- Synergistic Activity of Histone Deacetylase and Proteasome Inhibition Against Pancreatic and Hepatocellular Cancer Cell Lines
[作者:Spratlin, JL; Pitts, TM; Kulikowski, GN; Morelli, MP; Tentler, JJ; Serkova, NJ; Eckhardt, SG,期刊:Anticancer Research, 页码:1093-1103 , 文章类型: Article,,卷期:2011年31-4]
- Aim: To determine the phenotypic effects of belinostat (bel) and bortezomib (bor) against pancreatic cancer (PC) and hepatocellular cancer (HCC) cell lines. Materials and Methods: Antiproliferative effects were assessed ...
- Revitalization of Human Bone after Extracorporeal High Hydrostatic Pressure Treatment
[作者:Schauwecker, J; Von Eisenhart-Rothe, R; Burgkart, R; Tuebel, J; Schmitt, M; Mittelmeier, W; Diehl, P,期刊:Anticancer Research, 页码:1235-1239 , 文章类型: Article,,卷期:2011年31-4]
- Background: Bone defects due to malignant tumor often lead to repeated surgery or amputation. Thus, a major objective in orthopedic surgery is the extracorporeal devitalization of tumor-bearing bone segments following re...
- Enhancement of Dectin-2 Gene Expression by Lignin-Carbohydrate Complex from Lentinus edodes Mycelia Extract (LEM) in a Mouse Macrophage-like Cell Line
[作者:Kushida, T; Makino, T; Tomomura, M; Tomomura, A; Sakagami, H,期刊:Anticancer Research, 页码:1241-1248 , 文章类型: Article,,卷期:2011年31-4]
- Background: Lignin fractions of Lentinus edodes mycelia extract (LEM) have shown anti-HIV and immunopotentiating activity. However, the action point of lignin-carbohydrate complex has not been elucidated. In order to elu...
- Induction of MMP-13 Expression in Bone-metastasizing Cancer Cells by Type I Collagen through Integrin alpha 1 beta 1 and alpha 2 beta 1-p38 MAPK Signaling
[作者:Ibaragi, S; Shimo, T; Hassan, NMM; Isowa, S; Kurio, N; Mandai, H; Kodama, S; Sasaki, A,期刊:Anticancer Research, 页码:1307-1313 , 文章类型: Article,,卷期:2011年31-4]
- Background: Breast cancer cells frequently metastasize to the skeleton and produce and secrete proteinases, such as matrix metalloproteinase-13 (MMP-13), which promote destruction of the bone matrix. However, the mechani...
- Chitosan Derivatives Inhibit Cell Proliferation and Induce Apoptosis in Breast Cancer Cells
[作者:Jiang, M; Ouyang, HD; Ruan, P; Zhao, H; Pi, ZJ; Huang, SL; Yi, P; Crepin, M,期刊:Anticancer Research, 页码:1321-1328 , 文章类型: Article,,卷期:2011年31-4]
- Background/Aim: Both the sulfated and non-sulfated derivatives (e.g. carboxymethyl benzylamide dextrans) of heparan sulfate were reported to have anticancer activity. On this basis, we introduced sulfates and phenyls in ...
- Potential Tumor-tropic Effect of Genetically Engineered Stem Cells Expressing Suicide Enzymes to Selectively Target Invasive Cancer in Animal Models
[作者:Kim, SU; Jeung, EB; Kim, YB; Cho, MH; Choi, KC,期刊:Anticancer Research, 页码:1249-1258 , 文章类型: Review,,卷期:2011年31-4]
- Stem cells have recently received a great deal of attention for their clinical and therapeutic potential to treat human disease and disorders. For instance, neural stein cells expressing a suicide gene which can concert ...
- Two-dimensional Gel Electrophoresis Using Immobilized pH Gradient Strips and Flamingo (TM) Fluorescent Gel Stain Identified Non-nuclear Proteins Possibly Related to Malignant Tumour Progression
[作者:Kuramitsu, Y; Hayashi, E; Okada, F; Zhang, XL; Ueyama, Y; Nakamura, K,期刊:Anticancer Research, 页码:1259-1263 , 文章类型: Article,,卷期:2011年31-4]
- The understanding of tumour progression is one of the most important strategies to conquer tumour. QR-32 is a regressive murine fibrosarcoma cell line, and QRsP-11 is a progressive malignant tumour cell clone derived fro...
- Claudin-4: A Potential Therapeutic Target in Chemotherapy-resistant Ovarian Cancer
[作者:Yoshida, H; Sumi, T; Zhi, X; Yasui, T; Honda, KI; Ishiko, O,期刊:Anticancer Research, 页码:1271-1277 , 文章类型: Article,,卷期:2011年31-4]
- Background: Claudin-4, a component of the tight junction, plays an important role in tumorigenesis and metastasis of ovarian cancer, but its role in platinum resistance has not been elucidated. Materials and Methods: Cla...
- Adenoviral Therapy Is More Effective in Gemcitabine-resistant Pancreatic Cancer than in Gemcitabine-sensitive Cells
[作者:Yasui, T; Ohuchida, K; Zhao, M; Cui, L; Onimaru, M; Egami, T; Fujita, H; Ohtsuka, T; Mizumoto, K; Matsumoto, K; Tanaka, M,期刊:Anticancer Research, 页码:1279-1287 , 文章类型: Article,,卷期:2011年31-4]
- Background: Although genicitabine is the standard treatment for pancreatic cancer, this particular type of cancer develops rapidly and has intrinsic chemoresistance. Chemoresistance plays a critical role in tumor progres...
- Aberrant Methylation of the Vimentin Gene in Hepatocellular Carcinoma
[作者:Kitamura, Y; Shirahata, A; Sakuraba, K; Goto, T; Mizukami, H; Saito, M; Ishibashi, K; Kigawa, G; Nemoto, H; Sanada, Y; Hibi, K,期刊:Anticancer Research, 页码:1289-1291 , 文章类型: Article,,卷期:2011年31-4]
- Background: Recently, it was shown that the Vimentin gene, usually activated in mesenchymal cells, was highly methylated in colorectal carcinoma. Materials and Methods: The methylation status of the Vimentin gene was exa...
- Methylation of OSMR Gene Is Frequently Observed in Non-invasive Colorectal Cancer
[作者:Hibi, K; Goto, T; Sakuraba, K; Shirahata, A; Saito, M; Ishibashi, K; Kigawa, G; Nemoto, H; Sanada, Y,期刊:Anticancer Research, 页码:1293-1295 , 文章类型: Article,,卷期:2011年31-4]
- Background: Recently, it has been reported that oncostatin M receptor-beta (OSMR) is frequently methylated in primary colon cancer tissues, but not in normal tissues. We examined the methylation status of the OSMR gene i...
- Involvement of Cancer Biomarker C7orf24 in the Growth of Human Osteosarcoma
[作者:Uejima, D; Nishijo, K; Kajita, Y; Ishibe, T; Aoyama, T; Kageyama, S; Iwaki, H; Nakamura, T; Iida, H; Yoshiki, T; Toguchida, J,期刊:Anticancer Research, 页码:1297-1305 , 文章类型: Article,,卷期:2011年31-4]
- Background: Up-regulation of the expression of the gene C7orf24, encoding gamma-glutamyl cyclotransferase, is a common event in cancers derived from various tissues, but its involvement in osteosarcomas (OS) has not yet ...
- Targeting Notch to Eradicate Pancreatic Cancer Stem Cells for Cancer Therapy
[作者:Wang, ZW; Ahmad, A; Li, YW; Azmi, AS; Miele, L; Sarkar, FH,期刊:Anticancer Research, 页码:1105-1113 , 文章类型: Review,,卷期:2011年31-4]
- Pancreatic cancer is the most aggressive malignant disease once it is diagnosed and it remains the fourth leading cause of cancer-related death in the U.S.A. Recent data indicates that the Notch signaling pathway plays a...
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