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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   Three Down and One To Go: Modeling Medulloblastoma Subgroups [作者：Eberhart, CG,期刊：Cancer Cell, 页码：137-138 , 文章类型： Editorial Material，,卷期：2012年21-2] In this issue of Cancer Cell, Pei et al. and Kawauchi et al. describe murine models of an aggressive medulloblastoma subtype driven by Myc. These tumors have a cellular origin, microscopic appearance, and molecular profi... VEGF-D(ilated) Lymphatics as Gateways to Metastasis [作者：Rak, J,期刊：Cancer Cell, 页码：139-140 , 文章类型： Editorial Material，,卷期：2012年21-2] VEGF-C and VEGF-D have been implicated in lymphatic metastasis, mainly as inducers of new intra/peritumoral capillary lymphatics. In this issue of Cancer Cell, Karnezis and colleagues challenge this notion and demonstrat... aSIRTing Control over Cancer Stem Cells [作者：Ito, T; Zimdahl, B; Reya, T,期刊：Cancer Cell, 页码：140-142 , 文章类型： Editorial Material，,卷期：2012年21-2] Cancer stem cells lie at the root of chronic myelogenous leukemia (CML) and mediate its continued growth. Their resistance to current therapies results in an inability to eradicate the disease. In this issue of Cancer Ce... Glycine Decarboxylase Cleaves a "Malignant" Metabolic Path to Promote Tumor Initiation [作者：Dominy, JE; Vazquez, F; Puigserver, P,期刊：Cancer Cell, 页码：143-145 , 文章类型： Editorial Material，,卷期：2012年21-2] Tumor-initiating cells (TICs) are thought to be critical for promoting tumorigenesis. In a recent Cell article, Zhang and colleagues found that non-small cell lung cancer TICs overexpress the metabolic enzyme glycine dec... PI3King on MYCN to Improve Neuroblastoma Therapeutics [作者：Hogarty, MD; Maris, JM,期刊：Cancer Cell, 页码：145-147 , 文章类型： Editorial Material，,卷期：2012年21-2] MYCN is an oncogenic driver of childhood neuroblastoma, a frequently lethal pediatric tumor. In a recent paper in Science Translational Medicine, Chanthery and colleagues demonstrate that PI3K inhibition leads to the dua... The RAF Inhibitor Paradox Revisited [作者：Cox, AD; Der, CJ,期刊：Cancer Cell, 页码：147-149 , 文章类型： Editorial Material，,卷期：2012年21-2] The success of the RAF protein kinase inhibitor vemurafenib for the treatment of BRAF mutant metastatic melanoma has produced another poster child for the promise of personalized medicine. However, the results of a recen... Conflicting Roles of Molecules in Hepatocarcinogenesis: Paradigm or Paradox [作者：Feng, GS,期刊：Cancer Cell, 页码：150-154 , 文章类型： Review，,卷期：2012年21-2] In delineating the molecular pathogenesis of hepatocellular carcinoma (HCC), recent experiments in mouse tumor models have revealed unexpected tumor-suppressing effects in genes previously identified as pro-oncogenic. Th... An Animal Model of MYC-Driven Medulloblastoma [作者：Pei, YX; Moore, CE; Wang, J; Tewari, AK; Eroshkin, A; Cho, YJ; Witt, H; Korshunov, A; Read, TA; Sun, JL; Schmitt, EM; Miller, CR; Buckley, AF; McLendon, RE; Westbrook, TF; Northcott, PA; Taylor, MD; Pfister, SM; Febbo, PG; Wechsler-Reya, RJ,期刊：Cancer Cell, 页码：155-167 , 文章类型： Article，,卷期：2012年21-2] Medulloblastoma (MB) is the most common malignant brain tumor in children. Patients whose tumors exhibit overexpression or amplification of the MYC oncogene (c-MYC) usually have an extremely poor prognosis, but there are... A Mouse Model of the Most Aggressive Subgroup of Human Medulloblastoma [作者：Kawauchi, D; Robinson, G; Uziel, T; Gibson, P; Rehg, J; Gao, CL; Finkelstein, D; Qu, CX; Pounds, S; Ellison, DW; Gilbertson, RJ; Roussel, MF,期刊：Cancer Cell, 页码：168-180 , 文章类型： Article，,卷期：2012年21-2] Medulloblastomas that display a large cell/anaplastic morphology and overexpress the cellular c-MYC gene are highly aggressive and carry a very poor prognosis. This so-called MYC-subgroup differs in its histopathology, g... VEGF-D Promotes Tumor Metastasis by Regulating Prostaglandins Produced by the Collecting Lymphatic Endothelium [作者：Karnezis, T; Shayan, R; Caesar, C; Roufail, S; Harris, NC; Ardipradja, K; Zhang, YF; Williams, SP; Farnsworth, RH; Chai, MG; Rupasinghe, TWT; Tull, DL; Baldwin, ME; Sloan, EK; Fox, SB; Achen, MG; Stacker, SA,期刊：Cancer Cell, 页码：181-195 , 文章类型： Article，,卷期：2012年21-2] Lymphatic metastasis is facilitated by lymphangiogenic growth factors VEGF-C and VEGF-D that are secreted by some primary tumors. We identified regulation of PGDH, the key enzyme in prostaglandin catabolism, in endotheli... Aurora Kinase-A Inactivates DNA Damage-Induced Apoptosis and Spindle Assembly Checkpoint Response Functions of p73 [作者：Katayama, H; Wang, J; Treekitkarnmongkol, W; Kawai, H; Sasai, K; Zhang, H; Wang, H; Adams, HP; Jiang, SL; Chakraborty, SN; Suzuki, F; Arlinghaus, RB; Liu, JS; Mobley, JA; Grizzle, WE; Wang, HM; Sen, S,期刊：Cancer Cell, 页码：196-211 , 文章类型： Article，,卷期：2012年21-2] Elevated Aurora kinase-A expression is correlated with abrogation of DNA damage-induced apoptotic response and mitotic spindle assembly checkpoint (SAC) override in human tumor cells. We report that Aurora-A phosphorylat... TEM8/ANTXR1 Blockade Inhibits Pathological Angiogenesis and Potentiates Tumoricidal Responses against Multiple Cancer Types [作者：Chaudhary, A; Hilton, MB; Seaman, S; Haines, DC; Stevenson, S; Lemotte, PK; Tschantz, WR; Zhang, XYM; Saha, S; Fleming, T; St Croix, B,期刊：Cancer Cell, 页码：212-226 , 文章类型： Article，,卷期：2012年21-2] Current antiangiogenic agents used to treat cancer only partially inhibit neovascularization and cause normal tissue toxicities, fueling the need to identify therapeutic agents that are more selective for pathological an... Inhibition of PI3K/mTOR Leads to Adaptive Resistance in Matrix-Attached Cancer Cells [作者：Muranen, T; Selfors, LM; Worster, DT; Iwanicki, MP; Song, LL; Morales, FC; Gao, SZ; Mills, GB; Brugge, JS,期刊：Cancer Cell, 页码：227-239 , 文章类型： Article，,卷期：2012年21-2] The PI3K/mTOR-pathway is the most commonly dysregulated pathway in epithelial cancers and represents an important target for cancer therapeutics. Here, we show that dual inhibition of PI3K/mTOR in ovarian cancer-spheroid... Tumorigenic Cells Are Common in Mouse MPNSTs but Their Frequency Depends upon Tumor Genotype and Assay Conditions [作者：Buchstaller, J; McKeever, PE; Morrison, SJ,期刊：Cancer Cell, 页码：240-252 , 文章类型： Article，,卷期：2012年21-2] Tumor-initiating cells have been suggested to be rare in many cancers. We tested this in mouse malignant peripheral nerve sheath tumors (MPNSTs) and found that 18% of primary and 49% of passaged MPNST cells from Nfl(+/-)... Adult Murine Prostate Basal and Luminal Cells Are Self-Sustained Lineages that Can Both Serve as Targets for Prostate Cancer Initiation [作者：Choi, N; Zhang, BY; Zhang, L; Ittmann, M; Xin, L,期刊：Cancer Cell, 页码：253-265 , 文章类型： Article，,卷期：2012年21-2] The prostate epithelial lineage hierarchy and the cellular origin for prostate cancer remain inadequately defined. Using a lineage-tracing approach, we show that adult rodent prostate basal and luminal cells are independ... Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib [作者：Li, L; Wang, LS; Li, L; Wang, ZQ; Ho, YW; McDonald, T; Holyoake, TL; Chen, WY; Bhatia, R,期刊：Cancer Cell, 页码：266-281 , 文章类型： Article，,卷期：2012年21-2] BCR-ABL tyrosine kinase inhibitors (TKI) fail to eliminate quiescent leukemia stem cells (LSC) in chronic myelogenous leukemia (CML). Thus, strategies targeting LSC are required to achieve cure. We show that the NAD(+)-d...