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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共18条记录   The glucose signal and metabolic p[H+]lux [作者：Rubenstein, EM; Schmidt, MC,期刊：EMBO journal, 页码：2473-2474 , 文章类型： Editorial Material，,卷期：2010年29-15] Eukaryotes harbour multiple signalling pathways to detect and respond to changes in glucose availability. Some of these pathways use plasma membrane receptors that sense extracellular glucose. Others are responsive to gl... Nanog, Gli, and p53: a new network of stemness in development and cancer [作者：Brandner, S,期刊：EMBO journal, 页码：2475-2476 , 文章类型： Editorial Material，,卷期：2010年29-15] Nanog and Hedgehog (HH) are both essential regulators of stemness by promoting self-renewal in embryonic stem cells, during early embryonal development (Mitsui et al, 2003) and in cancer cells (Jeter et al, 2009). Two gr... Opposing functions of two sub-domains of the SNARE-complex in neurotransmission [作者：Weber, JP; Reim, K; Sorensen, JB,期刊：EMBO journal, 页码：2477-2490 , 文章类型： Article，,卷期：2010年29-15] The SNARE-complex consisting of synaptobrevin-2/VAMP-2, SNAP-25 and syntaxin-1 is essential for evoked neurotransmission and also involved in spontaneous release. Here, we used cultured autaptic hippocampal neurons from ... The peroxisomal receptor Pex19p forms a helical mPTS recognition domain [作者：Schueller, N; Holton, SJ; Fodor, K; Milewski, M; Konarev, P; Stanley, WA; Wolf, J; Erdmann, R; Schliebs, W; Song, YH; Wilmanns, M,期刊：EMBO journal, 页码：2491-2500 , 文章类型： Article，,卷期：2010年29-15] The protein Pex19p functions as a receptor and chaperone of peroxisomal membrane proteins (PMPs). The crystal structure of the folded C-terminal part of the receptor reveals a globular domain that displays a bundle of th... CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response [作者：Maruyama, T; Kadowaki, H; Okamoto, N; Nagai, A; Naguro, I; Matsuzawa, A; Shibuya, H; Tanaka, K; Murata, S; Takeda, K; Nishitoh, H; Ichijo, H,期刊：EMBO journal, 页码：2501-2514 , 文章类型： Article，,卷期：2010年29-15] The extracellular signal-regulated kinase (ERK) pathway is an important signalling pathway that regulates a large number of cellular processes, including proliferation, differentiation and gene expression. Hyperosmotic s... Cytosolic pH is a second messenger for glucose and regulates the PKA pathway through V-ATPase [作者：Dechant, R; Binda, M; Lee, SS; Pelet, S; Winderickx, J; Peter, M,期刊：EMBO journal, 页码：2515-2526 , 文章类型： Article，,卷期：2010年29-15] Glucose is the preferred carbon source for most cell types and a major determinant of cell growth. In yeast and certain mammalian cells, glucose activates the cAMP-dependent protein kinase A (PKA), but the mechanisms of ... The transcription inhibitor lipiarmycin blocks DNA fitting into the RNA polymerase catalytic site [作者：Tupin, A; Gualtieri, M; Leonetti, JP; Brodolin, K,期刊：EMBO journal, 页码：2527-2537 , 文章类型： Article，,卷期：2010年29-15] Worldwide spreading of drug-resistant pathogens makes mechanistic understanding of antibiotic action an urgent task. The macrocyclic antibiotic lipiarmycin (Lpm), which is under development for clinical use, inhibits bac... MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output [作者：Chen, LH; Li, ZY; Zwolinska, AK; Smith, MA; Cross, B; Koomen, J; Yuan, ZM; Jenuwein, T; Marine, JC; Wright, KL; Chen, JD,期刊：EMBO journal, 页码：2538-2552 , 文章类型： Article，,卷期：2010年29-15] MDM2 is a key regulator of the p53 tumor suppressor acting primarily as an E3 ubiquitin ligase to promote its degradation. MDM2 also inhibits p53 transcriptional activity by recruiting histone deacetylase and corepressor... Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor [作者：Maertens, GN; El Messaoudi-Aubert, S; Elderkin, S; Hiom, K; Peters, G,期刊：EMBO journal, 页码：2553-2565 , 文章类型： Article，,卷期：2010年29-15] An important facet of transcriptional repression by Polycomb repressive complex 1 (PRC1) is the mono-ubiquitination of histone H2A by the combined action of the Posterior sex combs (Psc) and Sex combs extra (Sce) protein... Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity [作者：Wang, H; Morita, M; Yang, XN; Suzuki, T; Yang, W; Wang, JA; Ito, K; Wang, QA; Zhao, C; Bartlam, M; Yamamoto, T; Rao, ZH,期刊：EMBO journal, 页码：2566-2576 , 文章类型： Article，,卷期：2010年29-15] CCR4, an evolutionarily conserved member of the CCR4-NOT complex, is the main cytoplasmic deadenylase. It contains a C-terminal nuclease domain with homology to the endonuclease-exonuclease-phosphatase (EEP) family of... Recognition of the amber UAG stop codon by release factor RF1 [作者：Korostelev, A; Zhu, JY; Asahara, H; Noller, HF,期刊：EMBO journal, 页码：2577-2585 , 文章类型： Article，,卷期：2010年29-15] We report the crystal structure of a termination complex containing release factor RF1 bound to the 70S ribosome in response to an amber (UAG) codon at 3.6-angstrom resolution. The amber codon is recognized in the 30S su... Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis [作者：Wilting, RH; Yanover, E; Heideman, MR; Jacobs, H; Horner, J; van der Torre, J; DePinho, RA; Dannenberg, JH,期刊：EMBO journal, 页码：2586-2597 , 文章类型： Article，,卷期：2010年29-15] Histone deacetylases (HDACs) counterbalance acetylation of lysine residues, a protein modification involved in numerous biological processes. Here, Hdac1 and Hdac2 conditional knock-out alleles were used to study the fun... The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres [作者：Rai, R; Zheng, H; He, H; Luo, Y; Multani, A; Carpenter, PB; Chang, S,期刊：EMBO journal, 页码：2598-2610 , 文章类型： Article，,卷期：2010年29-15] Repair of DNA double-stranded breaks (DSBs) is crucial for the maintenance of genome stability. DSBs are repaired by either error prone non-homologous end-joining (NHEJ) or error-free homologous recombination. NHEJ prece... Elg1, an alternative subunit of the RFC clamp loader, preferentially interacts with SUMOylated PCNA [作者：Parnas, O; Zipin-Roitman, A; Pfander, B; Liefshitz, B; Mazor, Y; Ben-Aroya, S; Jentsch, S; Kupiec, M,期刊：EMBO journal, 页码：2611-2622 , 文章类型： Article，,卷期：2010年29-15] Replication-factor C (RFC) is a protein complex that loads the processivity clamp PCNA onto DNA. Elg1 is a conserved protein with homology to the largest subunit of RFC, but its function remained enigmatic. Here, we show... Cellular pathways controlling integron cassette site folding [作者：Loot, C; Bikard, D; Rachlin, A; Mazel, D,期刊：EMBO journal, 页码：2623-2634 , 文章类型： Article，,卷期：2010年29-15] By mobilizing small DNA units, integrons have a major function in the dissemination of antibiotic resistance among bacteria. The acquisition of gene cassettes occurs by recombination between the attI and attC sites catal... Cis interaction between Semaphorin6A and Plexin-A4 modulates the repulsive response to Sema6A [作者：Haklai-Topper, L; Mlechkovich, G; Savariego, D; Gokhman, I; Yaron, A,期刊：EMBO journal, 页码：2635-2645 , 文章类型： Article，,卷期：2010年29-15] The correct navigation of axons to their targets depends on guidance molecules in the extra-cellular environment. Differential responsiveness to a particular guidance cue is largely an outcome of disparity in the express...