- Synthesis of 3-((2,4-dichlorophenoxy)methyl)-1,2,4-triazolo(thiadiazoles and thiadiazines) as anti-inflammatory and molluscicidal agents
[作者:El Shehry, MF; Abu-Hashem, AA; El-Telbani, EM,期刊:European Journal of Medicinal Chemistry, 页码:1906-1911 , 文章类型: Article,,卷期:2010年45-5]
- A series of fused and non fused 1,2,4-triazoles with (2,4-dichlorophenoxy) moiety are prepared utilizing 3-((2,4-dichlorophenoxy)methyl)-4-amino-4H-1,2,4-triazole-5-thiol (3). The latter on reaction with carboxylic acids...
- Reaction mechanisms of allicin and allyl-mixed disulfides with proteins and small thiol molecules
[作者:Miron, T; Listowsky, I; Wilchek, M,期刊:European Journal of Medicinal Chemistry, 页码:1912-1918 , 文章类型: Article,,卷期:2010年45-5]
- Allylsulfides from garlic are chemopreventive agents. Entering cells they are expected to initially interact with glutathione. Accordingly, reaction mechanisms of the product, S-allylthio-glutathione, with model proteins...
- Synthesis and antiviral activity of new acrylamide derivatives containing 1,2,3-thiadiazole as inhibitors of hepatitis B virus replication
[作者:Dong, WL; Liu, ZX; Liu, XH; Li, ZM; Zhao, WG,期刊:European Journal of Medicinal Chemistry, 页码:1919-1926 , 文章类型: Article,,卷期:2010年45-5]
- A series of new acrylamide derivatives containing 1,2,3-thiadiazole were synthesized, characterized, and evaluated for their anti-hepatitis B virus (HBV) activities in vitro. The IC50 of compounds 9b (10.4 mu g/mL), 9c (...
- Thiosemicarbazones, semicarbazones, dithiocarbazates and hydrazide/hydrazones: Anti-Mycobacterium tuberculosis activity and cytotoxicity
[作者:Pavan, FR; Maia, PID; Leite, SRA; Deflon, VM; Batista, AA; Sato, DN; Franzblau, SG; Leite, CQF,期刊:European Journal of Medicinal Chemistry, 页码:1898-1905 , 文章类型: Article,,卷期:2010年45-5]
- The aim of this study was to identify a candidate drug for the development of anti-tuberculosis therapy from previously synthesized compounds based on the thiosemicarbazones, semicarbazones, dithio-carbazates and hydrazi...
- Synthesis, spectroscopic and biological studies on the new symmetric Schiff base derived from 2,6-diformyl-4-methylphenol with N-aminopyrimidine
[作者:Sonmez, M; Celebi, M; Berber, I,期刊:European Journal of Medicinal Chemistry, 页码:1935-1940 , 文章类型: Article,,卷期:2010年45-5]
- A phenol based novel Schiff base polydentate symmetric ligand was prepared. The complexes were prepared by reacting ligand and the metal chlorides of Cu (II), Ni(II), Co(II) and Fe(II) in methanol to get a series of mono...
- Synthesis and biological activity of n-butylphthalide derivatives
[作者:Wang, W; Cha, XX; Reiner, J; Gao, Y; Qiao, HL; Shen, JX; Chang, JB,期刊:European Journal of Medicinal Chemistry, 页码:1941-1946 , 文章类型: Article,,卷期:2010年45-5]
- A series of n-butylphthalide derivatives were designed and synthesized. The in vitro activities of these compounds were evaluated by a resting tension of isolated rat thoracic aorta ring assay. Compounds 4g and 41 were f...
- Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones
[作者:Effenberger, K; Breyer, S; Schobert, R,期刊:European Journal of Medicinal Chemistry, 页码:1947-1954 , 文章类型: Article,,卷期:2010年45-5]
- Doxorubicin N-acylhydrazones derived from saturated, unsaturated and terpene-terminated fatty acids were tested for anticancer activity in cells of human HL-60 leukaemia, 518A2 melanoma, MCF-7/Topo breast and KB-V1/Vbl c...
- Design, synthesis and biological evaluation of new ionone derivatives as potential neuroprotective agents in cerebral ischemia
[作者:Srivastava, AK; Dohare, P; Ray, M; Panda, G,期刊:European Journal of Medicinal Chemistry, 页码:1964-1971 , 文章类型: Article,,卷期:2010年45-5]
- A new series of ionone derived allylic alcohols have been evaluated for anti-ischemic activity. Out of them, 121 and 13b decreased infarct volume to 23.98 +/- 4.7 mm(3) and 93.98 /- 24.8 mm(3) as compared to ischemic gro...
- Synthesis of some new pyrimido[2 ',1 ':2,3]thiazolo[4,5-b]quinoxaline derivatives as anti-inflammatory and analgesic agents
[作者:Abu-Hashem, AA; Gouda, MA; Badria, FA,期刊:European Journal of Medicinal Chemistry, 页码:1976-1981 , 文章类型: Article,,卷期:2010年45-5]
- Treatment of 6-aminothiouracil (1) with 2,3-dichloroquinoxaline (2) in ethanol/TEA afforded 6-amino-2-(3-chloroquinoxalin-2-ylthio)pyrimidin-4(3H)-one (3), which was refluxed in DMF to give 2-aminopyrimidoi[2',1':2,3]thi...
- Phosphaisocoumarins as a new class of potent inhibitors for pancreatic cholesterol esterase
[作者:Li, BJ; Zhou, BH; Lu, HL; Ma, L; Peng, AY,期刊:European Journal of Medicinal Chemistry, 页码:1955-1963 , 文章类型: Article,,卷期:2010年45-5]
- Due to the importance of pancreatic cholesterol esterase (CEase) as a potential target in atherosclerosis and for the development of hypocholesterolemic agents, there are increasing interests in designing and synthesizin...
- Assessing the chemical diversity of an hsp90 database
[作者:Audisio, D; Messaoudi, S; Ijjaali, I; Dubus, E; Petitet, F; Peyrat, JF; Brion, JD; Alami, M,期刊:European Journal of Medicinal Chemistry, 页码:2000-2009 , 文章类型: Article,,卷期:2010年45-5]
- The 90-kDa heat shock protein (hsp90) has emerged as a new, promising target for cancer drug discovery. With the simultaneous disruption of a large range of oncogenic pathways, hsp90 inhibition results in either cytostas...
- Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone
[作者:Seo, WD; Ryu, YB; Curtis-Long, MJ; Lee, CW; Ryu, HW; Jang, KC; Park, KH,期刊:European Journal of Medicinal Chemistry, 页码:2010-2017 , 文章类型: Article,,卷期:2010年45-5]
- The 4'-(p-toluenesulfonylamino)-4-hydroxychalcone (TSAHC), which bears inhibitory chemotypes for both alpha-glucosidase and tyrosinase, was evaluated for tyrosinase activity and depigmenting ability relative to compounds...
- Catalytic nanomedicine: A new field in antitumor treatment using supported platinum nanoparticles. In vitro DNA degradation and in vivo tests with C6 animal model on Wistar rats
[作者:Lopez, T; Figueras, F; Manjarrez, J; Bustos, J; Alvarez, M; Silvestre-Albero, J; Rodriguez-Reinoso, F; Martinez-Ferre, A; Martinez, E,期刊:European Journal of Medicinal Chemistry, 页码:1982-1990 , 文章类型: Article,,卷期:2010年45-5]
- Novel nanostructured TiO2 and SiO2 based biocatalysts, with 3-4 wt. % of Pt have been developed. The obtained materials exhibit a high surface area together with a broad pore size distribution. The method of synthesis al...
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