Increasing Potential of HER3 Signaling in Colon Cancer Progression and Therapy

[摘要]：HER3 protein levels at the cancer cell plasma membrane are directly correlated with reduced survival in patients with colorectal cancer. In colorectal cancer cells, HER3 blockade restricted cellular growth (G(2)-M arrest), survival, migration, and invasion, and potentiated the chemotherapeutic effect of 5-FU, supporting strategies that target HER3 in subsets of patients with colorectal cancer. Clin Cancer Res; 18(4); 917-9. (C) 2011 AACR.

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