- Signal transduction by vascular endothelial growth factor receptors
[作者:Koch, S; Tugues, S; Li, XJ; Gualandi, L; Claesson-Welsh, L,期刊:Biochemical Journal, 页码:169-183 , 文章类型: Review,,卷期:2011年437-Part 2]
- VEGFs (vascular endothelial growth factors) control vascular development during embryogenesis and the function of blood vessels and lymphatic vessels in the adult. There are five related mammalian ligands, which act thro...
- Inhibiting myosin-ATPase reveals a dynamic range of mitochondrial respiratory control in skeletal muscle
[作者:Perry, CGR; Kane, DA; Lin, CT; Kozy, R; Cathey, BL; Lark, DS; Kane, CL; Brophy, PM; Gavin, TP; Anderson, EJ; Neufer, PD,期刊:Biochemical Journal, 页码:215-222 , 文章类型: Article,,卷期:2011年437-Part 2]
- Assessment of mitochondrial ADP-stimulated respiratory kinetics in PmFBs (permeabilized fibre bundles) is increasingly used in clinical diagnostic and basic research settings. However, estimates of the K-m for ADP vary c...
- Tissue- and paralogue-specific functions of acyl-CoA-binding proteins in lipid metabolism in Caenorhabditis elegans
[作者:Elle, IC; Simonsen, KT; Olsen, LCB; Birck, PK; Ehmsen, S; Tuck, S; Le, TT; Faergeman, NJ,期刊:Biochemical Journal, 页码:231-241 , 文章类型: Article,,卷期:2011年437-Part 2]
- ACBP (acyl-CoA-binding protein) is a small primarily cytosolic protein that binds acyl-CoA esters with high specificity and affinity. ACBP has been identified in all eukaryotic species, indicating that it performs a basa...
- Structure and activity of the Saccharomyces cerevisiae dUTP pyrophosphatase DUT1, an essential housekeeping enzyme
[作者:Tchigvintsev, A; Singer, AU; Flick, R; Petit, P; Brown, G; Evdokimova, E; Savchenko, A; Yakunin, AE,期刊:Biochemical Journal, 页码:243-253 , 文章类型: Article,,卷期:2011年437-Part 2]
- Genomes of all free-living organisms encode the enzyme dUTPase (dUTP pyrophosphatase), which plays a key role in preventing uracil incorporation into DNA. In the present paper, we describe the biochemical and structural ...
- Ubiquitin-mediated internalization of connexin43 is independent of the canonical endocytic tyrosine-sorting signal
[作者:Catarino, S; Ramalho, JS; Marques, C; Pereira, P; Girao, H,期刊:Biochemical Journal, 页码:255-267 , 文章类型: Article,,卷期:2011年437-Part 2]
- Gap junctions are specialized cell cell contacts that provide direct intercellular communication between eukaryotic cells. The tyrosine-sorting signal (YXXempty set), present at amino acids 286-289 of Cx43 (connexin43), ...
- A scaffold of accessory subunits links the peripheral arm and the distal proton-pumping module of mitochondrial complex I
[作者:Angerer, H; Zwicker, K; Wumaier, Z; Sokolova, L; Heide, H; Steger, M; Kaiser, S; Nubel, E; Brutschy, B; Radermacher, M; Brandt, U; Zickermann, V,期刊:Biochemical Journal, 页码:279-288 , 文章类型: Article,,卷期:2011年437-Part 2]
- Mitochondrial NADH:ubiquinone oxidoreductase (complex I) is a very large membrane protein complex with a central function in energy metabolism. Complex I from the aerobic yeast Yarrowia lipolytica comprises 14 central su...
- Protein kinase C zeta phosphorylates occludin and promotes assembly of epithelial tight junctions
[作者:Jain, S; Suzuki, T; Seth, A; Samak, G; Rao, R,期刊:Biochemical Journal, 页码:289-299 , 文章类型: Article,,卷期:2011年437-Part 2]
- Protein kinases play an important role in the regulation of epithelial tight junctions. In the present study, we investigated the role of PKC zeta (protein kinase C zeta) in tight junction regulation in Caco-2 and MDCK (...
- Hexokinase II acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration
[作者:Mailloux, RJ; Dumouchel, T; Aguer, C; deKemp, R; Beanlands, R; Harper, ME,期刊:Biochemical Journal, 页码:301-311 , 文章类型: Article,,卷期:2011年437-Part 2]
- UCP3 (uncoupling protein-3) mitigates mitochondrial ROS (reactive oxygen species) production, but the mechanisms are poorly understood. Previous studies have also examined UCP3 effects, including decreased ROS production...
- Cleavage of Notch1 by granzyme B disables its transcriptional activity
[作者:van Tetering, G; Bovenschen, N; Meeldijk, J; van Diest, PJ; Vooijs, M,期刊:Biochemical Journal, 页码:313-322 , 文章类型: Article,,卷期:2011年437-Part 2]
- Granzyme-mediated cell death is the main pathway for cytotoxic lymphocytes to kill virus-infected and tumour cells. A major player in this process is GrB (granzyme B), which triggers apoptosis in both caspase-dependent a...
- Oestrogen causes degradation of KLF5 by inducing the E3 ubiquitin ligase EFP in ER-positive breast cancer cells
[作者:Zhao, KW; Sikriwal, D; Dong, XY; Guo, P; Sun, XD; Dong, JT,期刊:Biochemical Journal, 页码:323-333 , 文章类型: Article,,卷期:2011年437-Part 2]
- KLF5 (Kruppel-like factor 5) is a multifunctional transcription factor involved in cell proliferation, differentiation and carcinogenesis. In addition to frequent inactivation in different types of human cancers, includi...
- Glycogen synthase kinase-3 beta regulates Tyr(307) phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src
[作者:Yao, XQ; Zhang, XX; Yin, YY; Liu, B; Luo, DJ; Liu, D; Chen, NN; Ni, ZF; Wang, X; Wang, Q; Wang, JZ; Liu, GP,期刊:Biochemical Journal, 页码:335-344 , 文章类型: Article,,卷期:2011年437-Part 2]
- GSK-3 beta (glycogen synthase kinase-3 beta), a crucial tau kinase, negatively regulates PP2A (protein phosphatase 2A), the most active tau phosphatase that is suppressed in the brain in AD (Alzheimer's disease). However...
- AW551984: a novel regulator of cardiomyogenesis in pluripotent embryonic cells
[作者:Yasuda, S; Hasegawa, T; Hosono, T; Satoh, M; Watanabe, K; Ono, K; Shimizu, S; Hayakawa, T; Yamaguchi, T; Suzuki, K; Sato, Y,期刊:Biochemical Journal, 页码:345-355 , 文章类型: Article,,卷期:2011年437-Part 2]
- An understanding of the mechanism that regulates the cardiac differentiation of pluripotent stem cells is necessary for the effective generation and expansion of cardiomyocytes as cell therapy products. In the present st...
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