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A new class of NO-donor pro-drugs triggered by gamma-glutamyl transpeptidase with potential for reno-selective vasodilatation

  作者 ZHANG QINGZHI; KULCZYNSKA AGNIESZKA; WEBB DAVID J; MEGSON IAN L; BOTTING NIGEL P  
  选自 期刊  Chemical Communications;  卷期  2013年49-14;  页码  1389-1391  
  关联知识点  
 

[摘要]This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of gamma-glutamyl transpeptidase (gamma-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

 
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