- Cdc7 Kinase Inhibitors: 5-Heteroaryl-3-Carboxamido-2-Aryl Pyrroles as Potential Antitumor Agents. 1. Lead Finding
[作者:MENICHINCHERI MARIA; ALBANESE CLARA; ALLI CRISTINA; BALLINARI DARIO; BARGIOTTI ALBERTO; CALDARELLI MARINA; CIAVOLELLA ANTONELLA; CIRLA ALESSANDRA; COLOMBO MARISTELLA; COLOTTA FRANCESCO; CROCI VALTER; DALESSIO ROBERTO; DANELLO MATTEO; ERMOTI ANTONELLA; FIORENTINI FRANCESCO; FORTE BARBARA; GALVANI ARTURO; GIORDANO PATRIZIA; ISACCHI ANTONELLA; MARTINA KATIA; MOLINARI ANTONIO; MOLL JUEGEN K; MONTAGNOLI ALESSIA; ORSINI PAOLO; ORZI FABRIZIO; PESENTI ENRICO; PILLAN ANTONIO; ROLETTO FULVIA; SCOLARO ALESSANDRA; TATO MARCO; TIBOLLA MARCELLINO; VALSASINA BARBARA; VARASI MARIO; VIANELLO PAOLA; VOLPI DANIELE; SANTOCANALE CORRADO; VANOTTIT ERMES,期刊:Journal of Medicinal Chemistry, 页码:7296-7315 , 文章类型: Article,,卷期:2010年53-20]
- Cdc7 serine/threonine kinase is a key regulator of DNA synthesis in eukaryotic organisms. Cdc7 inhibition through siRNA or prototype small molecules causes p53 independent apoptosis in tumor cells while reversibly arrest...
- Design, Synthesis, Radiolabeling, and in Vivo Evaluation of Carbon-11 Labeled N-[2-[4-(3-Cyanopyridin-2-yl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a Potential Positron Emission Tomography Tracer for the Dopamine D-4 Receptors
[作者:LACIVITA ENZA; DE GIORGIO PAOLA; LEE IRENE T; RODEHEAVER SEAN I; WEISS BRYAN A; FRACASSO CLAUDIA; CACCIA SILVIO; BERARDI FRANCESCO; PERRONE ROBERTO; ZHANG MINGRONG; MAEDA JUN; HIGUCHI MAKOTO; SUHARA TETSUYA; SCHETZ JOHN A; LEOPOLDO MARCEL,期刊:Journal of Medicinal Chemistry, 页码:7344-7355 , 文章类型: Article,,卷期:2010年53-20]
- Here we describe the design, synthesis, and evaluation of physicochemical and pharmacological properties of D-4 dopamine receptor ligands related to N-[2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide (2). S...
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