章类型: Article,,卷期:2009年284-52]
- The regulated process of protein import into the nucleus of a eukaryotic cell is mediated by specific nuclear localization signals (NLSs) that are recognized by protein-import receptors. In this study, we present fluores...
- Tissue-specific Short Chain Fatty Acid Metabolism and Slow Metabolic Recovery after Ischemia from Hyperpolarized NMR in Vivo
[作者:Jensen, PR; Peitersen, T; Karlsson, M; in't Zandt, R; Gisselsson, A; Hansson, G; Meier, S; Lerche, MH,期刊:Journal of Biological Chemistry, 页码:36077-36082 , 文章类型: Article,,卷期:2009年284-52]
- Mechanistic details of mammalian metabolism in vivo and dynamic metabolic changes in intact organisms are difficult to monitor because of the lack of spatial, chemical, or temporal resolution when applying traditional an...
- BRCA1 Localization to the Telomere and Its Loss from the Telomere in Response to DNA Damage
[作者:Ballal, RD; Saha, T; Fan, SJ; Haddad, BR; Rosen, EM,期刊:Journal of Biological Chemistry, 页码:36083-36098 , 文章类型: Article,,卷期:2009年284-52]
- BRCA1, a tumor suppressor, participates in DNA damage signaling and repair. Previously, we showed that BRCA1 overexpression caused inhibition of telomerase activity and telomere shortening in breast and prostate cancer c...
- Anti-apoptotic Molecule Bcl-2 Regulates the Differentiation, Activation, and Survival of Both Osteoblasts and Osteoclasts
[作者:Nagase, Y; Iwasawa, M; Akiyama, T; Kadono, Y; Nakamura, M; Oshima, Y; Yasui, T; Matsumoto, T; Hirose, J; Nakamura, H; Miyamoto, T; Bouillet, P; Nakamura, K; Tanaka, S,期刊:Journal of Biological Chemistry, 页码:36659-36669 , 文章类型: Article,,卷期:2009年284-52]
- The anti-apoptotic molecule Bcl-2 inhibits apoptosis by preventing cytochrome c release from mitochondria. Although several studies have indicated the importance of Bcl-2 in maintaining skeletal integrity, the detailed c...
- The Mannitol Operon Repressor MtlR Belongs to a New Class of Transcription Regulators in Bacteria
[作者:Tan, KM; Clancy, S; Borovilos, M; Zhou, M; Horer, S; Moy, S; Volkart, LL; Sassoon, J; Baumann, U; Joachimiak, A,期刊:Journal of Biological Chemistry, 页码:36670-36679 , 文章类型: Article,,卷期:2009年284-52]
- Many bacteria express phosphoenolpyruvate-dependent phosphotransferase systems (PTS). The mannitol-specific PTS catalyze the uptake and phosphorylation of D-mannitol. The uptake system comprises several genes encoded in ...
- A Cell-penetrating Peptide Derived from Human Lactoferrin with Conformation-dependent Uptake Efficiency
[作者:Duchardt, F; Ruttekolk, IR; Verdurmen, WPR; Lortat-Jacob, H; Burck, J; Hufnagel, H; Fischer, R; van den Heuvel, M; Lowik, DWPM; Vuister, GW; Ulrich, A; de Waard, M; Brock, R,期刊:Journal of Biological Chemistry, 页码:36099-36108 , 文章类型: Article,,卷期:2009年284-52]
- The molecular events that contribute to the cellular uptake of cell-penetrating peptides (CPP) are still a matter of intense research. Here, we report on the identification and characterization of a 22-amino acid CPP der...
- A Novel Xylosylphosphotransferase Activity Discovered in Cryptococcus neoformans
[作者:Reilly, MC; Levery, SB; Castle, SA; Klutts, JS; Doering, TL,期刊:Journal of Biological Chemistry, 页码:36118-36127 , 文章类型: Article,,卷期:2009年284-52]
- Cryptococcus neoformans is a fungal pathogen that causes serious disease in immunocompromised individuals. The organism produces a distinctive polysaccharide capsule that is necessary for its virulence, a predominantly p...
- Chemical Validation of Trypanothione Synthetase A POTENTIAL DRUG TARGET FOR HUMAN TRYPANOSOMIASIS
[作者:Torrie, LS; Wyllie, S; Spinks, D; Oza, SL; Thompson, S; Harrison, JR; Gilbert, IH; Wyatt, PG; Fairlamb, AH; Frearson, JA,期刊:Journal of Biological Chemistry, 页码:36137-36145 , 文章类型: Article,,卷期:2009年284-52]
- In the search for new therapeutics for the treatment of human African trypanosomiasis, many potential drug targets in Trypanosoma brucei have been validated by genetic means, but very few have been chemically validated. ...
- Thioredoxin-interacting Protein (Txnip) Is a Feedback Regulator of S-Nitrosylation
[作者:Forrester, MT; Seth, D; Hausladen, A; Eyler, CE; Foster, MW; Matsumoto, A; Benhar, M; Marshall, HE; Stamler, JS,期刊:Journal of Biological Chemistry, 页码:36160-36166 , 文章类型: Article,,卷期:2009年284-52]
- Nitric oxide exerts a plethora of biological effects via protein S-nitrosylation, a redox-based reaction that converts a protein Cys thiol to a S-nitrosothiol. However, although the regulation of protein S-nitrosylation ...
- Biochemical Control of CARM1 Enzymatic Activity by Phosphorylation
[作者:Feng, Q; He, B; Jung, SY; Song, YC; Qin, J; Tsai, SY; Tsai, MJ; O'Malley, BW,期刊:Journal of Biological Chemistry, 页码:36167-36174 , 文章类型: Article,,卷期:2009年284-52]
- Coactivator-associated arginine methyltransferase 1 (CARM1) is a dual functional coregulator that facilitates transcription initiation by methylation of Arg(17) and Arg(26) of histone H3 and also dictates the subsequent ...
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