- Proximal Tubular Secretion of Creatinine by Organic Cation Transporter OCT2 in Cancer Patients
[作者：Ciarimboli, G; Lancaster, CS; Schlatter, E; Franke, RM; Sprowl, JA; Pavenstadt, H; Massmann, V; Guckel, D; Mathijssen, RHJ; Yang, WJ; Pui, CH; Relling, MV; Herrmann, E; Sparreboom, A,期刊：Clinical Cancer Research, 页码：1101-1108 , 文章类型： Article，,卷期：2012年18-4]
- Purpose: Knowledge of transporters responsible for the renal secretion of creatinine is key to a proper interpretation of serum creatinine and/or creatinine clearance as markers of renal function in cancer patients recei...
- Gene Expression, Molecular Class Changes, and Pathway Analysis after Neoadjuvant Systemic Therapy for Breast Cancer
[作者：Gonzalez-Angulo, AM; Iwamoto, T; Liu, SY; Chen, HQ; Do, KA; Hortobagyi, GN; Mills, GB; Meric-Bernstam, F; Symmans, WF; Pusztai, L,期刊：Clinical Cancer Research, 页码：1109-1119 , 文章类型： Article，,卷期：2012年18-4]
- Purpose: To examine gene expression differences between pre- and post-neoadjuvant systemic therapy (NST) specimens of breast cancers and identify biologic changers that may lead to new therapeutic insights. Methods: Gene...
- Phase I Study of the Combination of Sorafenib and Temsirolimus in Patients with Metastatic Melanoma
[作者：Davies, MA; Fox, PS; Papadopoulos, NE; Bedikian, AY; Hwu, WJ; Lazar, AJ; Prieto, VG; Culotta, KS; Madden, TL; Xu, QY; Huang, S; Deng, WL; Ng, CS; Gupta, S; Liu, WB; Dancey, JE; Wright, JJ; Bassett, RL; Hwu, P; Kim, KB,期刊：Clinical Cancer Research, 页码：1120-1128 , 文章类型： Article，,卷期：2012年18-4]
- Purpose: This phase I clinical trial was conducted to determine the safety, efficacy, and molecular effects of sorafenib with temsirolimus in patients with advanced melanoma. Patients and Methods: Patients with stage IV ...
- Randomized Phase II Trial of Sorafenib with Temsirolimus or Tipifarnib in Untreated Metastatic Melanoma (S0438)
[作者：Margolin, KA; Moon, J; Flaherty, LE; Lao, CD; Akerley, WL; Othus, M; Sosman, JA; Kirkwood, JM; Sondak, VK,期刊：Clinical Cancer Research, 页码：1129-1137 , 文章类型： Article，,卷期：2012年18-4]
- Purpose: Signaling pathway stimulation by activating mutations of oncogenes occurs in most melanomas and can provide excellent targets for therapy, but the short-term therapeutic success is limited by intrinsic and acqui...
- Phase II Trial of Temozolomide in Patients with Relapsed Sensitive or Refractory Small Cell Lung Cancer, with Assessment of Methylguanine- DNA Methyltransferase as a Potential Biomarker
[作者：Pietanza, MC; Kadota, K; Huberman, K; Sima, CS; Fiore, JJ; Sumner, DK; Travis, WD; Heguy, A; Ginsberg, MS; Holodny, AI; Chan, TA; Rizvi, NA; Azzoli, CG; Riely, GJ; Kris, MG; Krug, LM,期刊：Clinical Cancer Research, 页码：1138-1145 , 文章类型： Article，,卷期：2012年18-4]
- Purpose: This phase II study was conducted to assess the efficacy of temozolomide in patients with relapsed small cell lung cancer (SCLC). Experimental Design: Patients with disease progression after one or two prior che...
- Immunochemotherapy with Intensive Consolidation for Primary CNS Lymphoma: A Pilot Study and Prognostic Assessment by Diffusion- Weighted MRI
[作者：Wieduwilt, MJ; Valles, F; Issa, S; Behler, CM; Hwang, J; McDermott, M; Treseler, P; O'Brien, J; Shuman, MA; Cha, S; Damon, LE; Rubenstein, JL,期刊：Clinical Cancer Research, 页码：1146-1155 , 文章类型： Article，,卷期：2012年18-4]
- Purpose: We evaluated a novel therapy for primary central nervous system lymphoma (PCNSL) with induction immunochemotherapy with high-dose methotrexate, temozolomide, and rituximab (MT-R) followed by intensive consolidat...
- Clarifying the Spectrum of Driver Oncogene Mutations in Biomarker-Verified Squamous Carcinoma of Lung: Lack of EGFR/KRAS and Presence of PIK3CA/AKT1 Mutations
[作者：Rekhtman, N; Paik, PK; Arcila, ME; Tafe, LJ; Oxnard, GR; Moreira, AL; Travis, WD; Zakowski, MF; Kris, MG; Ladanyi, M,期刊：Clinical Cancer Research, 页码：1167-1176 , 文章类型： Article，,卷期：2012年18-4]
- Purpose: There is persistent controversy as to whether EGFR and KRAS mutations occur in pulmonary squamous cell carcinoma (SQCC). We hypothesized that the reported variability may reflect difficulties in the pathologic d...
- Quantitative Cell-Free DNA, KRAS, and BRAF Mutations in Plasma from Patients with Metastatic Colorectal Cancer during Treatment with Cetuximab and Irinotecan
[作者：Spindler, KLG; Pallisgaard, N; Vogelius, I; Jakobsen, A,期刊：Clinical Cancer Research, 页码：1177-1185 , 文章类型： Article，,卷期：2012年18-4]
- Purpose: The present study investigated the levels of circulating cell-free DNA (cfDNA) in plasma from patients with metastatic colorectal cancer (mCRC) in relation to third-line treatment with cetuximab and irinotecan a...
- Does PTEN Loss Impair DNA Double-Strand Break Repair by Homologous Recombination?
[作者：Hunt, CR; Gupta, A; Horikoshi, N; Pandita, TK,期刊：Clinical Cancer Research, 页码：920-922 , 文章类型： Article，,卷期：2012年18-4]
- The tumor suppressor PTEN is frequently lost in cancer cells, resulting in altered radiation and drug sensitivity. However, the role of PTEN in DNA repair is controversial. Detailed studies in prostate cancer cells now i...
- Molecular Pathways: Involvement of Helicobacter pylori-Triggered Inflammation in the Formation of an Epigenetic Field Defect, and Its Usefulness as Cancer Risk and Exposure Markers
[作者：Ushijima, T; Hattori, N,期刊：Clinical Cancer Research, 页码：923-929 , 文章类型： Article，,卷期：2012年18-4]
- Infection-associated cancers account for a large proportion of human cancers, and gastric cancer, the vast majority of which is associated with Helicobacter pylori infection, is a typical example of such cancers. Epigene...
- Molecular Pathways: BCR-ABL
[作者：Cilloni, D; Saglio, G,期刊：Clinical Cancer Research, 页码：930-937 , 文章类型： Article，,卷期：2012年18-4]
- Aberrant tyrosine kinase activity plays a critical role in many hematologic disorders, including chronic myeloid leukemia characterized by the constitutive activity of BCR-ABL. ABL therefore represents a crucial target f...
- Upregulation of Notch2 and Six1 Is Associated with Progression of Early- Stage Lung Adenocarcinoma and a More Aggressive Phenotype at Advanced Stages
[作者：Mimae, T; Okada, M; Hagiyama, M; Miyata, Y; Tsutani, Y; Inoue, T; Murakami, Y; Ito, A,期刊：Clinical Cancer Research, 页码：945-955 , 文章类型： Article，,卷期：2012年18-4]
- Purpose: Lung adenocarcinoma often manifests as tumors with mainly lepidic growth. The size of invasive foci determines a diagnosis of in situ, minimally invasive adenocarcinoma, or invasive types and suggests that some ...
- Toward the Prognostic Significance and Therapeutic Potential of HER3 Receptor Tyrosine Kinase in Human Colon Cancer
[作者：Beji, A; Horst, D; Engel, J; Kirchner, T; Ullrich, A,期刊：Clinical Cancer Research, 页码：956-968 , 文章类型： Article，,卷期：2012年18-4]
- Purpose: Abnormal accumulation and dysregulation of the epidermal growth factor receptor family member HER3 is associated with the development of various human cancers including those of the breast, lung, and ovary. We h...
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